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THE
HARRIET LANE
HANDBOOK
TWENTY-FIRST EDITION
The Harriet Lane Service at
The Charlotte R. Bloomberg Children’s Center of
The Johns Hopkins Hospital
EDITORS
HELEN K. HUGHES, MD, MPH
LAUREN K. KAHL, MD
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
THE HARRIET LANE HANDBOOK, 21ST EDITION ISBN: 978-0-323-39955-5
INTERNATIONAL EDITION ISBN: 978-0-323-47373-6
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Notices
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Previous editions copyrighted 2015, 2012, 2009, 2005, 2002, 2000, 1996, 1993, 1991, 1987,
1984, 1981, 1978, 1975, 1972, and 1969.
Library of Congress Cataloging-in-Publication Data
Names: Harriet Lane Service (Johns Hopkins Hospital), author. | Hughes, Helen (Helen Kinsman),
editor. | Kahl, Lauren, editor.
Title: The Harriet Lane handbook : a manual for pediatric house officers / The Harriet Lane Service
at The Charlotte R. Bloomberg Children’s Center of The Johns Hopkins Hospital ; editors, Helen
Hughes, Lauren Kahl.
Description: Twenty-first edition. | Philadelphia, PA : Elsevier, [2018] | Includes bibliographical
references and index.
Identifiers: LCCN 2016048390 | ISBN 9780323399555 (pbk. : alk. paper) |
ISBN 9780323473736 (international edition)
Subjects: | MESH: Pediatrics | Handbooks
Classification: LCC RJ48 | NLM WS 29 | DDC 618.92—dc23 LC record available at
https://lccn.loc.gov/2016048390
Executive Content Strategist: Jim Merritt Senior Project Manager: Cindy Thoms
Senior Content Development Specialist: Jennifer Ehlers Book Designer: Ashley Miner
Publishing Services Manager: Patricia Tannian
Printed in United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To our families
Emily Fairchild, you are my selfless champion,
cheerleader, and role model. Stephen
Kinsman, thank you for giving me your
unwavering support and infectious love of
pediatrics. Andrew Hughes, you have given
me a better life—and family—than I ever
thought possible. Oliver, you are the light of
my life.
To our residents
We are inspired daily by your hard work,
resilience, and commitment to this noble
profession.
And to
Tina Cheng,
Pediatrician-in-Chief,
The Johns Hopkins Hospital,
Fearless advocate for children, adolescents,
and families
Residents Interns
Ifunanya Agbim Megan Askew
Suzanne Al-Hamad Brittany Badesch
Madeleine Alvin Samantha Bapty
Caren Armstrong Jeanette Beaudry
Stephanie Baker Victor Benevenuto
Mariju Baluyot Eva Catenaccio
Justin Berk Kristen Cercone
Alissa Cerny Danielle deCampo
Kristen Coletti Caroline DeBoer
John Creagh Jonathan Eisenberg
Matthew DiGiusto Amnha Elusta
Dana Furstenau Lucas Falco
Zachary Gitlin RaeLynn Forsyth
Meghan Kiley Hanae Fujii-Rios
Keith Kleinman Samuel Gottlieb
Theodore Kouo Deborah Hall
Cecilia Kwak Stephanie Hanke
Jasmine Lee-Barber Brooke Krbec
Laura Livaditis Marguerite Lloyd
Laura Malone Nethra Madurai
Lauren McDaniel Azeem Muritala
Matthew Molloy Anisha Nadkarni
Joseph Muller Chioma Nnamdi-Emetarom
Keren Muller Maxine Pottenger
Robin Ortiz Jessica Ratner
Chetna Pande Harita Shah
Thomas Rappold Soha Shah
Emily Stryker Rachel Troch
Claudia Suarez-Makotsi Jo Wilson
Jaclyn Tamaroff Philip Zegelbone
Lindy Zhang
Helen K. Hughes
Lauren K. Kahl
GLASGOW COMA SCALE
Activity Score Child/Adult Score Infant
Eye opening 4 Spontaneous 4 Spontaneous
3 To speech 3 To speech/sound
2 To pain 2 To painful stimuli
1 None 1 None
Verbal 5 Oriented 5 Coos/babbles
4 Confused 4 Irritable cry
3 Inappropriate 3 Cries to pain
2 Incomprehensible 2 Moans to pain
1 None 1 None
Motor 6 Obeys commands 6 Normal spontaneous movement
5 Localizes to pain 5 Withdraws to touch
4 Withdraws to pain 4 Withdraws to pain
3 Abnormal flexion 3 Abnormal flexion (decorticate)
2 Abnormal extension 2 Abnormal extension (decerebrate)
1 None 1 None (flaccid)
Adapted from Hunt EA, Nelson-McMillan K, McNamara L. The Johns Hopkins Children’s Center Kids Kard, 2016.
