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The bacterium is surrounded by a strong, rigid cell wall. The cell wall gives bacteria stiffness
and determines the form of the cell. It is a component of cell division. The cell wall also
offers a defence against osmotic damage to the cell.
The bacterial cell wall has lysozymes, bacteriophages, and antibiotic target sites. It transports
antigens from the bacteria that are vital to virulence and immunity.
Thin peptidoglycan layer – Peptidoglycan is a polymer of sugar and amino acids and is often
single-layered in the gram-negative cell wall.
Outer membrane – It is a protein layer that acts as a target site for antibiotics and phages.
Lipoprotein layer – Links the peptidoglycan to the outer cell membrane.
Lipopolysaccharide – It constitutes the endotoxicity of gram-negative bacteria. The toxicity is
associated with the lipid A molecule of the lipopolysaccharide.
Periplasmic space – It is the space between the outer and inner membranes.
It lacks an outer membrane and lipopolysaccharide but has other components such as
polysaccharides and proteins.
Explore: Difference between Gram-positive and Negative Cell Wall
1. L-forms – It is a growth form of bacteria that has no cell wall. Murein or peptidoglycan is absent.
L-forms develop when agents like penicillin interfere with the formation of cell walls.
2. Mycoplasma – They are naturally occurring bacteria that lack a cell wall. These are classified
under an independent genus.
3. Spheroplasts – It is a bacterial cell whose cell wall has been nearly or totally destroyed due to the
actions of lysozyme or penicillin. It is usually derived from gram-negative bacteria.
4. Protoplasts – The term refers to the whole cell, excluding the cell wall. Spheroplasts and
protoplasts are different from one another as in the latter, the cell wall has been entirely removed.
It is usually derived from gram-positive bacteria.
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