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T2-weighted MR images showed a well-demarcated lobular hypointensity 15 mm in size in the right
testis. Figure 2 Sertoli-Leydig cell tumor in a 22-year-old woman with irregular menses and
abdominal swelling. The tumor was confined to the testis and margins were negative. On formalin-
fixed paraffin-embedded (FFPE) sections, the tumor histology showed atypical patterns, and
immunohistochemical analysis was performed in order to determine the type of neoplasm and
differentiate it from other types of testicular tumors, so as to assign. Sertoli-Leydig cell tumors
express general sex cord immunohistochemical markers, such as inhibin and calretinin. Sclerosing
Sertoli cell tumor without expression of typical sex cord stromal tumor markers: Case report and
literature review. Sclerosing sertoli cell tumor of the testis—a case report and review of the literature.
Note entrapped seminiferous tubules lacking spermatogenesis. A thin fibrous capsule often surrounds
the tumor mass. It is well known that accurate diagnosis of str uma ovarii is dif ?cult pre - oper
atively due to i ts non - speci ?c clinical present ation and rare inci - dence, par ticularly in elderly
women. Retrieve Doc Sertoli Cell Tumor In A Pigeon (Columba Livia) - JSTOR RAZMYAR ET
AL?SERTOLI CELL TUMOR IN A PIGEON 287 Figure 1. Large-cell calcifying Sertoli cell tumor
of the testis. An ultrasound showed a 2.1 ? 2.2 cm hypoechogenic, hypervascular tumor in the
middle third of the left testicle. This presentation is in contrast to the large-cell calcifying type of
Sertoli cell tumor that leads to increased estrogen production and gyneco-mastia in 11% to 25% of
reported cases. 9 Metastatic disease has been reported in one patient in a recent series by Kao and
colleagues. 8 This patient presented with metastatic disease to the bone and died of his disease 27
months after presentation. See Full PDF Download PDF See Full PDF Download PDF Related
Papers Therapeutic Advances in Urology The sclerosing Sertoli cell tumor of the testis is an
extremely rare entity KAMRAN BHATTI We present the case of a 31-year-old single male patient,
who was admitted through emergency unit with painless hard nodule of his left testis of 6 months’
duration. The sertoli cells have abundant vacuolated cytoplasm filled with lipid. Extensive sclerosis
is present as compared with focal sclerosis observed in general and large-cell calcifying Sertoli cell
tumors. 1 General Sertoli cell tumors stain positive for cytokeratin, an intermediate filament protein
found in epithelial cells and tumors, in contrast to SSCTs, which are negative for cytokeratin
expression. Serum tumor markers (?-fetoprotein, alkaline phosphatase, ?-human chorionic
gonadotropin, and lactic dehydrogenase) were all within the normal range. Estrogen could not be
extracted from a Sertoli cell tumor that. We present a case of a 23-year-old man diagnosed with
SSCT. Testicular sclerosing Sertoli cell tumor: an additional case and review of the literature. Her
medical histor y had included breast cancer po st radiation and chemotherapy for 12 years and sig
ni?cant for a 30 pack year histor y of smoking, having stopped smoking 2 7 year s prior to present
ation. C T scan revealed intracys tic bladder mas ses and an incidental ?ndin g of a right adnexal
mass. Share to Twitter Share to Facebook Share to Pinterest. Doc Viewer Rat Tumors - Exotic Pets
Lipomas - Also known as a fatty tumor, these growths are exactly what their name implies - fat. This
is a very rare testicular tumor with very few published case reports. Testicular examination revealed
normal volume and consistency bilaterally without other relevant findings. Sertoli cell tumors have
three identified subgroups: large-cell calcifying (LCCSCT), sclerosing Sertoli cell and general type.
On physical examination, he was a well-nourished, well-masculinized young man without
gynecomastia. Expand View on PubMed doi.org Save to Library Save Create Alert Alert Cite Share
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Recency Oxyphilic Sertoli cell tumor of the ovary: a report of three cases, two in patients with the
Peutz-Jeghers syndrome. Judith A. Ferry Robert H. Young George Engel Robert E.
Up to 40% of LCCSCT are associated with the genetic syndromes like Carney complex, Peutz-
Jeghers syndrome. The sertoli cells have abundant vacuolated cytoplasm filled with lipid. Ultrasound
scan of the scrotum showed a fairly well-defined hypo echoic area in the left testicular parenchyma
in its middle part, measuring approximately 10 ? 9 mm in size. Wood’s parasagittal meningioma.40
Hospital-based brain tumor series indicate th. Herein, we report a case of unilateral LCCSCT in a 37
year-old man without any hormonal symptoms or inherited diseases which was succesfully treated
with testis-sparing surgery. Pathologic examination revealed a grossly unifocal, well-circumscribed,
white, firm mass of 0.8 cm. Microscopically the lesion was composed of solid and hollow tubules
and occasional anastomosing cords distributed within the hypocellular, densely collagenous stroma.
