METABOLISM

Dr. Nguyen Thi

Hoang Yen
 d hóa

ng hóa( khi no)

CATABOLISM ANABOLISM

- Definition
- When do they happen?
- Ex: substances, hormones
- Function of GLUT (glucose transporter)
CATABOLISM ANABOLISM

?
hai cái bng nhau gi là: basil metalxlicrate
 PROTEINS

Short-life span Long-life span

- Definition
- Ex:

NITROGEN BALANCE
Positive Negative
- Definition
- Ex:
 ESSENTIAL AMINO ACID
9 amino acids: ?
When is there a deficiency of essential amino acids?
b thíu essential là negative
 CARBOHYDRATES
Digesting carbohydrates for what?
• Glucose metabolism gm TCA,....

• Storage (form, where) di gluco chuyn hóa thành m d tr mô m

dng lycogen
 LIPID
Digesting lipid for what? (3)
• Lipid metabolism
• Storage (form, where)
• Malnutrition

in US In poor countries

Kwashiorkor Marasmus
ch íu ung sa
n ch íu tinh bôt
b phù, nhìu ng xong chuyn thành m thíu mu
REGULATION OF METABOLISM

Enzymes

1. Allosteric control
2. Phosphorylation/
dephosphorylation
3. Long-term
metabolism response
 Food METABOLISM AFTER EATING

Intestine cells

Hepatic portal
vein

[glu]
In Liver xy ra: tng hp protein
[aa]
insulin lipid i theo h thng khác
Other organs
glucagon
 OBESITY
BMI = Cân nặng/(Chiều cao)2

Diabetes
Metabolic syndrome
Hypertension
or syndrome X
Cardiovascular dis.

Fat accumulates in organs  dyslipidemia  cardiovascular dis.

Treatment: change lifestyle/gastric by-pass surgery

 METABOLISM IN THE FASTING STATE
4-24h after last meal:
1. [glu]?
2. [insulin]/[glucagon]?
3. Organs: liver, adipose tissue, muscle, brain
 METABOLISM IN THE STARVATION
[insulin] Cortisol Muscle:
[glucagon] protein degradation
10-14 days

Glucose
Ketone bodies
> 15 days

Contractile