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PDF Understanding Research Methods For Evidence Based Practice in Health 2Nd Edition Trisha M Greenhalgh Ebook Full Chapter
PDF Understanding Research Methods For Evidence Based Practice in Health 2Nd Edition Trisha M Greenhalgh Ebook Full Chapter
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BRIEF CONTENTS
About the authors vii
Index 133
CONTENTS
About the authors vii 3.2 Reviewing the methods of primary
research papers 25
CHAPTER 1 Sample and setting: who are the participants,
and where is the study being
Introduction to research, the carried out? 25
research process and EBP 1 What data-collection methods
1.1 The meaning of ‘evidence-based were used? 26
practice’ 2 How was the data analysed? 26
1.2 Apprehension towards evidence-based 3.3 Reviewing the methods of secondary
practice 5 (review) papers 26
Decision making by anecdote 6 Question 1. What is the focused clinical
Decision making by press cutting 6 question that the review addressed? 27
Decision making by expert opinion 6 Question 2. Was a thorough search of the
Decision making by cost minimisation 7 appropriate database(s) carried out, and
were other potentially important
1.3 Before you start: formulate the problem 8
sources explored? 27
CHAPTER 2 Question 3. Who evaluated the studies,
and how? 28
Asking questions and Question 4. How sensitive are the results
to the way the review has
searching for evidence 11 been performed? 28
2.1 Different types of searching Question 5. Have the results been interpreted
for evidence 12 sensibly, and are they relevant to the
Informal 12 broader aspects of the problem? 28
Focused looking for answers 13 Meta-analyses and meta-syntheses 28
Searching the literature 13
2.2 Differences between primary and CHAPTER 4
secondary research 13
2.3 Effective search strings 13
Qualitative research 32
Steps for effective searching 14 4.1 Qualitative research explained 33
One-stop shopping: federated 4.2 The difference between qualitative and
search engines 16 quantitative research 34
2.4 Other avenues for how to search 4.3 Qualitative methodologies and data
for evidence 17 collection strategies 35
Searching for information using Qualitative sampling 36
social media 19 Data collection 36
4.4 Evaluating papers that describe
CHAPTER 3 qualitative research 37
Question 1. Did the paper describe an
Reviewing literature 21 important clinical problem addressed via a
3.1 Is a paper worth reading at all? 23 clearly formulated question? 38
Question 1. Who wrote the paper? 23 Question 2. Was a qualitative approach
Question 2. Is the title appropriate appropriate? 38
and illustrative, and is the Question 3. How were (a) the setting and
abstract informative? 23 (b) the subjects selected? 38
Question 3. What was the research design, Question 4. What was the researcher’s
and was it appropriate to the perspective, and has this been taken
question? 24 into account? 38
Question 4. What was the research question, Question 5. What methods did the researcher
and why was the study needed? 24 use for collecting data, and are these
Question 5. Do the results or findings answer described in enough detail? 39
the question? 24
Question 6. What methods did the researcher Have valid assumptions been made about the
use to analyse the data, and what quality nature and direction of causality? 78
control measures were implemented? 39 7.4 Probability and confidence 79
Question 7. Are the results credible and, if so, How are p values interpreted? 79
are they clinically important? 40 Confidence intervals 81
Question 8. What conclusions were drawn, 7.5 Clinical importance of treatment
and are they justified by the results? 40 effects 81
Question 9. Are the findings of the study Clinical importance 81
transferable to other settings? 40 7.6 Summarising treatment effects from
multiple studies of interventions in a
CHAPTER 5
systematic review 84
Quantitative research 43
CHAPTER 8
5.1 Why and how quantitative research
is done 44 Mixed methods research 88
5.2 Quantitative research designs 46 8.1 An overview of mixed methods
Intervention studies 46 research 89
Observational studies 47 Why use mixed methods in nursing and health
5.3 Measurement 48 sciences research? 89
