DR-7000D Semi-automatic Chemistry Analyzer

Chemistry analyzer

service manual

Technical service department

 Semi-automatic Chemistry Analyzer

Content

Part 1 : Product introduction

Part 2 : The Basic Principle and Functional Feature

Part 3 : The photo of the instrument

Part 4 : Technique solution

Part 5 : Instrument Maintenance

Part 6 : The method of using “manufacturer setup” of semi-chemistry

analyzer

Appendix B Regular Chemistry Reagent List

Appendix C Communication Interface with Computer

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 Semi-automatic Chemistry Analyzer

Part 1 product introduction

Chemistry analyzer

1.1 About the analyzer

This Semi-automatic Chemistry Analyzer was designed in response to the needs of clinical tests. It is a
newly intelligentized filter chemistry analyzer.

The built-in dot matrix LCD display provided with apheliotropic board ensures the clear show of all test
results, functional status and operational instruction. The English indication system guides users’ operation,
and improves man-machine communication.

1.2 Specification:
A) Lamp-house: 12V/20V W lamp
B) Wavelength range: DR-7000E grating 300~800mm available
There are eight wavelengths in the DR-7000D filter:
340nm、405nm、450nm、492nm、505nm、546nm、578nm、630nm
C）Absorbency range: -0.3～3.0Abs
D）Wavelength accuracy: grating wavelength accuracy±1nm
Filter wavelength accuracy±1nm
E）External output: RS-232 serial port. Parallel interface for printer
F）Memory: QC data, 200 item parameters, 3000 testing results
G）Methodology: end point, kinetic, 2-point kinetic, absorbance,

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multipoint
H）Measurement time: 0～999 programmable
Delay time: 0～999 programmable
I） Flowcell: quartz flowcell, measuring volume is 32ul, light diameter is 1cm.
J）Temperature control: Peltier elements,25 ,30 ,37 and room temperature, accuracy ±0.1 。
K）Sampling system: the instrument adopt step motor control, sampling volume from 100ul to 9999ul
programmable

1.3 Biohazard mark

Biohazard Mark.
There are two biohazard marks on the equipment , one is on the back-board, another is on the top of the
pump pipette. As shown in Figure 1-1

Biohazard mark

Figure 1-1 Biohazard Mark.

There might be a potential infectivity for the sample & waste reagent, please make
sure to take protection action during the testing and cleaning process and instrument
maintenance.
Samples and waste reagent should be disposed in a suitable package conforming to the local
regulation for laboratory.

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 Semi-automatic Chemistry Analyzer

Part 2 The Basic Principle and Functional Feature

2.1 Basic principle

The principle of the instrument is based on the phenomenon of different wave band absorbance from
substance, which is in line with Lambert-Bill Law.

T=I/I。
A=log(I。/I)

T ____ Transparency
I ____ Transmitted light intensity
I。___ Incident light intensity
A ____ Absorbance

2.1.1 Optical system

The prismatic part of this Semi-automatic Chemistry analyzer adopts the filter in unique research and
manufacture techniques. It is featured by moist-resistant , heat-resistant, longevity of service ,little central
wavelength excursion, high optical signal-noise ratio etc. The principle diagram is shown as Figure 2-1.

Amplifier

Lamp-house Prismatic Flowcell Detector

System

Figure 2-1 Principle diagram of optical system

2.1.2 Electronic system

Flowcell Detector Amplifier

A/D
Monochromator

Driver control Computer system Temperature control

VG
Lamp-house VI Display/Keyboard Printer
Vn

Figure 2-2 Electronic principle diagram

The principle diagram of the electronic system is shown above in Figure 2-2. When passing through the
monochromator the ray of the lamp-house will be changed into monochromic light. The result will be then
received by the photoelectric detector when it passes through the flow colorimetric cuvette, and further
transformed into electric signal. The signal will be amplified and filtered, and then transmitted into A/D
transformer. When the information is transformed into numbers, it will be sent into data collection system
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of the computer for kinds of calculation and transaction. Users can either read the final result on the
display or alternatively get it printed out.

