BeautiFerm

Healerine
NATURE‘S ANCIENT ELIXIR TO
BOOST SKIN REGENERATION

March 2023

1
 BeautiFerm
Active Ingredients

Scientifically proven to activate

mechanism that help to restore the skin’s
youthful appearance

Natural concepts for healthy-looking skin

Powerful and safe ingredients from a

sustainable fermentation process

2 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

 „Think: Kombucha, but for your skin“
Fermented Beauty continues to be a trend in skin care
Fermented Skin Care: Here’s Slugging
What You Need to Know is passé,
What do kombucha and hyaluronic acid have in fermented
common? Fermentation – a process that brings
powerful perks. skincare is the
Mar 7, 2023 next ‘it’ thing in
2023
Why Fermented Skincare Is Your
Move over kimchi and
Next Beauty Obsession kombucha, fermentation
has successfully made its
Think: Kombucha, but for your skin.
way to beauty products
June 08, 2022
27 December 2022

INDIA

3 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

Fermented Actives

Broad spectrum of Skin microbiome

THE BASICS Enhanced bioavailability
bioactives benefits

Suitable for all skin Postbiotic & Natural & clean

types paraprobiotic concepts ingredients

4 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

Key Drivers for Fermented Beauty
Sustainable biotech
empowering clean beauty
▪ Natural ingredient sourcing becoming
more challenging
▪ Fermentation is a biotech using nature to
obtain potent and safe ingredients in a
sustainable way
5 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
Total well-being
▪ Proactive & preventive skin health is
increasingly important for consumer
▪ Microbiome related claims based on
fermented products resonate with
consumers adopting a holistic approach
to health & wellbeing
Youth through science
▪ The search for youth continues, even as
consumers recognize that skin aging is
unavoidable
▪ Skintellectual consumers are more
actively seeking data demonstrating
efficacy
Key Driver
Sustainable biotech empowering clean beauty

Consumers increasingly
prefer natural
ingredients, as these are
perceived as safer
Early Adoption of
Fermented Beauty
26% of US
consumers perceive lab-
grown, nature-identical
ingredients as effective2

Clean Beauty
42% of US skincare consumers agree that natural/
clean ingredients are among their top 5 claims or
attributes they consider when shopping for skincare1

1. Mintel “Facial Skincare – US, 2022”

2. Kantar Profiles/Mintel, August 2021 survey of US 357 internet users aged 25-34 who used BPC products in the past 12 months

6 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

Key Driver
Total well-being

Skinmunity
Consumers are focusing
more on proactive and 67%
preventive skin health of Saudi
and are increasingly consumers take a
paying attention to the preventative
role of the microbiome approach in beauty
and skincare1

Interest in Skin Microbiome

40% of Spanish men who use facial skincare/haircare

products would be interested in using microbiome-friendly
products2

1. Kantar Profiles/Mintel, August 2022 survey of Saudi Arabia, 1000 internet users aged 18+, citred in “Middle East: elevate wellness conversation in Skin” March 2022
2. Lightspeed/Mintel survey of 976 consumers in Spain aged 16+ who have used skin/hair BPC in last 6 months, cited in “The new shapes of health and wellness in BPC” April 2020

7 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

Key Driver
Youth through science

Efficacy
Skintellectual
consumers are seeking 53%
solutions that have of adults in Canada who
support based in research BPC ingredients
science do so to better understand
product effectiveness1

47%
of Chinese beauty consumers associate
effectiveness with ingredients from microorganisms
(e.g., bifida ferments)2

1 Base: Canada: 1,545 internet users aged 18+ who research ingredients used in products. Source: Kantar Profiles/Mintel, August 2021
2 Base: China: 2,943 female internet users aged 18-49 who pay attention to beauty and personal care products' ingredients. Source: KuRunData/Mintel, January 2021 (China);

8 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

 A new family of fermented actives
BeautiFerm Lift BeautiFerm Resurf BeautiFerm Healerine

Nature‘s
Resurfacing of
Visible skin ancient elixir
skin to restore a
firming to boost skin
youthful glow
regeneration

9 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

 BeautiFerm Healerine
Nature‘s ancient elixir to boost skin regeneration

Balances the natural slow-down in skin renewal due to

aging with a boost in skin regeneration

Accelerates skin barrier recovery after disruption

A green solution for skin breakouts, imperfections and

residual marks

Natural ingredient obtained from Reishi mushroom

(Ganoderma lucidum) fermentation, elevating a long
tradition of use in Asia with advanced biotechnology for
skin care benefits