Desired dose (mcg/kg/min) mg drug
IV INFUSIONS* 6 ¥ ¥ Wt (kg) =
Desired rate (mL/hr) 100 mL fluid
Dilution in 100 mL in
Medication Dose (mcg/kg/min) a Compatible IV Fluid IV Infusion Rate
Alprostadil (prostaglandin E1) 0.05–0.1 0.3 mg/kg 1 mL/hr = 0.05 mcg/kg/min
Amiodarone 5–15 6 mg/kg 1 mL/hr = 1 mcg/kg/min
DOPamine 5–20 6 mg/kg 1 mL/hr = 1 mcg/kg/min
DOBUTamine 2–20 6 mg/kg 1 mL/hr = 1 mcg/kg/min
EPINEPHrine 0.01–0.2, up to 1 in severe 0.6 mg/kg 1 mL/hr = 0.1 mcg/kg/min
circumstances
Lidocaine, post resuscitation 20–50 6 mg/kg 1 mL/hr = 1 mcg/kg/min
Phenylephrine 0.05–2, up to 5 in severe 0.3 mg/kg 1 mL/hr = 0.05 mcg/kg/min
circumstances
Terbutaline 0.1–4 (up to 10 has been used) 0.6 mg/kg 1 mL/hr = 0.1 mcg/kg/min
Vasopressin (pressor) 0.5–2 milliunits/kg/min 6 milliunits/kg 1 mL/hr = 1 milliunit/kg/min
*Standardized concentrations are recommended when available. For additional information, see Larsen GY, Park HB et. al.
Standard drug concentrations and smart-pump technology reduce continuous-medication-infusion errors in pediatric
patients. Pediatrics. 2005; 116(1):e21-e25.
RESUSCITATION MEDICATIONS
Adenosine 0.1 mg/kg IV/IO RAPID BOLUS (over 1-2 sec), Flush with 10 mL normal saline
Supraventricular tachycardia May repeat at 0.2 mg/kg IV/IO, then 0.3 mg/kg IV/IO after 2 min
Max first dose 6 mg, max subsequent dose 12 mg
Administer using a 3-way stopcock attached to a 10 ml NS flush
Amiodarone 5 mg/kg IV/IO
Ventricular tachycardia No Pulse: Push Undiluted
Ventricular fibrillation Pulse: Dilute and give over 20-60 minutes
Max first dose 300 mg, max subsequent dose 150 mg
Monitor for hypotension
Strongly consider pretreating with IV calcium in patients with a pulse
to prevent hypotension
Atropine 0.02 mg/kg IV/IO/IM, 0.04–0.06 mg/kg ETT
Bradycardia (increased vagal tone) Max single dose 0.5 mg
Primary AV block Repeat in 5 minutes if needed (up to twice) to max total dose 1 mg
Calcium chloride (10%) 20 mg/kg IV/IO
Hypocalcemia Max dose 1 gram
Calcium Gluconate (10%) 60 mg/kg IV/IO
Max dose 3 grams
Dextrose <5 kg: 10% dextrose 10 mL/kg IV/IO
5-44 kg: 25% dextrose 4 mL/kg IV/IO
≥45 kg: 50% dextrose 2 mL/kg IV/IO, max single dose 50 grams = 100 mL
Epinephrine 0.01 mg/kg (0.1 mL/kg) 1:10,000 IV/IO every 3–5 min (max single dose 1 mg)
Pulseless arrest 0.1 mg/kg (0.1 mL/kg) 1:1000 ETT every 3–5 min (max single dose 2.5 mg)
Bradycardia (symptomatic) Anaphylaxis: 0.01 mg/kg (0.01 mL/kg) of 1:1000 IM (1 mg/mL) in thigh
Anaphylaxis every 5-15 min PRN; max single dose 0.5 mg
Standardized/Autoinjector:
<10 kg: no Autoinjector, see above
10-30 kg: 0.15 mg IM
>30 kg: 0.3 mg IM
Insulin (Regular or Aspart) 0.1 units/kg IV/IO with 0.5 gram/kg of dextrose
Hyperkalemia Max single dose 10 units
Magnesium sulfate 50 mg/kg IV/IO
Torsades de pointes No Pulse: Push
Hypomagnesemia Pulse: Give over 20-60 minutes
Max single dose 2 grams
Monitor for hypotension/bradycardia
Naloxone Respiratory Depression: 0.001-0.005 mg/kg/dose IV/IO/IM/Subcut (max
Opioid overdose 0.1 mg first dose, may titrate to effect)
Coma Full Reversal/Arrest Dose: 0.1 mg/kg IV/IO/IM/Subcut (max dose 2 mg)
ETT dose 2–3 times IV dose. May give every 2 min PRN
Sodium Bicarbonate (8.4% = 1 mEq/mL) 1 mEq/kg IV/IO
Administer only with clear indication: Dilute 8.4% sodium bicarbonate 1 : 1 with sterile water for patients
Metabolic acidosis <10 kg to a final concentration of 4.2% = 0.5 mEq/mL
Hyperkalemia Hyperkalemia: Max single dose 50 mEq
Tricyclic antidepressant overdose
Vasopressin 0.4 units/kg/dose IV/IO
Max single dose 40 units
ETT Meds (NAVEL: naloxone, atropine, vasopressin, epinephrine, lidocaine)—dilute meds to 5 mL with NS, follow with
positive-pressure ventilation.