2.2 Functions
1.Measurement methods：
a)End-point b) Two-point kinetic
c)Kinetic d) Absorbance
e)Multipoint
2. Internal and external printer is available for uses’ options.
3. Sampling volume, test method is programmable
4. Users can determine whether to execute real time print out of the test results.
5. If any operational mistakes or other false results are found during the process of measurement, users can
choose the repeat key to retest, the original serial number of the test remains.
6.Rinsing program is available between two sample tests to avoid cross contamination.
7. Up to 31 days quality control tracking, and the printing results provided.
8. Integrated test report printing is available
9. Reaction curve display:
Reaction curve for sample and standard liquid will be displayed on the screen during the testing, as shown
in Figure 2-3.

ABS LIMIT
Absorbance Absorbance

ABS LIMIT
0 0
t1 time t1 time

Figure 2-3 Activity reaction curve

Note: 1. Press” +/-“ to check the reaction curve after testing the standard liquid or sample.
2. Press “Exit” to test next sample.

Part 3 the photo of the instrument

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 Semi-automatic Chemistry Analyzer

The photo of internal structure of chemistry analyzer

Name of part:

No Chinese name English name

打印机 Printer
吸样开关 Samping switch
液晶屏 LCD
键盘 keyboard

The internal structure of chemistry analyzer

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 Semi-automatic Chemistry Analyzer

Name of part:

No Chinese name English name

蠕动泵 Squirm pump
滤光盒 Filter box
滤光盘电机 Filter Plate motor
比色杯 Clorimetric cuvette
乌灯 Lamp
主板 Main board
电源 Power supply

The internal structrue of chemistry analyzer

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 Semi-automatic Chemistry Analyzer

Name of part:

No Chinese name English name

滤光盘电机 Filter Plate motor
滤光盘 Filter Plate
滤光片 Filter

The internal structure of chemistry analyzer

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 Semi-automatic Chemistry Analyzer

Name of part:

No Chinese name English name

吸样开关 Sampling switch
打印机转接板 Print connecting board
液晶屏转接板 LCD connecting board

The internal structure of chemistry analyzer –DR7000E

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 Semi-automatic Chemistry Analyzer

Name of part:

No Chinese name English name

比色杯 Colorimetric cuvette
单色仪 Monochromator
乌灯 Lamp
蠕动泵 Squirm pump
主板 Main board
电源 Power supply

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 Semi-automatic Chemistry Analyzer

Name of part:

No Chinese name English name

硅光电池/光电传感器 Photoelectricity sensor
帕尔贴 Peltier
温度传感器 Temperature sensor

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 Semi-automatic Chemistry Analyzer

The internal strutrue of monochromator

Name of part:

No Chinese name English name

光栅 grating
后透镜 Benind lens
霍尔元件 Hall
斩光轮 Wheel
反射镜 reflector
前透镜 Fore lens

Please note: even though there is fungus or dirty on the grating and reflector, also can’t wipe it ,
if wiping it so that run result is wrong.

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The main board of chemistry analyzer

Is peltier and it is calefactive

is temprerature sensor
is 3977 chip
is 4410 chip , its voltage is 6.3-6.8V it is control print, if this voltage is wrong then analyzer can’t
problem
is 4410 chip , its voltage is 5v, it is control temperature, if this voltage is wrong it means this chip is
broken, then intrument control temperature is wrong.
is 4410 chip and its voltage is 5v ,too.

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 Semi-automatic Chemistry Analyzer

