A Project Work

INVESTIGATION OF NOVEL DRUG TARGETS: EXPLORING AND

VALIDATING MOLUCULAR TARGETS FOR DRUG DEVELOPMENT

Submitted to

Maharishi School of Pharmaceutical Sciences

In the Requirement of Degree

BACHELOR OF PHARMACY

Submitted By

MANSI DIXIT

Enrollment No. MUIT0120058039

Roll No. 2001058128047

Under the Supervision of

Mr. Shubham Bhatt

Assistant Professor

Maharshi School of Pharmaceutical Sciences, Maharishi University of

Information Technology, Lucknow

Session – 2023-2024

I
 DECLARATION BY THIS CANDIDATE

I hereby declare that the matter embodied in the dissertation entitled

“INVESTIGATION OF NOVEL DRUG TARGETS: EXPLORING AND
VAILDATING MOLUCULAR TARGETS FOR DRUG DEVELOPMENT” a
bonafied and genuine research work carried out by me under the guidance of
Mr. Shubham Bhatt Department Maharishi School of Pharmaceutical
Sciences, MUIT. The work embodied in this project is original and has not
been submitted as the basis for award for degree for University.

Name of Students: MANSI DIXIT

Date:

Place: Maharishi School of Pharmaceutical Sciences, MUIT Lucknow

II
 CERTIFICATE

Certified that MANSI DIXIT(2001058128059) has carried out the research

work presented in this project work entitled INVESTIGATION OF NOVEL
DRUG TARGETS: EXPLORING AND VALIDATING MOLECULAR
TARGETS FOR DRUG DEVELOPMENT for the award of Bachelor of
Pharmacy from Maharishi School of Pharmaceutical Sciences, MUIT
Lucknow under the supervision of Mr. Shubham Bhatt The project work
embodies result of original work, and studies are carried out by the students
himself and the content of the project work do not form award of any other
degree to the candidate or to anybody else from this of any other University /
Institution.

Mr. Shubham Bhatt Dr. Shikhar

Verma

(Assistant Professor) Dean of MSOPS,

Lucknow

III
 ENDORSMENT BY THE DEAN/ HEAD OF THIS INSTITUTION

This is to certify that the dissertation work entitled “INVESTIGATION OF

NOVEL DRUG TARGETS: EXPLORING AND VALIDATING
MOLECULAR TARGETS FOR DRUG DEVELOPMENT” Submitted in
partial fulfillment of the requirement for the degree of Bachelor of Pharmacy of
Maharshi School of Pharmaceutical Sciences, MUIT Lucknow is a bonafied
work carried out by MANSI DIXIT under the genial guidance and supervision
of Mr. Shubham Bhatt

Date: Dr. Shikhar Verma

Dean of MSOPS, Lucknow

IV
 Table and Content

Sr. No Content Page No.

1. DECLRATION BY THIS I
CANDIDATE
2. CERTIFICATE II
3. ENDORSEMENT BY THE DEAN III
OF THE INSTITUTE
4. ABSTRACT V
5. ACKNOLEDGEMENT VI
6. INTRODUCTION 1-5
7. AIM&OBJECTIVE 6
8. METHODOLOGY 7-8
9. RESULT&CONCLUSION 9
10. REFRENCE 10-14

V
 INVESTIGATION OF NOVEL DRUG TARGETS: EXPLORING AND
VALIDATING MOLECULAR TARGETS FOR DRUG DEVELOMENT

Maharshi School of Pharmaceutical Sciences

Mansi Dixit, Shubham Bhatt

Author’s Address- manshidixit2266@gmail.com

ABSTRACT –
The key to diagnosing hypertension in both children and adults involves first accurately
measuring the blood pressure and then accurately interpreting the obtained results. In
the pursuit of understanding the importance of this measurement and over the course of
centuries and countless experiments, first invasive (using arterial lines) and then refined
noninvasive methods for measuring blood pressure were developed. In a contemporary
clinical outpatient setting, unless a research study requires patients to have their blood
pressure measured according to a specific procedure, a sphygmomanometer is applied
to a patient when he or she is at rest; this is referred to as “casual or office blood
pressure.” In the following chapter, we will review current methods employed to
measure casual blood pressure and identify their advantages, disadvantages, and
pitfalls. The physiologic response to exercise may provide valuable prognostic
information. We investigated the association of blood pressure (BP) measurements
during exercise stress testing (EST) with long-term risk of myocardial infarction, stroke
or death (major adverse cardiovascular event, MACE), as well as the development of
new-onset hypertension. To test if the prognostic value of dipping status is driven by
nighttime systolic blood pressure (BP) level.

KEYWORD- Hypertension, Angiotensin Receptor, Drug Targets, Drug Targets, Drug

Discovery, Aldosterone Receptor, Blood Pressure, etc

VI
 ACKNOWLEDGEMENT
During the Project work, I was accompanied and supported by many people. It is an
exceptional aspect that I know the probability of my gratitude for all of them. With sincerity,
I specifically my heartfelt gratitude to my revered Dean Prof (Dr.) Shikhar Verma and
Deputy Dean Mr. Prakash Deep.
I consider myself fortunate to work under the supervision of Mr. Shubham Bhatt (Assistant
Professor). It is due to the fact his precious intellectual guidance, innovative ideas, and given
me whole independence, and affectionate encouragement to put my wish and concept paved
the way for the profitable completion of this work. Working beneath to put him is
remarkable.

I categorical my unique regards to my respected teachers like Ms. Deepika Gupta and Mr.
Vipin Kesharwani for their guidance, and optimistic ideas and for having given me whole
independence, and affectionate encouragement to put wish and thought.

I take this opportunity to thank my friends, OMENDRA PRATAP SINGH, MANSI

DIXIT, GOPESHWAR GUPTA for their editing help and moral support.

Without the support encouragement and love of my Family. I would have never been the
whole I am. I desire there were higher words than indebtedness gratitude, to express my
emotions towards them. I am incomplete except for my family.

Last but not least. I praise the almighty who instilled my confidence, persistence, and
association willpower to satisfy my dreams.

MANSI DIXIT
Date:
Place: MSOPS, MUIT Lucknow

VII