Neutrophils

most abundant circulating WBC

NK cells- kills cells that fail to display self antigens on their surface
Macrophages- phagocytic sentinel cell

Basophils
Correct answer is releases histamine in response to infection, involved in allergic reactions

Macrophages
Correct answer is sentinel cells that phagocytize foreign substances, dead cells, debris

Eosinophils
Correct answer is has an anti parasitic function

B cells
Correct answer is a lymphocyte processed in bone marrow and responsible for producing
antibodies.

Cytotoxic T-cells
Correct answer is destroy cells infected with intracellular pathogens, made in thymus

NK cells (natural killer cells)

Correct answer is a lymphocyte that kills cells that do not present antigens/proteins (virally
infected/cancerous)

Type 1 hypersensitivity
Correct answer is IgE mediated, triggering mast cell degranulation ex) food/drug allergies

Type 2 hypersensitivity
Correct answer is IgG and IgM antibodies directed against cellular antigens, leads to cell damage
ex) red blood cell damage after transfusion w/ mismatched blood

Type 3 hypersensitivity
Correct answer is immune complexes of IgG and IgM antibodies and antigens are deposited in
tissues, cascades into tissue damage ex) rheumatoid arthritis

Type 4 hypersensitivity
Correct answer is T cell mediated , TH1 cells secrete cytokines, which activate macrophages and
cytotoxic T cells

Which of the following is the type of cell largely responsible for type I hypersensitivity
responses?
a) erythrocyte
b) mast cell
c) T cell
d) antibody
Correct answer is b) mast cell
Type I hypersensitivities require which of the following initial priming events to occur?
a) sensitization
b) secondary immune response
c) cellular trauma
d) degranulation
Correct answer is a) sensitization

Which of the following are the main mediators/initiators of type II hypersensitivity reactions?
a) antibodies
b) mast cells
c) erythrocytes
d) histamines
Correct answer is a) antibodies

Which of the following is a common treatment for type III hypersensitivity reactions?
a) anti-inflammatory steroid treatments
b) antihistamine treatments
c) hyposensitization injections of allergens
d) RhoGAM injections
Correct answer is a) anti-inflammatory steroid treatments

Which of the following is NOT an example of a type 4 hypersensitivity?

a) latex allergy
b) contact dermatitis (contact w/ poison ivy
c) a positive tuberculin skin test
d) hemolytic disease of the newborn
Correct answer is d) hemolytic disease of the newborn

Allergy shots work by shifting antibody responses to produce ________ antibodies.

Correct answer is IgG

Primary immunodeficiency
Correct answer is congenital; usually genetic errors that impair development (antibody
deficiencies)

secondary immunodeficiency
Correct answer is acquired later in life; result of infection (sometimes viral) or other stress on
system (AIDs, malnutrition)

natural active immunity

Correct answer is immunity gained through illness and recovery

natural passive immunity

Correct answer is immunity gained from antibodies through placenta or breastmilk

artificial active immunity

Correct answer is immunity gained through a vaccine

artificial passive immunity