Part 4 Technique solution

DR-7000 trouble shooting list

Fault Reason Trouble shooting

1.Print paper install is wrong 1.Reinstall print paper according
2.The connect wire between the to correct direction
print head and the print board is 2.Reinstall connect wire or
loose replace printer
Paper is
3.+6.3V output is abnormal or no 3.If the power supply output less
running but
output than +6.3V ,
not print
4.The connect wire between the please replace the 4410 chip
main board and the print board is 4.Reinstall the connect wire
loose between the main board and the
print board
1.There is air bubble in the 1.Using alcohol to clean the
colorimetric pool or the colorimetric colorimetric pool or replace it
is dirty 2.Check inner parameter of
2.The wavelength of monochromatic monochromatic light source
light source is wrong 3.Reinstall the connect wire
3.The connect wire between the 4.Replace the photoelectric
Display
silica photoelectric battery and the battery
trouble 001 or
main board is loose 5.Replace input pipette or pump
low A/D value
4.Silica photoelectric battery is pipette
broken 6.Re-calibration chopping
5.Input pipette or Pump pipette is wheeler step
broken
6..Chopping wheel motor step is
wrong
1.The connect wire between the 1.Reinstall the connect wire
monochromatic light source and the 2.Re-joint or replace the 3977
main board is loose chip
2.The motor drive chip 3977 is false 3.Reinstall connect wire or Hall
jointed or broken switch
Display
3.Connection between the Hall 4.Re-input parameter of
grating motor
switch and the main board is loose monochromatic light source
trouble
or broken 5.Replace the power supply
4.Parameter of monochromatic light
source is incorrect
5.Check +13.6V and +5V of the
power supply
1.Motor drive chip 2916 is false 1.Replace 2916 chip or re-joint it
“fault for jointed or broken 2.Other solution as same trouble
filter wheel” 2.Other cause ditto grating motor grating motor
trouble
Display blue 1.LCD is broken 1.Replace the LCD
screen or no 2.Check the connect wire between 2. Reinstall connect wire and
words the LCD and the main board check whether short or not.
3.Connection of 22P socket is loose 3.Replace the socket
4.Display blue screen or no react 4.Replace the main board
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after switch on
Low sucking 1.Check +13.6V and +5V of power 1.Check supply power part or
value or does supply replace power supply
not suck 2.Motor drive chip 3977 is false 2.Re-joint or replace the 3977
sample jointed or broken chip
3.Sucking pipette or pump pipette is 3.Replace sucking pipette or
broken pump pipette
4.The motor is broken 4.Replace the sucking motor
Display 1.The chip 4410 is broken 1.Replace the 4410 chip
temperature 2.Temperature sensor AD590 is 2.Replace the temperature sensor
abnormity broken 3.Reinstall or replace connect
3.The connect wire between the wire
temperature sensor and the main 4.Replace the AD623 chip
board is loose
4.Amplifier AD623 not magnify
multiple
Time can’t 1.Column crystal oscillator 32.768 is 1.Replace column crystal
memorized or broken oscillator
adjust 2.Chip 8563 is broken or false joint 2.Re-joint or replace the 8563
3.3V battery don’t work or socket of chip
battery false joint 3.Replace battery or re-joint
socket of battery
Press sucking 1.Switch of sucking key don’t work 1.Replace switch of sucking key
key can’t suck 2.The connect wire between the 2.Reinstall the connect wire
sample and sucking key and the connecting 3.Replace sucking pipette and
can’t clean board is loose pump pipette
too. 3.Trouble of sucking pipette or 4.Check the connect wire or
pump pipette replace the motor
4.Trouble of sucking motor 5.Re-joint or replace the 3977
5.The 3977 chip of drive board is chip
broken
AD value is 1.Grating motor step with chopping 1.Check motor step
incorrect of wheel motor step is incorrect 2.Check sucking pipette and
each 2.Trouble of liquid circuit pump pipette has leak or not or
wavelength 3.Colorimetric pool has air bubble replace it
4.Trouble of W lamp voltage 3.Use alcohol to clean
colorimetric pool
4.Measure voltage of W lamp
normal range is 11V~12V
Instrument 1.Trouble of 5V of power supply 1.Replace the 4410 chip of the
can’t rise 2.The connect wire between the main board with power board
temperature Peltier and the main board is loose 2.Reinstall the connect wire
3.Trouble of control temperature 3.Replace control temperature
audion audiom
4.Peltier is broken 4.Replace the Piltier

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Part 5 Instrument Maintenance

5.1 Instrument surface cleaning

Use the wet cloth and cleaning agent to clean the instrument. To avoid damage the DOS shell and the
liquid flow into the equipment, prohibit using any corrosive impregnants .

5.2 Colorimetric cuvette cleaning

(1) The colorimetric cuvette should be washed by the cleaning agent or distilled water between each test.
(2) After finish working everyday, wash several times by the cleaning agent to rinse the remains in the
colorimetric cuvette.
(3) To avoid serious contamination, adjust the temperature to 37 to accelerate the cleaning speed, first in
cleaning agent , then in distilled water to wash it several times.
(4) Make sure to maintain some distilled water in the colorimetric cuvette when the equipment stops
working everyday.