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10
BeautiFerm Healerine
Nature's ancient elixir fermented from the reishi mushroom

RICH BIOACTIVE PROFILE

REISHI
FIP
THE MUSHROOM Diverse range of (Fungal Immuno-
Beta-glucans
OF IMMORTALITY triterpenoids* modulatory Proteins)

Precursors of cell Antioxidant, wound Support an correct

membrane molecules, healing and immune system response
improving and supporting moisturization activity
skin barrrier function

As consumers become more aware of the quality Used in cosmetics for

and origin of ingredients, Ganoderma lucidum's • Antiaging
rich bioactive profile • Anti-inflammatory,
Ganoderma lucidum (“Reishi”) has been
valued as a traditional source of natural • can help brands develop products that address • Hydration & immune system
bioactive compounds for centuries and lately, complex needs and booster, and lately for
a trending adaptogen in skincare • Wound healing and skin
• creates opportunities across all BPC categories. regeneration
* especially ganoderic acids
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11 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
 Claim substantiation

in vivo in vitro
Wound healing assay
(Laser induced skin lesions)
Skin barrier function
Re-epithelialization
recovery
Clinical 3D Image Analysis
photography with FOITS
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12 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
BeautiFerm Healerine
Supports skin regeneration and recovery in vivo
results
Placebo 1% BeautiFerm Healerine

Laser ablative -21%

Wound
lesions images t=0h volume

Wound induced by
laser.
10 µm depth and 5
mm width. N=1.
- 21%
Wound
- 40%
Wound
Area: back. circumference area

1% BeautiFerm
Healerine. Controlled
by placebo. t=24h

Picture and image - 62%

Wound
-130%
Wound
analysis
mean depth max depth
at t=0 and t = 24
hours.
Crusting areas Marked degree of Weak erythema. No crusting.
erythema
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13 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
BeautiFerm Healerine
Supports skin regeneration and recovery in vivo
results

3 Dimensional +27%
analysis of the Regenerated tissue

skin structure
Z (mm) Placebo Z (mm) 1% BeautiFerm Healerine
0.084 0.055
Wound induced by
laser. 10 µm depth
and 5 mm width.
N=1. Area: back.
1% BeautiFerm
Healerine.
-0.083 -0.158
Controlled by
placebo.
3D Image Analysis
with FOITS
(Fast Optical In vivo Skin section at t = 0 h Skin section at t = 0 h
Topometry of human Skin section at t = 24 h Skin section at t = 24 h
Skin) at t=0 and t = -0.250 -0.372
-0.000 3.371 6.742 -0.000 3.138 6.276
24 hours.
Length (mm) Length (mm)

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14 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
BeautiFerm Healerine
Accelerates skin barrier function recovery (after insult) in vivo
results

D1 D2 D5 D8 D10 D12 D15 D16-D18 D19 D22 D23-D25 D26

SLS application  Many surfactants including SLS

disrupt the skin barrier function
BeautiFerm Healerine Twice a day
SLS Patch test resulting in erosion, increased
Biometric measurements             TEWL and increased blood flow
reaction
clinically visible as erythema(2)
Skin Regeneration
(Time to recover skin barrier function= D0)
SLS Patch test 25
Erythema recovery time (days)

reaction.
23
Exposure to 2%
SLS for 24 hours. 22 -3 -6
Days Days
Area: back, N=5 BeautiFerm Healerine
1 % BeautiFerm 20 19 decreases the skin color
Healerine applied recovery time and
twice a day.
Controlled by
17
Placebo
accelerates the skin
placebo. regeneration process
Healerine
15
Chromameter and
Mean Best responder
clinical evaluation

Pieter G. M. Van der Valk, M.D., Johan P. Nater, M.D., and Eric Bleumink, Ph.D. Skin irritancy of surfactants as assessed by water vapor

(2)
loss measurements. THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, 82:291- 293, 1984.

