(HPERSENSITIVITY)

PRRVS

94940 90037

10%

??

ALLERGINS

- Pencillin,Aspirin etc.
Airborne particles - Pollen grains, House
dust mite, Spores etc.
, , .
Bacteria,Fungi,
Parasites etc.

DUST MITE




ARE THEY ...............................

...

TEMPTING ??

( IMMEDIATE
HYPERSENSITIVITY)

(DELAYED
HYPERSENSTIVITY)



Immediate Hypersensitivity

..


,


B

Ag Ab

Seerum


; antihistamines



(Delayed Hypersensitivity)

24-48
Ag T-

Corticosteroids

COMB & GEL Classification

Type I- Classical immediate hypersensitivity
(or) Anaphylaxis reaction.
Type II-

(Cytotoxic hypersensitivity)
Type III-




(Immune Complex mediated hypersensitivity.)
Type IV

(Delayed hypersensitivity)

Type I Hypersensitivity
Anaphylaxis

,

hay fever,
, ,
,
asphyxia

Anaphylaxis

B. Mast Cell
Target organs

ANAPHYLAXIS

Lungs
Heart
Vasculature
Cutaneous

Cardiovascular
collapse
Urticaria
Bronchospasm

Mediators of Anaphylaxis
Primary
: Histamines, Heparin,
Serotonin
Secondary

: Prostaglandins, Leukoproteins,
Platelet Activating Factor

Treatment

Atopic dermatitis
neurodermatitis
- (allergy - related)
:, ,




(Type II Hypersensitivity)

Ig G / Ig M

Surface bound Ags & Abs

Complement activated Phagocytosis &
Cell lysis
1.
(Iso immune reactions)
2.
(Autoimmune
Reactions)



(ISOIMMUNE REACTIONS)
Ag Ab

:
1.ABO blood transfusion reactions
2. Rh factor Erythroblastosis
foetalis
3.Haemolytic anaemia

Erythroblastosis foetalis



(Autoimmune reactions)

(Auto antigens)

(Auto antibodies)
Eg: 1.Autoimmune Hemolytic Anemia
2. Thrombocytopaenia
3.Thyroiditis
4. Glomerulonephritis



..
..

Type III:

( Immune Complex Mediated Hypersenitivity)

Immune complex mediated

IgG or Ig M involved
Eg: Arthus Reaction
Serum sickness

ARTHUS REACTION

Arthus

IgE
Erythma, oedema, induration,
hamorrhages .

SERUM SICKNESS

..
Immune complexes

glomeruli
,

Type III

Complex size
Antigen exposure duration
Host response
Local tissue factors

Type IV

(DELAYED HYPERSENSITIVITY)

Ag sensitized T cells
Ab

24-72
T lymphokines
macrophages

Tuberculin mantoux


?????


..........