Subject: Science

Grade Level: Grade 10

Objective Explain how mutations may cause changes in the structure and
function of a protein

Learning across curriculum:

1) Mathematics - Understanding the concept of probability in determining the

likelihood of specific mutations occurring in a gene.

2) History - Studying the impact of genetic mutations on historical figures or events,

such as genetic disorders in royal families.

3) English - Analyzing literary works that explore themes of genetic mutations and
their implications on society.

Review Motivation:

[Teaching Strategy: Role-Playing]

[Instructional Materials:]

1) Pictures of famous individuals affected by genetic mutations

2) Genetic mutation case studies

3) Role-playing cards for students to act out scenarios related to protein mutations

Activity 1: Protein Mutation Simulation

[Teaching Strategy: Inquiry-Based Learning]

Materials - Protein models, mutation cards, reference materials

Significance - Understanding how mutations affect protein structure and function

Instructions -

1) Divide students into groups and provide each with a protein model.

2) Students draw a mutation card and simulate the mutation on the protein model.

3) Discuss the changes observed and how they impact protein function.

Rubric - Accuracy of mutation simulation - 15 pts.

Assessment Questions:

1) How did the mutation change the protein structure?

2) What potential effects could this mutation have on the protein's function?

3) How can mutations lead to genetic disorders?

Activity 2: Protein Mutation Case Study Analysis

[Teaching Strategy: Case Studies]

Materials - Case study handouts, laptops for research

Significance - Applying knowledge of protein mutations to real-life scenarios

Instructions -

1) Provide students with a case study of a genetic disorder caused by a protein

mutation.

2) In groups, analyze the case study and identify the specific mutation and its effects.

3) Present findings to the class and discuss the implications of the mutation.

Rubric - Depth of analysis of the mutation - 20 pts.

Assessment Questions:

1) How did the identified mutation alter the protein's function?

2) What are the possible consequences of this mutation on the individual's health?

3) How can genetic counseling help individuals with genetic disorders?

Activity 3: Protein Mutation Debate

[Teaching Strategy: Cooperative Learning]

Materials - Debate topics, research materials

Significance - Encouraging critical thinking and argumentation skills

Instructions -

1) Assign students to pro and con sides of a debate on the ethics of genetic
engineering to correct protein mutations.

2) Research and prepare arguments for the debate.

3) Conduct the debate with each side presenting their viewpoints.

Rubric - Quality of arguments presented - 25 pts.

Assessment Questions:

1) What are the ethical considerations of genetically modifying proteins to correct

mutations?

2) How can societal views on genetic engineering impact research and treatment of
genetic disorders?

3) What are the potential risks and benefits of gene editing technologies?

ANALYSIS:

Activity 1 - Students demonstrated a good understanding of how mutations affect

protein structure through hands-on simulation.

Activity 2 - Students effectively applied their knowledge of protein mutations to

analyze real-life case studies and draw conclusions.

Activity 3 - Students engaged in critical thinking and argumentation skills during the
debate on genetic engineering and protein mutations.

ABSTRACTION:

Mutations in genes can lead to changes in the structure and function of proteins,
which can have significant implications for an individual's health and well-being.
Understanding these mutations is crucial in the fields of genetics and medicine.
APPLICATION:

[Teaching Strategy: Project-Based Learning]

Task 1 - Research and present a project on a specific genetic disorder caused by a

protein mutation, including its symptoms, diagnosis, and treatment options.

Task 2 - Create a visual infographic illustrating the process of protein synthesis and
how mutations can impact protein structure and function.

ASSESSMENT:

[Teaching Strategy: Discussion]

[Instructional Materials:]

Question 1 - How do mutations in a gene lead to changes in the structure of a

protein?

Question 2 - Explain the relationship between protein mutations and genetic

disorders.

Question 3 - Discuss the importance of understanding protein mutations in medical

research and treatment.

Assignment:

1) Watch a documentary on genetic mutations and write a reflection on its

implications for society.

2) Interview a healthcare professional or genetic counselor to learn more about the

role of genetic mutations in healthcare decisions.