Special thanks to LeAnn McNamara, Clinical Pharmacy Specialist, and Elizabeth A. Hunt, MD, MPH, PhD, for their expert
guidance with IV infusion and resuscitation medication guidelines.
Adapted from Hunt EA, Nelson-McMillan K, McNamara L. The Johns Hopkins Children’s Center Kids Kard, 2016 and the
American Heart Association, PALS Pocket Card, 2010.
Chapter 1
Emergency Management
Vanessa Ozomaro Jeffries, MD
I. CIRCULATION2-9
A. Assessment
1. Perfusion:
a. Assess pulse: If infant/child is unresponsive and not breathing (gasps
do not count as breathing), healthcare providers may take up to 10
seconds to feel for pulse (brachial in infants, carotid/femoral in
children).2
(1) If pulseless, immediately begin chest compressions (see
Circulation, B.1).
(2) If pulse, begin A-B-C pathway of evaluation.
b. Assess capillary refill (<2 s = normal, 2 to 5 s = delayed, and >5 s
suggests shock), mentation, and urine output (if urinary catheter in
place).
2. Rate/rhythm: Assess for bradycardia, tachycardia, abnormal rhythm, or
asystole. Generally, bradycardia requiring chest compressions is <60
beats/min; tachycardia of >220 beats/min suggests tachyarrhythmia
rather than sinus tachycardia.
3. Blood pressure (BP): Hypotension is a late manifestation of circulatory
compromise. Can be calculated in children >1 year with following
formula:
Hypotension = Systolic BP < [70 + (2 × age in years)]
2
Chapter 1 Emergency Management 3
TABLE 1.1
MANAGEMENT OF CIRCULATION3-5
1
Infants Prepubertal Children Adolescents/Adults
Location 1 fingerbreadth below 2 fingerbreadths below Lower half of sternum
intermammary line intermammary line
Rate 100–120 per minute — —
Depth* 1 1 2 inches (4 cm) 2 inches (5 cm) 2–2.4 inches (5 cm)
Compressions: 15:2 (2 rescuers) 15:2 (2 rescuers) 30:2 (1 or 2 rescuers)
Ventilation† 30:2 (1 rescuer) 30:2 (1 rescuer)
*Depth of compressions should be at least one-third of anteroposterior diameter of the chest. Depth values are
approximations for most infants and children.
†
If intubated, give one breath every 6–8 seconds (8–10/min) without interrupting chest compressions. If there is return
of spontaneous circulation, give one breath every 3–5 seconds.
II. AIRWAY7-10
A. Assessment
1. Assess airway patency; think about obstruction: Head tilt/chin lift (or
jaw thrust if injury suspected) to open airway. Avoid overextension in
infants, as this may occlude airway.
2. Assess for spontaneous respiration: If no spontaneous respirations,
begin ventilating via rescue breaths, bag-mask, or endotracheal tube.
3. Assess adequacy of respirations:
a. Look for chest rise.
b. Recognize signs of distress (grunting, stridor, tachypnea, flaring,
retractions, accessory muscle use, wheezes).
B. Management7-17
1. Equipment
a. Bag-mask ventilation may be used indefinitely if ventilating effectively
(look at chest rise). Cricoid pressure (Sellick maneuver) can be used
to minimize gastric inflation and aspiration; however, excessive use
should be avoided as to not obstruct the trachea.
b. If available, consider EtCO2 as measure of effective ventilation.
c. Use oral or nasopharyngeal airway in patients with obstruction:
(1) Oral: Unconscious patients—measure from corner of mouth to
mandibular angle.