5.3 Lamp-house replacement

(1) Turn off power firstly when replacing Lamp-house.
(2) Push the sucking pipette out of the instrument smoothly, and then take down the screw from the
bottom of the instrument. Lift the DOS shell smoothly from the back shell (do not take it off rapidly),
leaving the front on the table. Pull out the sucking pipette from inside completely before DOS shell is
lifted up.
(3) Take off the lampshade and pressure pad first，and then take down the illuminant. (Warning: light bulb
and ambient temperature may be very high, to avoid dangers, please take gloves to do this operation).
(4) Insert the new bulb (12V, 20W) in the lamp stand without touching the top of the light bulb, and then
screw the pressure pad. To avoid effecting the test results ,please do not touch the bulb by hand directly.
Use alcohol cotton to clean it.
(5) Under such circumstance, switch on the power to enter into setup menu ,then press 4 to enter into the
lamp house replacement submenu, according to the reminder info to pump the distilled water and then
the Luminosity value will be shown on the screen.
(6) Adjust the position of lamp-house until the figure on the bottom of the display turned into maximum
( Reference range 18000~50000).
(7) Ensure the figure on the bottom of the display unchanged, and tighten all screws.
(8) Turn off the power, and put on the lampshade. Thus the illuminant replacement is finished.
(9) Insert the pipette properly. Put DOS shell on and tighten all screws.

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 Semi-automatic
automatic Chemistry Analyzer

Figure 5-3-1

5.4 Fuse replacement

The fuse socket is on the back board of the instrument, below the power switch and on the top of the
entrance of electric wire. As shown in Figure 5
5-4-1.
1. Pull out the electric wire, pick off the fuse socket to
replace the fuse offered by manufacturer.

Fuse socket Fuse

Figure 5-4-1

5.5 Pump pipette replacement

Open the DOS shell , the method is same to the lamp
lamp-house replacement (see step1&2). Press the stay bar
to open the block board under the pump, move the pump pipette out and then replace a new one.
To avoid leaking , tighten the screw to tense the pipette properly.

Pump pipette:
Diameter ：2.06mm（inner）
Length：90mm

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 Semi-automatic
automatic Chemistry Analyzer

Stay bar Block board pump bearing

Figure 5-5-1

5.6 Print paper replacement

SPRM printer is provided with paper scroll before leaving factory, but it is not been inserted. This is for the
safety of the printer during the extended transportation and storage. Insert the paper scroll before use, refer
to the following steps:

(1) Press the cover below the paper exit gently, the cover will flick automatically and be open
(2) Cut the paper as Figure 5-6-1.
(3) Switch on the printer power, insert the paper into the paper entrance, it will enter into the crankshaft
automatically.

Figure 5-6-1

5.7 Printer crankshaft maintenance

In order to ensure the normal work of the printer, please do not take the crankshaft down discretionarily.
(1) When replacing the paper, check whether any wastepaper maintains on the crankshaft, blow off it if
there is any.
(2) Ensure the clean of external board
(3) When thermal sensitive printer is dirty ( print results is n
not
ot clear) , clean it with alcohol cotton.
(4) Do not pull the paper emphatically before the crankshaft is put up.
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 Semi-automatic Chemistry Analyzer

The method of using “manufacturer setup” of semi-chemistry analyzer

Step 1 under figure 1 status,
Clear all sample data?

Yes—press enter
No—press exit

Figure 1

Step 2 press “5 1 8 + Enter”, the screen will show as following

1 样本测试 sample test

2 编辑试验参数 edit test parameter
3 质控 quality control
4 设置 set up
5 记录查询 record query
6 冲洗 rinse

Step 3 press 4 设置 (setup)，the screen will show as following

1 语言：中文 Language: Chinese

2 打印机 Printer
3 日期 Date
4 更换电源 press this key, then you can check the luminosity of lamp which
should be more than 10000
5 系统监测 system monitering
6 恢复默认值 resume all default values

