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  • TUTORIAL On Membrane Potential NMJ and MUScle PGY310

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    The document contains tutorial questions covering several topics in neurophysiology including: 1) The resting membrane potential of neurons, how it is recorded, and what causes it. 2) The nerve action potential including its phases and how it is propagated along nerve fibers. 3) The neuromuscular junction including its structure, transmission of nerve impulses, and drugs that affect it. 4) Muscle physiology including the different muscle types, proteins, sarcomere structure, mechanisms of contraction, factors affecting tension, and muscle fatigue.

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    TUTORIAL on Membrane Potential NMJ and MUScle PGY310

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    The document contains tutorial questions covering several topics in neurophysiology including: 1) The resting membrane potential of neurons, how it is recorded, and what causes it. 2) The nerve action potential including its phases and how it is propagated along nerve fibers. 3) The neuromuscular junction including its structure, transmission of nerve impulses, and drugs that affect it. 4) Muscle physiology including the different muscle types, proteins, sarcomere structure, mechanisms of contraction, factors affecting tension, and muscle fatigue.

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    © All Rights Reserved
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    1 views3 pages

    TUTORIAL On Membrane Potential NMJ and MUScle PGY310

    Uploaded by

    nindidavid628
    The document contains tutorial questions covering several topics in neurophysiology including: 1) The resting membrane potential of neurons, how it is recorded, and what causes it. 2) The nerve action potential including its phases and how it is propagated along nerve fibers. 3) The neuromuscular junction including its structure, transmission of nerve impulses, and drugs that affect it. 4) Muscle physiology including the different muscle types, proteins, sarcomere structure, mechanisms of contraction, factors affecting tension, and muscle fatigue.

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    © All Rights Reserved
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    of 3

    Mbchb 3-1; EDEN UNIVERSITY ZAMBIA

    TUTORIAL QUESTIONs

    NEURONE
    1) What is a resting membrane potential? How is it recorded?
    2) What is the basic cause of production of resting membrane potential?
    3) Calculate Nernst potentials for K+ and Na+ ions
    4) Study the diagram below and answer question a, b and c. Match each of
    the descriptions to one of the points of the nerve action potential shown in
    the diagram.

    A. Point at which the membrane potential (Vm) is closest to the Na+


    equilibrium potential: ………………………..

    1
    B. Point at which the driving force for Na+ is the
    greatest: ……………………………………….
    C. Point at which the ratio of K+ permeability to Na+ permeability
    (PK/PNa) is the greatest: ………………………..

    5. How much is the resting membrane potential of the nerve fibre


    6. what is action potential? AND NAME THE PHASES of an action potential
    7. How does nerve fibre get depolarized?
    8. What is repolarization? How does repolarization occur?
    9. How is action potential propagated?
    10. Describe the instrument used for recording action potential.

    NEUROMUSCULAR JUNCTION
    1) Describe the structure of neuromuscular junction.
    2) Give sequence of events which causes transmission of impulse through
    neuromuscular junction.
    3) Describe any 5 drugs DRUGS AFFECTING NEUROMUSCULAR JUNCTION
    4) What is myasthenia gravis? What is its probable cause?
    5) What is rigour mortis? What is it due to? Is it reversible?

    2
    MUSCLE PHYSIOLOGY
    1. What is muscle? Name the different types of muscles
    2. Enumerate the different muscle proteins
    3. What is a sarcomere? Describe the structure
    4. Describe the structure of actin and myosin filaments.
    5. What is the role of regulatory proteins in the skeletal muscle contraction?
    6. What are cross-bridges? What is sarcoplasmic triad?
    7. What is the mechanism of excitation-contraction coupling in skeletal
    muscle fibres?
    8. Describe the modern theory of muscle contraction?
    9. What are the functions of ATP in skeletal muscle contraction?
    10. Describe the factors determining muscle tension
    11. What is tetanus? What is the mechanism which causes tetanus?
    12. What is muscle fatigue? What is the mechanism by which fatigue occurs?

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