Variables — independent 8.2 Different mixed methods designs 90
and dependent 49 Convergent study 90
Reliability and validity in measurement 50 Sequential study 91
Multiphase (multilevel) study 91
CHAPTER 6
Embedded study 92
Levels of evidence 55 8.3 Integration in mixed methods
6.1 Clinical questions in healthcare 56 research 93
Finding the best evidence 56 Integrating the research question 93
NHMRC and evidence-based practice 57 Research design 93
How researchers answer Sampling 93
clinical questions 57 Analysis 93
6.2 Matching clinical questions to NHMRC Interpretation 94
levels of evidence 58 8.4 Mixed method design considerations 94
NHMRC evidence levels for Weighting (dominance) 94
intervention studies 60 General challenges associated with mixed
6.3 How bias threatens the validity of research methods studies 94
evidence 63
CHAPTER 9
6.4 Evaluating the evidence – quality of
evidence and grades of recommendations Sampling 97
for practice guidelines 65
9.1 Understanding the terminology around
6.5 Levels within levels 66
sampling 98
Theoretical population (or target
CHAPTER 7
population) 98
Statistics for the Study population (or accessible
population) 98
non-statistician 73 Sampling 99
7.1 Storing quantitative data in a data set 74 Sample 99
7.2 Descriptive statistics for summarising Sampling frame 99
sample characteristics 75 9.2 Types of sampling 99
Descriptive statistics for Probability sampling 99
categorical variables 75
Non-probability sampling 100
Descriptive statistics for
Sampling methods 100
continuous variables 76
9.3 Sampling error 102
7.3 The researchers ‘setting the scene’ 77
9.4 Calculating sample size 102
Have the researchers tested the assumption
Quantitative research 102
that their groups are comparable? 77
Qualitative research 103
What assumptions apply to the shape
of the data? 77
CONTENTS v
CHAPTER 10 11.3 Organisational support of evidence-
based practice 117
Ethics 106 Integrated care pathways 117
10.1 Ethical principles 107 Clinical practice guidelines 118
Autonomy: patients/clients are free to 11.4 The client perspective in evidence-
determine their own actions 107 based practice 119
Beneficence: acting to benefit Patient-reported outcome measures
human kind 108 (PROMs) 119
Justice: obligation to treat fairly 108 Shared decision-making 119
Non-maleficence: avoiding or minimising Option grids 120
harm 108
Respect for human dignity 108 CHAPTER 12
Confidentiality: maintenance of privileged
information, including the right to privacy Challenges to evidence-
and anonymity 109 based practice 124
Veracity: obligation to tell the truth 109 12.1 When evidence-based practice is
10.2 The role and function of human research done badly 126
ethics committees 109 12.2 When evidence-based practice is
10.3 Judging the ethical aspects of a done well 126
published journal article 111 Guidelines devalue
professional expertise 126
CHAPTER 11
The guidelines are too narrow (or
Getting evidence into too broad) 127
The guidelines are out of date 127
practice 114 The client’s perspective is ignored 127
11.1 Adoption of evidence-based There are too many guidelines 128
practice (EBP) 115 Practical and logistical problems 128
Individual barriers 115 The evidence is confusing 128
Organisational barriers 116 12.3 Achieving evidence-based practice 129
11.2 Encouraging individuals to implement
evidence-based practice 116 Index 133
vi CONTENTS
ABOUT THE AUTHORS
Trisha M Greenhalgh
Dr Trisha Greenhalgh is a Professor of Primary Care Health Sciences at the University of Oxford and
a practising GP. She completed a BA in Social and Political Sciences at the University of Cambridge
in 1980 and a medical degree at the University of Oxford in 1983. Trisha’s research aims to apply the
traditional aspects of medicine while embracing the opportunities of contemporary science to improve
health outcomes for patients. She is the author of more than 240 peer-reviewed publications as well as
a number of scholarly textbooks. Trisha has received numerous accolades for her work, including twice
winning the Royal College of General Practitioners Research Paper of the Year Award, and receiving the
Baxter Award from the European Health Management Association. In 2001, she was awarded an OBE for
services to evidence-based medical care.