Step 4 press 5 系统监测 (system monitoring), the screen will show as following

1 系统调试 system debugging 1 默认值：存储默认值

2 系统监测 system monitoring 2 空气量：000
3 参数输入 parameter input 3 语言选择：中英文
4 泵测试 Pump test

1 default value: save default value

2 air valume: 000
3 language: Chinese/English

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 Semi-automatic Chemistry Analyzer

Step 5 press 1 系统调试 (System debugging)，the screen will show as following

波长 (wavelength) ABS AD
340
405
450
492
505
546
578
630

老化测试 (aging test)

Note: please aspirate distilled water before checking

For wavelength 340. the normal range of AD is from 28000-50000

For wavelength 505 and 750. the normal range of AD is from 19000-50000
For other kinds of wavelength. The normal range is from 20000-50000

All kinds of wavelength for ABS should be less than 5‰

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 Semi-automatic Chemistry Analyzer

After replacing mainboard. It is supposed to set initial values of replaced

mainboard to new mainboard. The steps are as follows

Step 1 under figure 1 status

Clear all sample data?

Yes—press enter
No—press exit

Figure 1

Please input “518+exit”. And then go to next interface

Figure 2

Please input “000”. And then the screen will show as follows

If the third group value is 0000. please change it to be 0041 as shown in the picture. And then press “enter”
to save the change

And then from Figure 2. Please press 4.and then go to the next interface

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 Semi-automatic Chemistry Analyzer

Please press 5 and then go to the next interface

Please press 1 and then go to the next interface

Please place the distilled water under the aspiration tube and then press 4 to go to the next interface.

After the values stop changing. Please press “Enter” to save the values. And then the screen will show
Chinese words “存储完成“(save complete)
And then please go back to the initial interface as shown in figure 2. and input “000”. You can see the
middle value has changed. As the screen shows

And then you can click “exit” to leave the current interface and then restart the instrument

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Appendix B Communication Interface with Computer

Baud rate: 9600；

Data bit: 8 bits
Stop bit: 1 bit
Verification: none；
Hardware hold hands: none
Start character: 02H
2 bytes space: 20H
Line feed character:0DH0AH
Ending character: 03H

Connection between chemistry analyzer and computer：

computer port（RS232） Chemistry analzyer port

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Test report data output format:
（individual data）
1、 Data output format：
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
STX CR LF
SP SP SP SP SP SP SP Report SP Report SP Report SP Report SP Unit CR LF
CR LF
SP date : × × × × - × × - × × SP × × : × × ： × × CR LF
SP Sample No : × × × CR LF
SP Item name ： × × × × × × × × CR LF
SP Reference value ： × × × × × × × × × × × × × × × CR LF
SP Serial No. SP SP SP SP SP Result SP SP SP SP Unit SP SP Reminder info CR LF
SP × × × SP × × × × × × × × × × × × × × × × × SP × × CR LF
CR LF
ETX

Note：
SP------- space character (20h hex)
X--------- virtual value bit
STX----- start character (02h hex)
CR------- return character (0dh hex)
LF-------- line feed character (0ah hex)
ETX------ ending character (03h hex)

（Integrated data）
2、 Data input format：
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
STX CR LF
SP date : × × × × - × × - × × SP × × : × × ： × × CR LF
 DIRUI INDUSRIAL CO., LTD

SP Sample No : × × × CR LF
SP Item name ： × × × × × × × × CR LF
SP Reference value ： × × × × × × × × × × × × × × × CR LF
SP Serial No. SP SP SP SP SP Result SP SP SP SP Unit SP SP Reminder info CR LF
SP × × × SP × × × × × × × × × × × × × × × × × SP SP SP SP × CR LF
CR LF
SP Item name ： × × × × × × × × CR LF
SP Reference value ： × × × × × × × × × × × × × × × CR LF
SP Serial No. SP SP SP SP SP Result SP SP SP SP Unit SP SP Reminder info CR LF
SP × × × SP × × × × × × × × × × × × × × × × × SP × × CR LF
CR LF
……
……
......
......
......
ETX