Physical examination of the scrotum revealed that both testicles were normal sized with no palpable
mass. Sclerosing Sertoli cell tumor of the testis: a clinicopathologic study of 20 cases. Intraoperative
ultrasound confirmed a superficial 8-mm hypoechoic testis lesion. Types include: Sertoli cell tumour;
Sertoli-Leydig cell tumour; Thecoma; Granulosa cell tumour; Luteoma; Sex cord tumour with
annular tubules; Steroid cell tumor (NOS) Germ cell: Dysgerminoma. It is well known that accurate
diagnosis of str uma ovarii is dif ?cult pre - oper atively due to i ts non - speci ?c clinical present
ation and rare inci - dence, par ticularly in elderly women. They are subclassified as classic, large-cell
calcifying, and sclerosing Sertoli cell tumors (SSCT) based on distinct clinical features. Here, w e
repor t an unusual case of struma ovarii occurred in a 77 years old woman, which is currently known
as the oldest age for this disease. Therefore, getting along with high -gr ade urothe -. A 28-year-old
male visited our hospital with left testis pain. T ransurethral biopsy o f the bladder mass revealed a
high- grade urothelial carcinoma. Her medical histor y had included breast cancer po st radiation and
chemotherapy for 12 years and sig ni?cant for a 30 pack year histor y of smoking, having stopped
smoking 2 7 year s prior to present ation. Only 42 cases of SSCTs have been reported in the
literature. We present a case of a 23-year-old man diagnosed with SSCT. Retrieve Document
Testicular Sertoli Cell Tumor In An Adult - KoreaMed Gan-sparing surgery on the basis of the frozen
biopsy results. Multiple appearances under micr oscope serve as another reason to mislead the
accurat e pathologic evaluation. Sclerosing Sertoli cell tumor without expression of typical sex cord
stromal tumor markers: Case report and literature review. Only 20 cases of sclerosing Sertoli cell
tumours have been encountered. There was no personal or family history of testicular cancer or
cryptorchidism. Note entrapped seminiferous tubules lacking spermatogenesis. Hematoxylin and
eosin stain, original magnification ?40. (B) High-power examination. The frozen section morphologi
- cally show ed sex cord lik e elements and was suspicious f or a sex-cord str omal tumor, probably a
Sertoli cell tumor. After a thorough review of the options, the patient was then taken to the operating
room for inguinal exploration. The tumor was confined to the testis and margins were negative. The
mass was identified during a work-up for transient left testicular discomfort.
Only 42 cases of SSCTs have been reported in the literature. A 28-year-old male visited our hospital
with left testis pain. However, we cannot answer medical or research questions or give advice. The
mass was identified during a work-up for transient left testicular discomfort. The neoplastic cells are
typically large, elongated. A white-yellow, well-demarcated nodule was widely excised and a frozen
section was sent to pathology for examination. Here, w e repor t an unusual case of struma ovarii
occurred in a 77 years old woman, which is currently known as the oldest age for this disease.
Download Free PDF View PDF Case Reports in Pathology Large Cell Calcifying Sertoli Cell Tumor
with Macrocalcification in a Partially Resected Testis Jaudah Al-maghrabi Large cell calcifying
Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date.