John Bidewell
Dr John Bidewell is a Lecturer in Research Methods at the School of Science and Health at Western
Sydney University. From an early career in school teaching, John moved into psychology, acquiring three
degrees while always maintaining an interest in education. Opportunities arose in applied social research
and data analysis, leading John in that direction. For many years, he provided technical and inspirational
support to academic and student researchers, covering every stage of the research process from concept to
publication, and especially data analysis and interpretation, at Western Sydney University’s nursing and
midwifery school. John has provided consultancy services in research and statistics to business, industry
and governments, and has taught research methods and statistics to nursing, business and allied health
students at undergraduate and postgraduate levels.
Elaine Crisp
Dr Elaine Crisp is a Registered Nurse (RN) and Lecturer at the School of Nursing at the University
of Tasmania, where she coordinates both the Bachelor of Nursing (BN) course and the Translational
Research unit within the BN. This dual role enables her to ensure the BN highlights the connection between
research and clinical practice. She has also taught research methods to nursing and allied health students
at the postgraduate level, encouraging clinicians to understand and use research evidence in their everyday
practice. Elaine worked as an RN in aged care and in the perioperative area before commencing her PhD,
which combined her love of history and nursing. Her major research interests are nursing and welfare
history, aged and dementia care, and nurse education.
Amanda Lambros
Amanda E Lambros is a Professional Speaker, Author and Clinical Counsellor as well as a past Clinical
Fellow. She has completed a Bachelor of Health Sciences at the University of Western Ontario (2001), a
Postgraduate Diploma of Ethics (2002), a Master of Forensic Sexology (2004) and a Master of Counselling
(2014). Amanda has developed, coordinated and taught evidence-informed health practice to thousands of
Interprofessional First Year Health Sciences students throughout her career. Amanda’s private practice
focuses on relationships, mental health, and grief and loss. Providing her clients with the most up-to-date
and evidence-based care is imperative to her, and she has a strong focus on EBP, ethics and communication.
Amanda has received numerous accolades for her work, including NifNex 100 Most Influential Business
Owners, a Telstra Business Award nomination and a Telstra Business Woman of the Year nomination.
Jane Warland
Dr Jane Warland is an Associate Professor at the School of Nursing and Midwifery at the University
of South Australia (UniSA). She worked as a midwife from 1988 to 2007, and gained her PhD from
the University of Adelaide in 2007. Jane was appointed as an academic staff member to the School of
Nursing and Midwifery in February 2008, and teaches a foundational research course in the undergraduate
midwifery program. Her own program of research is STELLAR (stillbirth, teaching, epidemiology, loss,
learning, awareness and risks). Jane has a track record in research using qualitative, quantitative and mixed
methods. She has a strong interest in research ethics and served two terms as a member of the UniSA
Human Research Ethics Committee. Jane has written numerous book chapters about research — she has
more than 90 publications, including books, chapters and peer-reviewed journal articles.
CHAPTER 1
Introduction to research,
the research process
and EBP
LEARNING OBJECTIVES
Students regularly allow the idea of ‘numbers’ and a ‘new language’ to blur their excitement for learning
about EBP — please don’t let this happen to you. Be open to learning about the topic, which will stick
with you for the rest of your life. The more open you are to learning about EBP, the better the practitioner
you will become!
The second reason that people often groan when you mention evidence-based practice is because there
are plenty of daunting new (and often long) words that look like a foreign language. While it is like a
new language, absolutely everything in EBP can be broken down into simple and manageable steps. For
example, students are often stumped by retrospective longitudinal cohort design (which you will learn
about in this resource), but once they break it down, it makes perfect sense:
• retrospective — in the past (think of the word ‘retro’)
• longitudinal — over a long period of time
• cohort — a group of people
• design — type of study.
Now that it’s broken down into manageable chunks, you instantly know that ‘retrospective longitudinal
cohort design’ means a type of study that was done over a long period, looking at a group of people in
the past. So, please don’t feel overwhelmed by the words — they all make sense, but some just need to be
broken down first.