（QC data ）
3、 Data output format：
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
STX CR LF
SP SP SP SP SP SP SP Report SP Report SP Report SP Report SP Report CR LF
CR LF
SP Date : × × × × - × × - × × SP × × : × × CR LF
SP Item Name ： × × × × × × × × CR LF
SP Lots No. ： × × × × × × × CR LF
SP Standard SP X : × × × × × × × × × CR LF
SP Standard SP S D : × × × × × × × × × CR LF
SP Result ： × × × × × × × CR LF
ETX

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Appendix C Regular Chemistry Reagent List

Code Standard Measuremen Lag time
Parameter Product Methodology Wavelength Temperature Factor Unit Reagent
No. concentration t time(S) (S)
01 ALT Kinetic 340nm 37 ── -3376 U/L 60 60 double reagent
02 GGT Kinetic 405nm 37 ── 1158 U/L 60 60 double reagent
03 ALP Kinetic 405 nm 37 ── 3378 U/L 60 60 double reagent
04 CHE Kinetic 405 nm 37 ── 8369 U/L 60 60 double reagent
05 T-BIL End point 546 nm 37 89.6 ── umol/L ── ── double reagent
06 D-BIL End point 546 nm 37 26 ── umol/L ── ── double reagent
Liver
07 ALB End pint 630 nm 37 40 ── g/L ── ── simple reagent
Function 08 TP End pint 546 nm 37 80 ── g/L ── ── simple reagent
09 NH3 2-point kinetic 340 nm 37 200 ── umol/L ── ── simple reagent
10 AST Kinetic 340 nm 37 ── -3376 U/L 60 60 double reagent
11 LAP Kinetic 405 nm 37 ── 2121 U/L 60 60 double reagent
12 ICDH Kinetic 340 nm 37 ── 3376 U/L 60 120 double reagent
13 ADA Kinetic 340 nm 37 ── 4921 U/L 60 180 double reagent
14 BUN 2-point kinetic 340 nm 37 7.14 ── mmol/L 60 30 double reagent
Kidney
15 Cr 2-point kinetic 505 nm 37 400 ── umol/L 60 30 double reagent
Function 16 UA End point 505 nm room temperature 7.2 ── mmol/L ── ── double reagent
17 Ca End pint 578 nm room temperature 2.5 ── mmol/L ── ── double reagent
18 Ca End pint 630 nm room temperature 2.5 ── mmol/L ── ── simple reagent
19 CI End point 505 nm room temperature 100 ── mmol/L ── ── simple reagent
20 Mg End point 546 nm room temperature 1 ── mmol/L ── ── simple reagent
Hydronium
End point
21 Fe 546 nm room temperature 90 ── umol/L ── ── double reagent
End point simple reagent
22 P 340 nm room temperature 1.29 ── mmol/L ── ──
23 GLU End point 505 nm 37 5.55 ── mmol/L ── ── double reagent
24 GLU End point 340 nm 37 5.55 ── mmol/L ── ── double reagent
Glucose Code Standard Measuremen Lag time
Product Methodology Wavelength Temperature Factor Unit Reagent
metabolism No. concentration t time(S) (S)

25 FTS End point 546 nm 37 1.95 ── mmol/L ── ── simple reagent

26 CHO End point 505 nm 37 7.0 ── mmol/L ── ── double reagent
27 HDL-C End point 546 nm 37 53 ── mmol/L ── ── double reagent
Blood 28 LDL-C End point 546 nm 37 77 ── mmol/L ── ── double reagent
lipoid 29 TG End point 546 nm 37 2.2 mmol/L ── ── double reagent
30 LDH-L Kinetic 340 nm 37 ── 9683 U/L 60 60 double reagent
31 CK Kinetic 340 nm 37 ── 8095 U/L 60 120 double reagent

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32 CK-MB Kinetic 340 nm 37 ── 8254 U/L 60 120 double reagent

33 HBDH Kinetic 340 nm 37 ── 4920 U/L 60 60 double reagent
Kinetic
34 AMY 405 nm 37 ── 5138 U/L 60 60 double reagent
Acute
abdomen Kinetic
35 AMY 405 nm 37 ── 5138 U/L 60 60 double reagent

Note:
1.The above info just for regular items ,for the details, please check the specification on the reagent kits.
2.If needed, user also could program the new parameters according to the specification on the reagent kits.