Positive for SF1, calretinin, inhibin A, beta catenin (nuclear); negative for SALL4, chromogranin,
synaptophysin. Although the lesion was somewhat well circumscribed, entrapped seminiferous
tubules with Sertoli-only cells were present within the tumor ( Figure 2 ). The frozen section
morphologi - cally show ed sex cord lik e elements and was suspicious f or a sex-cord str omal
tumor, probably a Sertoli cell tumor. Practicing urologists should be familiar with the known subtypes
of SSCT, as these appear amenable to less aggressive surgical therapies such as local excision if the
diagnosis can be confirmed intraoperatively. Distinction among Sertoli cell tumours is important not
only histologically; sclerosing Sertoli cell tumours have a distinct clinical behaviour and prognosis,
different from those of classic and large-cell calcifying Sertoli cell tumours. Ultrasonography
evaluation revealed grade 3 left varicocele and an incidental 9 mm calcified mass in the right
testicle, which was further confirmed by MRI. Tumor cells had pale or eosinophilic cytoplasm with
small and dark nuclei with inconspicuous nucleoli. See Full PDF Download PDF See Full PDF
Download PDF Related Papers Therapeutic Advances in Urology The sclerosing Sertoli cell tumor
of the testis is an extremely rare entity KAMRAN BHATTI We present the case of a 31-year-old
single male patient, who was admitted through emergency unit with painless hard nodule of his left
testis of 6 months’ duration. To date, 43 case reports have been published in the literature including
the case presented here. 1-8 This rare variant of Sertoli cell tumors has been reported exclusively in
postpubertal men ranging in age from 18 to 80 years. This presentation is in contrast to the large-cell
calcifying type of Sertoli cell tumor that leads to increased estrogen production and gyneco-mastia in
11% to 25% of reported cases. 9 Metastatic disease has been reported in one patient in a recent
series by Kao and colleagues. 8 This patient presented with metastatic disease to the bone and died
of his disease 27 months after presentation. To browse Academia.edu and the wider internet faster
and more securely, please take a few seconds to upgrade your browser. Testicular sclerosing Sertoli
cell tumor: an additional case and review of the literature. Loss of fertility and moderate discolor-
ation of the feathers had been observed for a. Pathologic examination revealed a grossly unifocal,
well-circumscribed, white, firm mass of 0.8 cm. Microscopically the lesion was composed of solid
and hollow tubules and occasional anastomosing cords distributed within the hypocellular, densely
collagenous stroma. Retrieve Document Testicular Sertoli Cell Tumor In An Adult - KoreaMed Gan-
sparing surgery on the basis of the frozen biopsy results. Ultrasound scan of the scrotum showed a
fairly well-defined hypo echoic area in the left testicular parenchyma in its middle part, measuring
approximately 10 ? 9 mm in size. Only 20 cases of sclerosing Sertoli cell tumours have been
encountered. Estrogen could not be extracted from a Sertoli cell tumor that. They usually occur in
boys and young adults and can affect one or both testicles in multifocal form causing
microcalcifications. All cases have been reported as unilateral without evidence of feminization or
extra-testicular manifestations. There are many different tumor markers, each indicative of a
particular disease process, and they are used in oncology to help detect the presence of cancer.. Read
Article Sertoli Cell Tumor Associated With Polyomavirus Infection In. They are subclassified as
classic, large-cell calcifying, and sclerosing Sertoli cell tumors (SSCT) based on distinct clinical
features.
Testicular examination revealed normal volume and consistency bilaterally without other relevant
findings. The tumor is positive for SF1, nuclear beta catenin, androgen receptor, variable for inhibin
A and calretinin and negative for SALL4. This presentation is in contrast to the large-cell calcifying
type of Sertoli cell tumor that leads to increased estrogen production and gyneco-mastia in 11% to
25% of reported cases. 9 Metastatic disease has been reported in one patient in a recent series by
Kao and colleagues. 8 This patient presented with metastatic disease to the bone and died of his
disease 27 months after presentation. Speci ?cally, the CT sc an showed, in the right adnexa, an 8 x 5
x 5cm solid, sof t tis sue attenu - ation mas s with s ome ass ociated c alci?cation s as well a 2. 6 cm
c ysti c component, and moder - ate pelvic as cites was note d. Serum tumor markers (?-fetoprotein,
alkaline phosphatase, ?-human chorionic gonadotropin, and lactic dehydrogenase) were all within the
normal range. This is a very rare testicular tumor with very few published case reports. We present a
case of a 23-year-old man diagnosed with SSCT. See Full PDF Download PDF See Full PDF
Download PDF Related Papers Therapeutic Advances in Urology The sclerosing Sertoli cell tumor
of the testis is an extremely rare entity KAMRAN BHATTI We present the case of a 31-year-old
single male patient, who was admitted through emergency unit with painless hard nodule of his left
testis of 6 months’ duration. The frozen section morphologi - cally show ed sex cord lik e elements
and was suspicious f or a sex-cord str omal tumor, probably a Sertoli cell tumor. Tumor enucleation
was performed, and the tumor was diagnosed as a sclerosing Sertoli cell tumor. Levels of the tumor
markers AFP, hCG, and LDH were all within the standard ranges. Doc Viewer Rat Tumors - Exotic
Pets Lipomas - Also known as a fatty tumor, these growths are exactly what their name implies - fat.
