100s of free ppts from

www.pptpoint.com library

actin

actin

troponin

tropomyosin

actin

troponin

tropomyosin

actin

troponin

myosin binding site

actin

tropomyosin

troponin

Ca2+

Ca

2+

Ca2+

Ca2+

Ca2+

Ca

2+

Ca2+

Ca2+

Calcium ions are released from the sarcolemma after

stimulation from the T system

Ca

2+

Ca2+

Ca2+
Ca2+

Ca

2+

Ca2+

Ca2+
Ca2+

the calcium ions bind to the troponin and changes its shape

Ca

2+

Ca2+

Ca2+
Ca2+

the calcium ions bind to the troponin and changes its shape

Ca

2+

Ca2+

Ca2+
Ca2+

Ca

2+

Ca2+

Ca2+
Ca2+

Ca

2+

Ca2+

Ca2+

the troponin displaces the tropomyosin and exposes the

myosin binding sites

Ca2+

Ca

2+

Ca2+

Ca2+
Ca2+

Ca

2+

Ca2+

Ca2+
Ca2+

Ca

2+

Ca2+

Ca2+

the bulbous heads of the myosin attach to the binding

sites on the actin filaments

Ca2+

Ca

2+

Ca2+

Ca2+
Ca2+

Ca2+

Ca2+
Ca2+

Ca2+

Ca2+
Ca2+

the myosin heads change position to achieve a lower

energy state and slide the actin filaments past the
stationary myosin

Ca2+

P i Pi P i A

Ca2+
Ca2+

P i Pi Pi A

P i Pi P i A

Pi Pi Pi A

Pi Pi Pi Ca
A 2+

Ca2+

P i Pi P i A

Ca2+

Pi Pi Pi A

Pi Pi Pi Ca
A 2+

Ca2+

P i Pi P i A

Ca2+

ATP binds to the bulbous heads and causes it to become

detached

Pi Pi Pi A
P i Pi P i A

P i Pi P i A

Ca2+

Ca2+
Ca2+

ATP binds to the bulbous heads and causes it to become

detached

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

Ca2+

Ca2+
Ca2+

hydrolysis of ATP provides the energy to re-cock the heads

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

Ca2+

Ca2+
Ca2+

hydrolysis of ATP provides the energy to re-cock the heads

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

Ca2+

Ca2+

Ca2+

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

Ca2+

Ca2+

Ca2+

calcium ions are re-absorbed back into the T system

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

calcium ions are re-absorbed back into the T system

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

the troponin reverts to its normal shape and the tropomyosin

move back to block the myosin binding sites

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

the troponin reverts to its normal shape and the tropomyosin

move back to block the myosin binding sites

Pi
Pi Pi A
Pi

Pi
Pi Pi A

Pi Pi A

the troponin reverts to its normal shape and the tropomyosin

move back to block the myosin binding sites

Pi
Pi Pi A
Pi

Pi
Pi Pi A

phosphocreatine regenerates ATP

Pi Pi A

Pi

Pi Pi A

Pi
Pi Pi A

phosphocreatine regenerates ATP

Pi Pi Pi A

Pi Pi Pi A

P i Pi Pi A

phosphocreatine regenerates ATP

P i Pi Pi A