Anyone who works face-to-face with clients knows that it is necessary to seek new information before
making a clinical decision. Health practitioners spend countless hours searching through libraries, books
and online to inform their practices. In general, we wouldn’t put a client on a new drug or through a
new treatment without evidence that it is likely to work — but, unfortunately, best practice is not always
followed. There have been a number of surveys on the behaviours of health professionals. In the United
States in the 1970s, only around 10–20 per cent of all health technologies then available (i.e. drugs,
procedures, operations, etc.) were evidence-based; in the 1990s, that figure improved to 21 per cent.8
Studies of the interventions offered to consecutive series of clients suggested that 60–90 per cent of clinical
decisions, depending on the specialty, were ‘evidence-based’.9 Unfortunately, due to various excuses and
limitations, we are still selling our clients short most of the time.
A large survey by an Australian team looked at 1000 clients treated for the 22 most commonly seen
conditions in a primary-care setting. The researchers found that while 90 per cent of clients received
evidence-based care for coronary heart disease, only 13 per cent did so for alcohol dependence.10
Furthermore, the extent to which any individual practitioner provided evidence-based care varied in the
sample from 32 per cent of the time to 86 per cent of the time. A more recent study found that one in
three hospitals are not meeting performance metrics. One of the leading reasons was failure to implement
EBP.11 Following this, a study suggested that medical error is now the third leading cause of death in the
United States.12 These findings suggest plenty of room for improvement; therefore, with a new wave of
practitioners, hopefully we can increase the application of EBP so that the majority of health consumers
are receiving evidence-based care.
Let’s look at the various approaches that many health professionals use to reach their decisions in
reality — all of which are examples of what EBP isn’t . . . therefore, please do not practise these!
Early 1900s Complete immobilisation in the 1930s Although very hot dressings
form of splints and braces on and physical therapy (what we
the affected limbs for infantile now know as physiotherapy)
paralysis (Polio) was deemed to be effective,
it was not fully implemented
for the treatment of polio until
the 1950s
From at least 1900 Bed rest for acute low 1986 Many doctors still advise people
back pain with back pain to ‘rest up’
Late 1990s Cox-2 inhibitors (a new class of 2004 Cox-2 inhibitors for pain were
non-steroidal anti-inflammatory quickly withdrawn following
drug), introduced for the some high-profile legal cases
treatment of arthritis, were later in the United States, although
shown to increase the risk of new uses for cancer treatment
heart attack and stroke (where risks may be outweighed
by benefits) are now being
explored
a
Interestingly, bloodletting was probably the first practice for which a randomised controlled trial was suggested.
KEY TERMS
evidence-based care Care that is based on evidence-based practice (supported by scientific evidence,
clinical expertise and client values).
evidence-based practice (EBP) A practice that is supported by scientific evidence, clinical expertise
and client values.
knowledge An accepted body of facts or ideas that is acquired through the use of the senses, reasons
or through research methods.
retrospective longitudinal cohort design A type of study conducted over a long period, looking at a
group of people in the past.
WEBSITES
1 Centre for Research in Evidence-based Practice (CREBP): https://bond.edu.au/researchers/research-
strengths/university-research-centres/centre-research-evidence-based-practice
2 Centre for Evidence-based Medicine: www.cebm.net
3 ‘What is evidence-based medicine?’, British Medical Journal: www.bmj.com/content/312/7023/71
4 HPNA Position statements ‘Evidence-Based Practice’, Hospice and Palliative Nurses Association
(US): https://advancingexpertcare.org/position-statements
5 Joanna Briggs Institute: www.joannabriggs.org
6 Australasian Cochrane Centre: http://aus.cochrane.org
7 ‘Evidence-based information’, QUT Library: www.library.qut.edu.au/search/howtofind/evidencebased
8 ‘Answering Clinical Questions’, University of Western Australia: www.meddent.uwa.edu.au/
teaching/acq
9 ‘Evidence based practice’, University of Tasmania: https://utas.libguides.com/ebp
10 ‘Introduction to evidence-based practice’, Duke University Medical Center Library and the Health
Sciences Library at the University of North Carolina: https://guides.mclibrary.duke.edu/ebmtutorial
ENDNOTES
1. M. Hurley et al., ‘Hip and knee osteoarthritis: a mixed methods review,’ Cochrane Database of Systematic Reviews 4 (2018).
doi:10.1002/14651858.CD010842.pub2.