(2) Nasal: Conscious patients—measure from tip of nose to tragus of
ear.
d. Laryngeal mask airway: Simple way to secure an airway (no
laryngoscopy needed), especially in difficult airways; does not prevent
aspiration.
2. Intubation: Indicated for (impending) respiratory failure, obstruction,
airway protection, pharmacotherapy, or need for likely prolonged
support
a. Equipment: SOAP-ME (Suction, Oxygen, Airway Supplies,
Pharmacology, Monitoring Equipment)
(1) Laryngoscope blade:
(a) Miller (straight blade):
(i) #00–1 for premature to 2 months
(ii) #1 for 3 months to 3 years
(iii) #2 for >3 years
Chapter 1 Emergency Management 5
1
(2) Endotracheal tube (ETT): Both cuffed and uncuffed ETT are
acceptable, but cuffed is preferred in certain populations (i.e.,
poor lung compliance, high airway resistance, glottic air leak, or
between ages 1–2 years)
(a) Size determination:
(i) Cuffed ETT (mm) = (age/4) + 3.5
(ii) Uncuffed ETT (mm) = (age/4) + 4
(iii) Use length-based resuscitation tape to estimate
(b) Approximate depth of insertion in cm = ETT size × 3
(c) Stylet should not extend beyond the distal end of the ETT
(d) Attach end-tidal CO2 monitor as confirmation of placement
and effectiveness of chest compressions if applicable
(3) Nasogastric tube (NGT): To decompress the stomach; measure
from nose to angle of jaw to xiphoid for depth of insertion
b. Rapid sequence intubation (RSI) recommended for aspiration risk:
(1) Preoxygenate with nonrebreather at 100% O2 for minimum of 3
minutes:
(a) Do not use positive-pressure ventilation (PPV) unless patient
effort is inadequate
(b) Children have less oxygen/respiratory reserve than adults,
owing to higher oxygen consumption and lower functional
residual capacity
(2) See Fig. 1.1 and Table 1.2 for drugs used for RSI (adjunct,
sedative, paralytic). Important considerations in choosing
appropriate agents include clinical scenario, allergies, presence of
neuromuscular disease, anatomic abnormalities, or hemodynamic
status.
(3) For patients who are difficult to mask ventilate or have difficult
airways, consider sedation without paralysis and the assistance of
subspecialists (anesthesiology and otolaryngology).
c. Procedure (attempts should not exceed 30 seconds):
(1) Preoxygenate with 100% O2.
(2) Administer intubation medications (see Fig. 1.1 and Table 1.1).
(3) Use of cricoid pressure to prevent aspiration during bag-valve-
mask ventilation and intubation is optional. (Note: No benefit of
cricoid pressure has been demonstrated. Do not continue if it
interferes with ventilation or speed of intubation.)
(4) Use scissoring technique to open mouth.
(5) Hold laryngoscope blade in left hand. Insert blade into right side
of mouth, sweeping tongue to the left out of line of vision.
(6) Advance blade to epiglottis. With straight blade, lift up, directly
lifting the epiglottis to view cords. With curved blade, place tip in
vallecula, elevate the epiglottis to visualize the vocal cords.
Preparation
Sedative
(see PART B)
Paralytic
A
NONE, OR
Severe
Lidocaine 1 mg/kg AND/OR
Fentanyl 2 mcg/kg OR
Etomidate 0.2–0.3 mg/kg**
Lidocaine 1 mg/kg
Status asthmaticus
Ketamine 1–2 mg/kg
B
FIGURE 1.1
A, Treatment algorithm for intubation. B, Sedation options. *No benefit of cricoid
pressure has been demonstrated. Do not continue if it interferes with ventilation or
speed of intubation. **Do not use routinely in patients with septic shock. (Modified
from Nichols DG, Yaster M, Lappe DG, et al., eds. Golden Hour: The Handbook of
Advanced Pediatric Life Support. St Louis: Mosby; 1996:29.)