15 Evonik | March 2023 | Market Presentation BeautiFerm Healerine

BeautiFerm Healerine
Speeds up epidermal re-epithelialization in vitro
results

+ 45%
Quicker Re-epithelialization
Re-
epithelialization Relative wound area Relative wound healing
160 80

Scratch (2 mm)

Relative wound healing to control (%)

in human
Relative wound area to control (%)

keratinocytes 60 -
monolayer. 100 -
44.6%
***
***
0.1% BeautiFerm
Healerine in the * 40 -
*
culture media and *** ***
control vehicle. 60 -
Positive control: 0.5 20 -
ppm EGF. t=18 hrs.
Picture and image
analysis. Wound 0 0
area after scratch Control Positive 0.001% 0.01% 0.1% Control Positive 0.001% 0.01% 0.1%
and t=18 hours. control control
BeautiFerm Healerine BeautiFerm Healerine

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16 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
BeautiFerm Healerine
Properties and Applications

PROPERTIES APPLICATIONS

Water (Aqua); Ganoderma

Lucidum Extract; Glycerin;
Propanediol;
INCI Dermocosmetics
Xanthan gum; 1,2-
Hexanediol, Caprylyl Glycol
(China IECIC listed)

Aqueous whitish
suspension
Product Form Skin protection-focused products
Dispersible in water and in
O/W, W/O emulsions

Recommended
Use Level
1% Natural cosmetics

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17 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
Formulating with BeautiFerm Healerine

FORMULATION HINTS
Recommended usage concentration: 0.5-1% (1%
clinically tested)
Solubility: BeautiFerm Healerine is water soluble
Recommended pH of the formulation: 4 – 8
pH of the raw material: 4 - 8
Processability: BeautiFerm Healerine is cold processable
Preparation of emulsions: BeautiFerm Healerine is added
during the cooling process at temperatures below 45°C
Stirring: Moderate to high agitation is compatible.
Conventional impeller such as propeller or turbines are
recommended

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18 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
BeautiFerm Healerine in a nutshell
Nature‘s ancient elixir to boost skin regeneration

Accelerates skin barrier

Natural, green, eco-
recovery
friendly cosmetic
after disruption
ingredient

IECIC
Obtained from
listed
Reishi Natural boost for
mushroom BeautiFerm
epidermal
fermentation Healerine regeneration
• Speeds up re-
epithelialization
The "mushroom of immortality“ in • More
Traditional Chinese Medicine A green solution for skin breakouts, regenerated
imperfections and residual marks tissue

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19 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
Natural Repair Lip Balm

Phase Ingredients % w/w PREPARATION

A Sweet Almond Oil (Prunus Amygdalus Dulcis Oil) 35.30 1. Heat phase A at 75 – 80 ºC.

Apricot Kernel Oil (Prunus Armeniaca (Apricot) 2. Cool down add the ingredients of phase B below 40ºC. Stir well until
8.00 homogeneous.
Kernel Oil)
Avocado Oil (Persea gratissima (Avocado) oil) 5.00 3. Fill into final packaging.
Grape Pepita Oil (Vitis viniefera seed oil) 10.00
Cera Alba 13.00
Shea Butter (Butyrospermum parkii butter) 15.00 Specification
Appearance: waxy emulsion
TEGOSOFT CR MB (Cetyl Ricinoleate) 2.00
Stability test: Yes
Lipocire A SG (C10-18 Triglycerides) 2.50
TEGOSOFT CT MB (Caprylic/Capric Triglyceride) 2.50
Lecithin 2.00
B Honey 1.50
Dermofeel Toco 70 Non GMO (Tocopherol, Helianthus Annus
0.20
(Sunflower) Seed Oil)
BeautiFerm Healerine 2.00
BeautiFerm Lift 1.00

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20 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
Shield Barrier Spray Mist

Phase Product name, INCI w/w % PREPARATION

1. Mix ingredients of phase A.
A Deionized Water 92.3
2. Add one by one the ingredients of phase B under stirring.
Glycerin 2.0 3. Adjust pH if is necessary.
Dermofeel PA-3 (Sodium Phytate; Aqua;
B 0.2
Alcohol)
Specification
Dermosoft Pentiol ECO (Pentylene Glycol) 2.0 Appearance: refreshing watery mist
pH-value: 5.50 – 6.50
BeautiFerm Healerine 2.0 Stability test: Yes
Verstatil SL non GMO (Aqua; Sodium
1.5
Levulinate; Potassium Sorbate)

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21 Evonik | March 2023 | Market Presentation BeautiFerm Healerine
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