Tumor cells had pale or eosinophilic cytoplasm with small and dark nuclei with inconspicuous
nucleoli. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the
Allen Institute for AI. In a recent large case series, all moderately and poorly differentiated Sertoli-
Leydig cell tumors harbored DICER1 mutations. Although the lesion was somewhat well
circumscribed, entrapped seminiferous tubules with Sertoli-only cells were present within the tumor (
Figure 2 ). Sertoli cell tumor, and a similar tendency to label other neoplasms as Sertoli cell tumors
that would be best placed in other categories, retroperitoneal mass, and while slightly missing the
large size criterion for pathologic malignancy. View This Document Interstitial Cell Tumor And
Sertoli Cell Tumor In The Testis. All cases have been reported as unilateral without evidence of
feminization or extra-testicular manifestations. They usually occur in boys and young adults and can
affect one or both testicles in multifocal form causing microcalcifications. Share to Twitter Share to
Facebook Share to Pinterest. Physical examination of the scrotum revealed that both testicles were
normal sized with no palpable mass. Contrast enhancement of this mass after gadolinium
administration was homogeneous, with slightly stronger enhancement than the normal testis tissue.
SSCT is characterized by the presence and aggregates of tubules of Sertoli cells, separated by a
sclerotic intercellular matrix formed by fibrotic connective tissue. However, we cannot answer
medical or research questions or give advice. The tumor was confined to the testis and margins were
negative. Read Article Ovarian Sertoli Leydig cell tumors: MRI Findings And. Pathologic
examination revealed a grossly unifocal, well-circumscribed, white, firm mass of 0.8 cm.
Microscopically the lesion was composed of solid and hollow tubules and occasional anastomosing
cords distributed within the hypocellular, densely collagenous stroma. His only notable medical
history was nephrolithiasis.
Distinction among Sertoli cell tumours is important not only histologically; sclerosing Sertoli cell
tumours have a distinct clinical behaviour and prognosis, different from those of classic and large-
cell calcifying Sertoli cell tumours. To browse Academia.edu and the wider internet faster and more
securely, please take a few seconds to upgrade your browser. Testicular sertoli cell tumours and
relative sub-types. Such extratesticular manifestations have never been described in the sclerosing
subtype, further supporting the clinical significance of the specific subtype assigned to Sertoli cell
tumors. We welcome suggestions or questions about using the website. Final pathological diagnosis
was con?rmed as struma ov arii based on the typical morphologic thyroid follicles and
immunohistochemical staining results. Because the final diagnosis could not be determined from
frozen section, the decision was made to perform a right radical orchiectomy. Contrast enhancement
of this mass after gadolinium administration was homogeneous, with slightly stronger enhancement
than the normal testis tissue. However, we cannot answer medical or research questions or give
advice. Clinical data, radiological studies, and morphological and immunohistochemical
characteristics were analyzed. Note entrapped seminiferous tubules lacking spermatogenesis.
Ultrasound scan of the scrotum showed a fairly well-defined hypo echoic area in the left testicular
parenchyma in its middle part, measuring approximately 10 ? 9 mm in size. You can download the
paper by clicking the button above. Up to 40% of LCCSCT are associated with the genetic
syndromes like Carney complex, Peutz-Jeghers syndrome. Sertoli-Leydig cell tumors express general
sex cord immunohistochemical markers, such as inhibin and calretinin. Tumor cells had pale or
eosinophilic cytoplasm with small and dark nuclei with inconspicuous nucleoli. Positive for SF1,
calretinin, inhibin A, beta catenin (nuclear); negative for SALL4, chromogranin, synaptophysin.
Sclerosing sertoli cell tumor of the testis—a case report and review of the literature. Speci ?cally, the
CT sc an showed, in the right adnexa, an 8 x 5 x 5cm solid, sof t tis sue attenu - ation mas s with s
ome ass ociated c alci?cation s as well a 2. 6 cm c ysti c component, and moder - ate pelvic as cites
was note d. Read Article Ovarian Sertoli Leydig cell tumors: MRI Findings And. Only 20 cases of
sclerosing Sertoli cell tumours have been encountered. See Full PDF Download PDF See Full PDF
Download PDF Related Papers Therapeutic Advances in Urology The sclerosing Sertoli cell tumor
of the testis is an extremely rare entity KAMRAN BHATTI We present the case of a 31-year-old
single male patient, who was admitted through emergency unit with painless hard nodule of his left
testis of 6 months’ duration. Get Document Malignant Sertoli Cell Tumor Of The Testis With A
Large. The frozen section morphologi - cally show ed sex cord lik e elements and was suspicious f or
a sex-cord str omal tumor, probably a Sertoli cell tumor. This is a very rare testicular tumor with very
few published case reports. A 28-year-old male presented to the urology department of our hospital
complaining of a painless mass in the right testicle that had been present for the past 2 years. T2-
weighted MR images showed a well-demarcated lobular hypointensity 15 mm in size in the right
testis. Intraoperative ultrasound confirmed a superficial 8-mm hypoechoic testis lesion. Most of the
tumors are benign with a few malignant cases, and aggressive behavior is infrequent.