Chapter 1 Emergency Management 7
TABLE 1.2
RAPID-SEQUENCE INTUBATION MEDICATIONS
1
Drug Dose Comments
ADJUNCTS (FIRST)
Atropine (vagolytic) 0.02 mg/kg IV/IO + Vagolytic; prevents bradycardia and
Adult dose: 0.5–1.0 mg; reduces oral secretions
max: 3 mg − Tachycardia, pupil dilation eliminates
ability to examine cardiovascular and
neurologic status (i.e., pupillary reflexes)
No minimum dose when using as
premedication for intubation
Indication: High risk of bradycardia (i.e.,
succinylcholine use)
Lidocaine (optional 1 mg/kg IV/IO; max + Blunts ICP spike, decreased gag/cough;
anesthetic) 100 mg/dose controls ventricular arrhythmias
Indication: Good premedication for shock,
arrhythmia, elevated ICP, and status
asthmaticus
SEDATIVE-HYPNOTIC (SECOND)
Thiopental 3–5 mg/kg IV/IO if + Decreases O2 consumption and cerebral
(barbiturate) normotensive blood flow
1–2 mg/kg IV/IO if − Vasodilation and myocardial depression;
hypotensive may increase oral secretions, cause
bronchospasm/laryngospasm (not to be
used for asthma)
Indication: Drug of choice for increased ICP
Ketamine (NMDA 1–2 mg/kg IV/IO or + Bronchodilation; catecholamine release
receptor 4–10 mg/kg IM may benefit hemodynamically unstable
antagonist) patients
− May increase BP, HR, and oral secretions;
may cause laryngospasm; contraindicated
in eye injuries; likely insignificant rise in
ICP
Indication: Drug of choice for asthma
Midazolam 0.05–0.1 mg/kg IV/IO + Amnestic and anticonvulsant properties
(benzodiazepine) Max total dose of − Respiratory depression/apnea,
10 mg hypotension, and myocardial depression
Indication: Mild shock
Fentanyl (opiate) 1–3 mcg/kg IV/IO + Fewest hemodynamic effects of all
NOTE: Fentanyl is dosed opiates
in mcg/kg, not mg/kg − Chest wall rigidity with high dose or rapid
administration; cannot use with MAOIs
Indication: Shock
Etomidate 0.2–0.3 mg/kg IV/IO + Cardiovascular neutral; decreases ICP
(imidazole/ − Exacerbates adrenal insufficiency by
hypnotic) inhibiting 11-beta-hydroxylase
Indication: Patients with severe shock,
especially cardiac patients. (Do not use
routinely in patients with septic shock)
Continued
8 Part I Pediatric Acute Care
TABLE 1.2
RAPID-SEQUENCE INTUBATION MEDICATIONS—cont’d
Drug Dose Comments
Propofol + Extremely quick onset and short duration;
2 mg/kg IV/IO
(sedative- blood pressure lowering; good antiemetic
hypnotic) − Hypotension and profound myocardial
depression; contraindicated in patients
with egg allergy
Indication: Induction agent for general
anesthesia
PARALYTICS (NEUROMUSCULAR BLOCKERS) (THIRD)
Succinylcholine 1–2 mg/kg IV/IO + Quick onset (30–60 s), short duration
(depolarizing) 2–4 mg/kg IM (3–6 min) make it an ideal paralytic
− Irreversible; bradycardia in <5 years old
or with rapid doses; increased risk of
malignant hyperthermia; contraindicated
in burns, massive trauma/muscle injury,
neuromuscular disease, myopathies, eye
injuries, renal insufficiency
Vecuronium 0.1 mg/kg IV/IO + Onset 70–120 s; cardiovascular neutral
(nondepolarizing) − Duration 30–90 min; must wait
30–45 min to reverse with glycopyrrolate
and neostigmine
Indication: When succinylcholine
contraindicated or when longer term
paralysis desired
Rocuronium 0.6–1.2 mg/kg IV/IO + Quicker onset (30–60 s), shorter acting
(nondepolarizing) than vecuronium; cardiovascular neutral
− Duration 30–60 min; may reverse in
30 min with glycopyrrolate and
neostigmine
+, Potential advantages; −, potential disadvantages or cautions; BP, blood pressure; HR, heart rate; ICP, intracranial
pressure; IM, intramuscular; IO, intraosseous infusion; IV, intravenous; MAOI, monoamine oxidase inhibitor; NMDA,
N-methyl-D-aspartate.
(7) If possible, have another person hand over the tube, maintaining
direct visualization, and pass through cords until black marker
reaches the level of the cords.
(8) Hold ETT firmly against the lip until tube is securely taped.
(9) Verify ETT placement: observe chest wall movement, auscultation
in both axillae and epigastrium, end-tidal CO2 detection (there
will be a false-negative response if there is no effective
pulmonary circulation), improvement in oxygen saturation, chest
radiograph, and repeat direct laryngoscopy to visualize ETT.
(10) If available, in-line continuous CO2 detection should be used.
