Mengapa kolesterol

harus diobati?
 KERUSAKAN APA SAJA YANG BISA DISEBABKAN
OLEH PLAQUE?
Stroke

Coronary artery
• Plaque rupture
→ unstable angina Pulmonary embolism
→ Myocardial infarction (PE)
(MI) / heart attack

Deep vein
thrombosis (DVT)
 The Cardiovascular Continuum of Events
ACS
Coronary
Secondary Arrhythmia and
Thrombosis Stroke Loss of
prevention Muscle
Myocardial Remodeling
Ischemia

Ventricular
PJK Dilatation

Atherosclerosis Congestive
Heart Failure
Primary
prevention Risk Factors End-stage
( Dyslipidemia, ↑ BP, DM, Heart Disease
Insulin Resistance, Platelets,
Adapted from
Fibrinogen, etc)
Dzau et al. Am Heart J. 1991;121:1244-1263
 Atherosclerosis: Penyakit Sistemik

From a prospective analysis of 1886 patients aged ≥62 years, 810 patients were diagnosed with CAD as
defined by a documented clinical history of MI, ECG evidence of Q-wave MI, or typical angina without
pArroenvoiwouWsSMetIa.,l(AAmdaJpCtaerddo i flr,o1m994A.ronow et al.)
 Hubungan Kolesterol Dan
Stroke
MRFIT: Angka kematian akibat stroke selama 6 th (n=350,977)
8
Subarachnoid hemorrhage
deathratio

Intracranial
6
hemorrhage

Non-hemorrhagic
4

2
adjusted

0
Age

< 160 160-199 200-239 240-279 >280

Serum

cholesterol
 Bahaya kolesterol yang tidak terkontrol

Plaque akibat kolesterol yang tidak

terkontrol menyebabkan:
●
Penyempitan pembuluh darah
●
Aliran darah ke jantung dan otak
terganggu
●
Menyebabkan SERANGAN JANTUNG,
STROKE, dan KEMATIAN MENDADAK