Download Free PDF View PDF Case Reports in Pathology Large Cell Calcifying Sertoli Cell Tumor
with Macrocalcification in a Partially Resected Testis Jaudah Al-maghrabi Large cell calcifying
Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date.
Extensive sclerosis is present as compared with focal sclerosis observed in general and large-cell
calcifying Sertoli cell tumors. 1 General Sertoli cell tumors stain positive for cytokeratin, an
intermediate filament protein found in epithelial cells and tumors, in contrast to SSCTs, which are
negative for cytokeratin expression. Her medical histor y had included breast cancer po st radiation
and chemotherapy for 12 years and sig ni?cant for a 30 pack year histor y of smoking, having
stopped smoking 2 7 year s prior to present ation. Read Article Ovarian Sertoli Leydig cell tumors:
MRI Findings And. Clinical data, radiological studies, and morphological and immunohistochemical
characteristics were analyzed. Computed tomography scan of the abdomen and pelvis and chest
radiograph were negative for metastatic disease. The sertoli cells have abundant vacuolated
cytoplasm filled with lipid. Only 1% of these tumors are pure Sertoli cell tumors. The mass was
identified during a work-up for transient left testicular discomfort. T ransurethral biopsy o f the
bladder mass revealed a high- grade urothelial carcinoma. Our case, a 38-year-old man represents the
21st case. Distinction among Sertoli cell tumours is important not only histologically; sclerosing
Sertoli cell tumours have a distinct clinical behaviour and prognosis, different from those of classic
and large-cell calcifying Sertoli cell tumours. Only 42 cases of SSCTs have been reported in the
literature. Loss of fertility and moderate discolor- ation of the feathers had been observed for a. See
Full PDF Download PDF See Full PDF Download PDF Related Papers Therapeutic Advances in
Urology The sclerosing Sertoli cell tumor of the testis is an extremely rare entity KAMRAN BHATTI
We present the case of a 31-year-old single male patient, who was admitted through emergency unit
with painless hard nodule of his left testis of 6 months’ duration. We present a case of a 23-year-old
man diagnosed with SSCT. Rapid microscopic evaluation of fresh frozen sections during the
operation was inconclusive, which led to a decision not to perform a radical orchiectomy
immediately. However, we cannot answer medical or research questions or give advice. Doc Viewer
Rat Tumors - Exotic Pets Lipomas - Also known as a fatty tumor, these growths are exactly what
their name implies - fat. Retrieve Doc Sertoli Cell Tumor In A Pigeon (Columba Livia) - JSTOR
RAZMYAR ET AL?SERTOLI CELL TUMOR IN A PIGEON 287 Figure 1. Note entrapped
seminiferous tubules lacking spermatogenesis. Sertoli cell tumors have three identified subgroups:
large-cell calcifying (LCCSCT), sclerosing Sertoli cell and general type. Pathologic examination
revealed a grossly unifocal, well-circumscribed, white, firm mass of 0.8 cm. Microscopically the
lesion was composed of solid and hollow tubules and occasional anastomosing cords distributed
within the hypocellular, densely collagenous stroma. Testicular examination revealed normal volume
and consistency bilaterally without other relevant findings. Testicular sclerosing Sertoli cell tumor: an
additional case and review of the literature. Return Document CANINE SERTOLI CELL TUMOR:
CASE REPORT The Sertoli cell tumor is generally the firmest of the canine testicular tumors.
Estrogen could not be extracted from a Sertoli cell tumor that. The frozen section morphologi - cally
show ed sex cord lik e elements and was suspicious f or a sex-cord str omal tumor, probably a
Sertoli cell tumor. Types include: Sertoli cell tumour; Sertoli-Leydig cell tumour; Thecoma; Granulosa
cell tumour; Luteoma; Sex cord tumour with annular tubules; Steroid cell tumor (NOS) Germ cell:
Dysgerminoma. The frozen section examination revealed the lesion to be a neoplasm with differential
diagnosis including sclerosing Sertoli cell tumor (SSCT), adenomatoid tumor, and a variant of Leydig
cell tumor.