(11) If patient is in cardiac arrest, continue chest compressions as
long as possible during intubation process to minimize
interruptions in compressions.
Chapter 1 Emergency Management 9
III. BREATHING2,7,8,18
A. Assessment
1
Once airway is secured, continually reevaluate ETT positioning (listen for
breath sounds). Acute respiratory failure may signify Displacement of the
ETT, Obstruction, Pneumothorax, or Equipment failure (DOPE).
B. Management
1. Mouth-to-mouth or mouth-to-nose breathing: provide two slow breaths
(1 sec/breath) initially. For newborns, apply one breath for every three
chest compressions. In infants and children, apply two breaths after
30 compressions (one rescuer) or two breaths after 15 compressions
(two rescuers). Breaths should have adequate volume to cause chest
rise.
2. Bag-mask ventilation is used at a rate of 20 breaths/min (30 breaths/
min in infants) using the E-C technique:
a. Use nondominant hand to create a C with thumb and index finger
over top of mask. Ensure a good seal, but do not push down on mask.
Hook remaining fingers around the mandible (not the soft tissues of
the neck), with the fifth finger on the angle creating an E, and lift the
mandible up toward the mask.
b. Assess chest expansion and breath sounds.
c. Decompress stomach with orogastric or NGT with prolonged bag-mask
ventilation.
3. Endotracheal intubation: See prior section.
V. RESPIRATORY EMERGENCIES21
The hallmark of upper airway obstruction is stridor, whereas lower airway
obstruction is characterized by cough, wheeze, and a prolonged expiratory
phase.
A. Asthma22-25
Lower airway obstruction resulting from triad of inflammation,
bronchospasm, and increased secretions:
1. Assessment: Respiratory rate (RR), work of breathing, O2 saturation,
heart rate (HR), peak expiratory flow, alertness, color.
2. Initial management:
a. Give O2 to keep saturation >95%.
b. Administer inhaled β-agonists: metered-dose inhaler or nebulized
albuterol as often as needed.
c. Ipratropium bromide.
d. Steroids:
(1) Severe illness: methylprednisolone, 2 mg/kg IV/IM bolus, then
2 mg/kg/day divided every 6 hours
(2) Mild-to-moderate illness: prednisone/prednisolone 2 mg/kg
(max 60 mg) PO every 24 hours for 5 days OR dexamethasone
0.6 mg/kg (max 16 mg) every 24 hours for 2 days
(3) Systemic steroids require a minimum of 2–4 hours to take
effect
Chapter 1 Emergency Management 11
1
(a) Bronchodilator, vasopressor, and inotropic effects
(b) Short acting (~15 min) and should be used as temporizing
rather than definitive therapy
(2) Terbutaline:
(a) 0.01 mg/kg SQ (maximum dose 0.4 mg) every 15 minutes for
up to three doses
(b) IV terbutaline—consider if no response to second dose of SQ
(see Further Management section for dosing)
(i) Limited by cardiac intolerance. Monitor continuous
12-lead electrocardiogram, cardiac enzymes, urinalysis
(UA), and electrolytes.
(c) Consider in severely ill patients or in patients who are
uncooperative with inhaled beta agonists
(3) Magnesium sulfate: 25 to 75 mg/kg/dose IV or IM (maximum
2 grams) infused over 20 minutes
(a) Smooth muscle relaxant; relieves bronchospasm
(b) Many clinicians advise giving a saline bolus prior to
administration, because hypotension may result
(c) Contraindicated if patient already has significant hypotension
or renal insufficiency
3. Further management: If incomplete or poor response, consider
obtaining an arterial blood gas value
NOTE: A normalizing PCO2 is often a sign of impending respiratory
failure.
a. Maximize and continue initial treatments.
b. Terbutaline 2 to 10 mcg/kg IV load, followed by continuous infusion of
0.1 to 0.4 mcg/kg/min titrated to effect in increments of 0.1 to
0.2 mcg/kg/min every 30 minutes depending on clinical response.
Infusion should be started with lowest possible dose; doses as high as
10 mcg/kg/min have been used. Use appropriate cardiac monitoring
in intensive care unit (ICU), as above.
c. A helium (≥70%) and oxygen mixture may be of some benefit in the
critically ill patient, but is more useful in upper airway edema. Avoid
use in the hypoxic patient.
d. Noninvasive positive-pressure ventilation (e.g., BiPAP) may be used in
patients with impending respiratory failure, both as a temporizing
measure and to avoid intubation, but requires a cooperative patient
with spontaneous respirations.
e. Methylxanthines (e.g., aminophylline) may be considered in the ICU
setting but have significant side effects and have not been shown to
affect intubation rates or length of hospital stay.
