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  • Anticoagulants - 16 05 13 DEF - 02

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    1) Historical anticoagulants like warfarin and heparin indirectly inhibit coagulation factors IIa and Xa through antithrombin. 2) Newer anticoagulants directly inhibit individual coagulation factors, including direct thrombin inhibitors (DTIs) that target IIa and drugs that target Xa. 3) Physiologically, coagulation is regulated by antithrombin and tissue factor pathway inhibitor, which inhibit thrombin and factor Xa activity through heparan sulfate and dermatan sulfate on endothelial cells.

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    1) Historical anticoagulants like warfarin and heparin indirectly inhibit coagulation factors IIa and Xa through antithrombin. 2) Newer anticoagulants directly inhibit individual coagulation factors, including direct thrombin inhibitors (DTIs) that target IIa and drugs that target Xa. 3) Physiologically, coagulation is regulated by antithrombin and tissue factor pathway inhibitor, which inhibit thrombin and factor Xa activity through heparan sulfate and dermatan sulfate on endothelial cells.

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    4 views2 pages

    Anticoagulants - 16 05 13 DEF - 02

    Uploaded by

    elaaannabi1
    1) Historical anticoagulants like warfarin and heparin indirectly inhibit coagulation factors IIa and Xa through antithrombin. 2) Newer anticoagulants directly inhibit individual coagulation factors, including direct thrombin inhibitors (DTIs) that target IIa and drugs that target Xa. 3) Physiologically, coagulation is regulated by antithrombin and tissue factor pathway inhibitor, which inhibit thrombin and factor Xa activity through heparan sulfate and dermatan sulfate on endothelial cells.

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    of 2

    ANTICOAGUL A

    NTS

    IIa AT HC II

    IIa Fibrin
    IIa

    Fibrinogen
    Historical Multi target Anticoagulants

    IIa

    AT
    VKA Specific anti-IIa and anti-Xa drugs
    • warfarin II
    • nicoumalone,
    PS
    acenocoumarol, Anti-IIa
    V AP
    phenprocoumon C AT
    and fluindione • hirudin and analogues
    Va Xa Activated
    Platelet (desirudin) Direct
    • synthetic DTIs (argatroban, effect
    Heparins VWF bivalirudin, dabigatran)
    X
    • UFH Indirect
    AT
    • LMWHs effect XI Anti-Xa
    IXa VIIIa APC PS
    VIII • danaparoid sodium Indirect
    • fondaparinux effect
    XIa
    IX
    T
    A

    • rivaroxaban, apixaban, Direct


    edoxaban, betrixaban effect
    Xa TFPI
    VIIa VII

    4614 © 2011 DIAGNOSTICA STAGO - All rights reserved - 04/2013 - Ref. 27853
    TF

    Physiological anti-IIa and anti-Xa

    AT AT
    AT AT

    AT: Antithrombin
    HC II HC II

    anti-IIa HC II: Heparin Cofactor II


    Heparan TFPI TFPI
    anti-Xa
    TFPI: Tissue Factor Pathway Inhibitor
    sulphate
    UFH: Unfractionated Heparin
    Dermatan Heparan Diagnostica Stago S.A.S.
    sulphate sulphate LMWH: Low Molecular Weight Heparin RCS Nanterre B305 151 409
    9, rue des Frères Chausson
    92600 Asnières sur Seine (France)
    Ph.: +33 (0)1 46 88 20 20
    Fax: +33 (0)1 47 91 08 91
    webmaster@stago.com
    At the Heart of Haemostasis www.stago.com
    ANTICOAGULANTS R EF. 27853
    27853 R EF. ANTICOAGULANTS

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