2. D. L. Sackett et al., ‘Evidence-based practice: what it is and what it isn’t,’ BMJ: British Medical Journal 312, no. 7023
(1996): 71.
3. Sackett, ‘Evidence-based practice,’ 71.
4. K. Head et al., ‘Saline irrigation for allergic rhinitis,’ Cochrane Database of Systematic Reviews 6 (2018).
doi:10.1002/14651858.CD012597.pub2.
5. D. L. Sackett and R. B. Haynes, ‘On the need for evidence-based practice,’ Evidence-based Practice 1, no. 1 (1995): 4–5.
6. T. Greenhalgh, ‘Is my practice evidence-based?,’ BMJ: British Medical Journal 313, no. 7063 (1996): 957.
7. T. Greenhalgh, How to read a paper: the basics of evidence-based medicine (Oxford: Blackwell-Wiley, 2006).
8. M. Dubinsky and J. H. Ferguson, ‘Analysis of the national institutes of health medicare coverage assessment,’ International
Journal of Technology Assessment in Health Care 6, no. 3 (1990): 480–8.
9. D. L. Sackett et al., ‘Inpatient general practice is evidence-based,’ The Lancet 346, no. 8972 (1995): 407–10.
ACKNOWLEDGEMENTS
Adapting author for this Australian edition: Amanda Lambros
Photo: © Halfpoint / Shutterstock.com
2.1 What are the different reasons we might search for evidence?
2.2 What are the differences between primary research and secondary literature?
2.3 How do you construct an effective search string?
2.4 What are some other avenues for how to search for evidence?
Focused looking for answers
Focused looking for answers should take a much more detailed approach, especially if we can trust the
‘answer’ we find and apply it directly to the care of a client. When we find information, we need to know
how we can tell if it is trustworthy and, if so, that it is OK to stop looking — we don’t need to find
absolutely every study that may have addressed this topic. This kind of query is increasingly well served
by new synthesised information sources whose goal is to support evidence-based care and the transfer of
research findings into practice. This is discussed in more detail shortly.
Information
retrieval, Data
Professional Collaboration filtering collection Dissemination
Example profile and and project and and and
Activity tools networking management management storage translation
Cloud Google ✓ ✓ ✓
services Docs
(software)
Cloud Dropbox, ✓ ✓
storage Google Drive,
MS Office 365
Reference Mendeley, ✓ ✓ ✓
managers Zotero,
Endnote web,
CiteULike
Clinical ✓ ✓
databases
and
registries
Survey SurveyMonkey, ✓ ✓
tools Qualtrics,
Poll Daddy,
Google Forms
Mobile Text ✓ ✓
devices messaging,
apps
Social Facebook, ✓ ✓ ✓
networking Twitter,
Yammer
Blogging WordPress, ✓ ✓ ✓
Blogger
Microblogging Twitter, ✓ ✓ ✓ ✓
Instagram,
TweetDeck,
Tumblr
Curation Scoop.it, ✓ ✓
Pinterest
Video YouTube, ✓ ✓ ✓
hosting Vimeo
Altmetrics Impactstory.org, ✓ ✓
altmetrics.com
KEY TERMS
advanced search Allows you to set specific parameters for your results, such as year, author, title or
study type. This option usually means you have less hits that are more relevant than results from a
basic search.
