Scribd Logo
Upload

Welcome to Scribd!

  • Effect of agents on bronchus smooth muscle

    Uploaded by

    Nym Angga Santosa
    20 views16 pages
    The autonomic nervous system affects bronchial smooth muscle. The sympathetic division causes bronchodilation via beta-2 receptors, while the parasympathetic division causes bronchoconstriction via muscarinic receptors. In asthma, the parasympathetic division is hyperactive, contributing to hyperreactivity. Drugs that act as bronchodilators include beta-2 agonists, methylxanthines, and muscarinic antagonists. They work by increasing cAMP levels and relaxing smooth muscle. Corticosteroids reduce inflammation in asthma by inhibiting phospholipase A2 and reducing the production of inflammatory mediators.

    Original Description:

    lecture obat asma

    Original Title

    10. Pharnaco for Asthma

    Copyright

    © © All Rights Reserved

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    The autonomic nervous system affects bronchial smooth muscle. The sympathetic division causes bronchodilation via beta-2 receptors, while the parasympathetic division causes bronchoconstriction via muscarinic receptors. In asthma, the parasympathetic division is hyperactive, contributing to hyperreactivity. Drugs that act as bronchodilators include beta-2 agonists, methylxanthines, and muscarinic antagonists. They work by increasing cAMP levels and relaxing smooth muscle. Corticosteroids reduce inflammation in asthma by inhibiting phospholipase A2 and reducing the production of inflammatory mediators.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    20 views16 pages

    Effect of agents on bronchus smooth muscle

    Uploaded by

    Nym Angga Santosa
    The autonomic nervous system affects bronchial smooth muscle. The sympathetic division causes bronchodilation via beta-2 receptors, while the parasympathetic division causes bronchoconstriction via muscarinic receptors. In asthma, the parasympathetic division is hyperactive, contributing to hyperreactivity. Drugs that act as bronchodilators include beta-2 agonists, methylxanthines, and muscarinic antagonists. They work by increasing cAMP levels and relaxing smooth muscle. Corticosteroids reduce inflammation in asthma by inhibiting phospholipase A2 and reducing the production of inflammatory mediators.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 16

    Learning objective

    Describe the effect of ANS and other agents


    to bronchus smooth muscle, and able to
    describe the mechanism of action and the
    side effects of drugs used as bronchodilator
    Role of ANS
    on bronchiolar smooth muscle

    Sympathetic division
    - bronchodilatation (2 receptor)
    Parasympathetic division
    - vagus nerve:
    . Bronchoconstriction (M receptor)
    . Secretion of mucus

    In asthma bronchiale there is hyperactivity of


    the parasympathetic division and may
    contibute to the hyperreactivity.
    Effect of other agents to bronchial smooth muscle

    L c AMP M

    H1
    cAMP :
    Bronchodilatation
    Mediator release
    The high level of c GMP:
    .release of mast cell mediators
    .bronchoconstriction
    .increased secretion of mucus
    .mucosal edema
    .leucocyte infiltration
    Histamine

    PG F2

    ECF. A
    Mast
    cell
    SRS.A

    Leukotriene

    Cytokine
    Sign and symptom of bronchial asthma

    - Bronchoconstriction

    - Mucosal edema

    - Inflammation

    - Mucus secretion
    ATP

    Bronchodilatation AC +
    B2
    +
    agonist
    cAM
    +
    P Theophylline
    PDE
    _- -

    5AMP
    Bronchial
    tone
    Ach
    Adenosine
    + +

    - - Theophylline
    Muscarinic
    Antagonist
    Bronchoconstrictio
    Exposure to antigen

    Avoidance
    -
    Ag Ab reaction ( Ag
    IgE
    on mast cell) - Cromolyn
    - Steroid
    - - zileuton

    ( Mediators )
    Histamine,
    ECF.A,
    - agonist SRS.A, -Steroid
    -Theophylline -Cromolyn
    leukotriene,
    -Muscarinic antagonis -Zafirlukast
    - Cytokine -
    -Zafirlukast

    Early response
    Late
    Bronchoconstriction
    Response
    inflammation
    Acute Bronchial hyperreactivity
    Bronchodilator

    agonist

    Muscarinic antagonist

    Methylxantine
    agonist
    Non selective
    Epinephrine
    Ephedrine
    Isoprotrenol

    Selective 2
    Terbutalin
    Salbutamol (albuterol)
    Salmeterol
    Clenbuterol
    Muscarinic antagonist

    Non selective ( atropin )


    ( M1, M2, M3 )

    Selective ( ipratropium )
    ( M3 )
    Methylxanthine

    Caffeine

    Theobromine

    Theophylline ( aminophylline )
    Antiinflammatory

    Corticosteroid
    Prednisone
    Prednisolone
    Methylprednisolone

    Inhibit release of mediator


    Cromolyn
    Ketotifen
    Nedocromil

    Leukotriene antagonist
    Corticosteroid
    Activated GREs Substance ?

    Prevent inflammation & alergy

    Reduced activity of Phospholipase A2

    Phospholipid
    Phospholipase A2

    Arachidonic acid
    Lipoxygenase Cyclooxygenase

    Leukotriene PG

    R. leukotriene R. PG

    You might also like