4. Intubation of those with acute asthma is potentially dangerous, and
should be reserved for impending respiratory arrest.
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TO CLEAR VEGETABLES FROM INSECTS.
Lay them for half an hour or more into a pan of strong brine, with
the stalk ends uppermost; this will destroy the small snails and other
insects which cluster in the leaves, and they will fall out and sink to
the bottom. A pound and a half of salt to the gallon of water will
answer for this purpose, and if strained daily it will last for some time.
TO BOIL VEGETABLES GREEN.
After they have been properly prepared and washed, throw them
into plenty of boiling water which has been salted and well skimmed;
and keep them uncovered and boiling fast until they are done, taking
every precaution against their being smoked. Should the water be
very hard, a small half-teaspoonful of carbonate of soda, may be
added with the salt, for every two quarts, and will greatly improve the
colour of the vegetables; but if used in undue proportion it will injure
them; green peas especially will be quickly reduced to a mash if
boiled with too large a quantity.
Water, 1 gallon; salt, 2 oz.; soda, 1/4 oz.; or carbonate of soda, 1
teaspoonful.
POTATOES.
104. We cannot refrain from a few words of remark here on the daily waste of
wholesome food in this country which constitutes one of the most serious
domestic abuses that exist amongst us; and one which it is most painful to
witness while we see at the same time the half-starvation of large masses of
our people. It is an evil which the steady and resolute opposition of the
educated classes would soon greatly check; and which ought not vainly to
appeal to their good sense and good feeling, augmenting, as it must, the
privations of the scantily-fed poor; for the “waste” of one part of the
community cannot fail to increase the “want” of the remainder.
TO BOIL POTATOES.
(As in Ireland.)
Potatoes, to boil well together, should be all of the same sort, and
as nearly equal in size as may be. Wash off the mould, and scrub
them very clean with a hard brush, but neither scoop nor apply a
knife to them in any way, even to clear the eyes.[105] Rinse them
well, and arrange them compactly in a saucepan, so that they may
not lie loose in the water, and that a small quantity may suffice to
cover them. Pour this in cold, and when it boils, throw in about a
large teaspoonful of salt to the quart, and simmer the potatoes until
they are nearly done, but for the last two or three minutes let them
boil rapidly. When they are tender quite through, which may be
known by probing them with a fork, pour all the water from them
immediately, lift the lid of the saucepan to allow the steam to escape,
and place them on a trivet, high over the fire, or by the side of it, until
the moisture has entirely evaporated; then peel, and send them to
table as quickly as possible, either in a hot napkin, or in a dish, of
which the cover is so placed that the steam can pass off. There
should be no delay in serving them after they are once taken from
the fire. Irish families always prefer them served in their skins. Some
kinds will be sufficiently boiled in twenty minutes, others in not less
than three quarters of an hour.
105. “Because,” in the words of our clever Irish correspondent, “the water through
these parts is then admitted into the very heart of the vegetable; and the
latent heat, after cooking, is not sufficient to throw it off; this renders the
potatoes very unwholesome.”
These are never good unless freshly dug. Take them of equal size,
and rub off the skins with a brush or a very coarse cloth, wash them
clean, and put them without salt into boiling, or at least, quite hot
water; boil them softly, and when they are tender enough to serve,
pour off the water entirely, strew some fine salt over them, give them
a shake, and let them stand by the fire in the saucepan for a minute;
then dish and serve them immediately. Some cooks throw in a small
slice of fresh butter, with the salt, and toss them gently in it after it is
dissolved. This is a good mode, but the more usual one is to send
melted butter to table with them, or to pour white sauce over them
when they are very young, and served early in the season.
Very small, 10 to 15 minutes: moderate sized, 15 to 20 minutes.
Obs.—We always, for our own eating, have new potatoes
steamed for ten minutes or longer after the water is poured from
them, and think they are much improved by the process. They
should be thoroughly boiled before this is done.
NEW POTATOES IN BUTTER.
Rub off the skins, wash the potatoes well and wipe them dry; put
them with three ounces of good butter, for a small dish, and with four
ounces or more for a large one, into a well-tinned stewpan or Keep
them well shaken or tossed, that they may be equally done, and
throw in some salt when they begin to stew. This is a good mode of
dressing them when they are very young and watery.
TO BOIL POTATOES.
108. Vegetables and fruit are now so generally forced and brought so early into
our markets, that there is little need of these expedients at present.