Boolean operators The use of AND, OR and NOT to expand or exclude keywords in a search, which
then results in more focused or productive search results.
primary research An original piece of research from a single study.
search string A list of words or phrases, which when combined are used to search for a specific piece of
information contained in a database.
secondary research Research that has examined multiple primary research papers and summarised
them.
truncation A searching technique used when searching databases in which a word ending is replaced by
a symbol — an asterisk (*), a question mark (?) or a dollar sign ($) — to enable the search to include
all possible endings of the word.
wildcards A searching technique used when searching databases in which a letter in a word is replaced
by a symbol — an asterisk (*), a question mark (?) or a dollar sign ($) — to enable the search to
include alternate spellings of the word.
WEBSITES
1 ‘Finding the evidence’ from the University of Oxford’s Centre for Evidence-Based Medicine includes
a series of helpful resources, including videos on searching databases: www.cebm.net/category/ebm-
resources/tools/finding-the-evidence
2 ‘PubMed tutorial’ from PubMed offers an overview of what PubMed does and doesn’t do, as well as
some exercises to help you get used to how to use it: www.nlm.nih.gov/bsd/disted/pubmedtutorial/cover.html
ENDNOTE
1. A. Hoogendam et al., ‘Answers to questions posed during daily patient care are more likely to be answered by UpToDate than
PubMed,’ Journal of Medical Internet Research 10, no. 4 (2008): e29.
ACKNOWLEDGEMENTS
Adapting author for this Australian edition: Jane Warland
Photo: © Twin Design / Shutterstock.com
Photo: © nopporn / Shutterstock.com
Figures 2.1, 2.2 and 2.3: © PubMed / Public Domain
Figure 2.4: © Trip Database
Table 2.1: Reprinted with permission of John Wiley & Sons, Inc.
Reviewing literature
LEARNING OBJECTIVES
Moisture
On The Corning Egg Farm moisture is provided in the Cellar by
thoroughly wetting the floor with a hose twice a day, the floor sloping
gently to a drain in one corner. Large earthen-ware vessels, of about
three inches in depth and eighteen inches in diameter, are stood at
different points throughout the Cellar, and are constantly kept filled
with fresh water. This is done, not so much for the purpose of
increasing the humidity of the air, as it is to take up the impurities. As
an illustration, if you stand vessels filled with water in a freshly
painted room, the odor of paint is almost entirely absorbed by the
water.
As even a temperature as possible is carried in the Cellar, and at
all times there is a constant flow of fresh air, but it is so controlled
that it does not produce a draught. It should be remembered that
while a moist cellar is desirable, unless it is well ventilated, it is
utterly unfit for the purpose of incubation.
Eggs Chicks
Clear
Dead on 191
——— ———
Hatchable Moved to
Colony House No.
Chicks
Turn P. M.
14th day
18th day
21st day
A Balanced Food
On The Corning Egg Farm the question of chick food that could
properly be called “chick food” has been a study for years, the
problem being to procure a balanced ration containing, as closely as
possible, the ingredients intended by Nature for a young chick to eat
and thrive on. Many experiments were made with different mixtures,
both with chicks running with natural mothers and with those being
reared in the Brooder House, and it was found that in all cases
where corn was fed in the mixture the results were bad. The
youngsters running with the hen did not show the large mortality
which those did in the Brooder House, but even the broods running
with the hen did not do nearly so well where the corn was fed, as did
those not having this ingredient in their food.
The great mortality in young chicks is produced by the upsetting of
their digestive organs. Corn is very heating, and as soon as the
chick’s blood is over-heated its digestive organs fail to work properly,
and what is now known as “White Diarrhœa” almost invariably
develops. It is claimed by some authorities that this difficulty comes
from a germ which is in the egg before incubation. This may be the
case, but it is certainly true that wrong feeding will bring this germ
into active life, and snuff out the existence of the chick.
Another phase, which has been a special study on The Corning
Egg Farm in the brooding of chicks, is an abundant supply of fresh
air, not only in the room itself, but also to have the oxygen fed to the
chicks properly when they are under the hovers. The use of gas for
heating the hovers was found a decided improvement over the lamp,
so far as the freshness of the air went, but, for procuring the purest
hot air, to flow up into the hovers, we are now installing a system of
hot water pipes.