CRISPED POTATOES, OR POTATO-RIBBONS. (ENTREMETS.)
(A Plainer Receipt.)
After having washed them, wipe and pare some raw potatoes, cut
them in slices of equal thickness, or into thin shavings, and throw
them into plenty of boiling butter, or very pure clarified dripping. Fry
them of a fine light brown, and very crisp; lift them out with a
skimmer, drain them on a soft warm cloth, dish them very hot, and
sprinkle fine salt over them. This is an admirable way of dressing
potatoes, very common on the Continent, but less so in England
than it deserves to be. Pared in ribbons or shavings of equal width,
as in the receipt above, and served dry and well fried, lightly piled in
a dish, they make a handsome appearance, and are excellent
eating. If sliced they should be something less than a quarter of an
inch thick.
MASHED POTATOES.
Boil them perfectly tender quite through, pour off the water, and
steam them very dry by the directions already given in the receipt of
page 310, peel them quickly, take out every speck, and while they
are still hot, press the potatoes through an earthen cullender, or
bruise them to a smooth mash with a strong wooden fork or spoon,
but never pound them in a mortar, as that will reduce them to a close
heavy paste. Let them be entirely free from lumps, for nothing can be
more indicative of carelessness or want of skill on the part of the
cook, than mashed potatoes sent to table full of these. Melt in a
clean saucepan a slice of good butter with a few spoonsful of milk,
or, better still, of cream; put in the potatoes after having sprinkled
some fine salt upon them, and stir the whole over a gentle fire with a
wooden spoon, until the ingredients are well-mixed, and the whole is
very hot. It may then be served directly; or heaped high in a dish, left
rough on the surface, and browned before the fire; or it may be
pressed into a well buttered mould of handsome form, which has
been strewed with the finest bread-crumbs, and shaken free from the
loose ones, then turned out, and browned in a Dutch or common
oven. More or less liquid will be required to moisten sufficiently
potatoes of various kinds.
Potatoes mashed, 2 lbs.; salt, 1 teaspoonful; butter, 1 to 2 oz.; milk
or cream, 1/4 pint.
Obs.—Mashed potatoes are often moulded with a cup, and then
equally browned: any other shape will answer the purpose as well,
and many are of better appearance.
(Good.)
Boil some good potatoes as dry as possible, or let them be
prepared by Captain Kater’s receipt; mash a pound of them very
smoothly, and mix with them while they are still warm, two ounces of
fresh butter, a teaspoonful of salt, a little nutmeg, the beaten and
strained yolks of four eggs, and last of all the whites thoroughly
whisked. Mould the mixture with a teaspoon and drop it into a small
pan of boiling butter, or of very pure lard, and fry the boulettes for
five minutes over a moderate fire: they should be of a fine pale
brown, and very light. Drain them well and dish them on a hot
napkin.
Potatoes, 1 lb.; butter, 2 oz.; salt, 1 teaspoonful; eggs, 4: 5
minutes.
Obs.—These boulettes are exceeding light and delicate, and make
an excellent dish for the second course; but we think that a few
spoonsful of sweet fresh cream boiled with them until the mixture
becomes dry, would both enrich them and improve their flavour. They
should be dropped into the pan with the teaspoon, as they ought to
be small, and they will swell in the cooking.
POTATO RISSOLES.
(French.)
Mash and season the potatoes with salt, and white pepper or
cayenne, and mix with them plenty of minced parsley, and a small
quantity of green onions, or eschalots; add sufficient yolks of eggs to
bind the mixture together, roll it into small balls, and fry them in
plenty of lard or butter over a moderate fire, or they will be too much
browned before they are done through. Ham, or any other kind of
meat finely minced, may be substituted for the herbs, or added to
them.
POTATOES À LA MAÎTRE D’HÔTEL.
Boil in the usual manner some potatoes of a firm kind, peel, and
let them cool; then cut them equally into quarter-inch slices. Dissolve
in a very clean stewpan or saucepan from two to four ounces of
good butter, stir to it a small dessertspoonful of flour, and shake the
pan over the fire for two or three minutes; add by slow degrees a
small cupful of boiling water, some pepper, salt, and a tablespoonful
of minced parsley; put in the potatoes, and toss them gently over a
clear fire until they are quite hot, and the sauce adheres well to
them: at the instant of serving add a dessertspoonful of strained
lemon-juice. Pale veal gravy may be substituted for the water; and
the potatoes after being thickly sliced, may be quickly cut of the
same size with a small round cutter.
POTATOES À LA CRÈME.