DASAR-DASAR

BIOLOGI MOLEKULER

NI NYOMAN AYU DEWI

Eukaryotic and Prokaryotic Cells
thenaturalhistorian.com
 ASAM NUKLEAT
Terdapat pada nukleus
Asam gugus fosfat
Polimer dari nukleotida
FOSFAT + GULA PENTOSA + BASA
NITROGEN

DEOXYRIBO NUCLEIC
ACID
RIBO NUCLEIC ACID
NUCLEOSIDE
NUCLEOTIDE

AMP ADP ATP

NUKLEOTIDA
 DNA
Double helix (nucleotide chain)
Nucleotide purine (adenine = A
& guanine = G) pyrimidine
(cytosine = C & thymine =T)
Sugar: Deoxyribose
Complementer
A - T 2 hydrogen bonds
G - C 3 hydrogen bonds
 DNA

Anti paralel
Contain genetic information
Template for
Replication
Transcription
 Watson and Crick
On Feb. 28,
1953, Francis
Crick walked into
the Eagle pub in
Cambridge,
England, and, as
James Watson
later recalled,
announced that
"we had found the
secret of life."
"The structure was too pretty not
to be true."

-- JAMES D. WATSON, "The Double

Helix"
DENATURASI DAN
RENATURASI
 RNA
Single chain (A, G, C & U)
Sugar: Ribose
3 RNAs (mRNA, tRNA, rRNA)
Involve in protein synthesis
 RNA
mRNA messenger RNA, disintesis menjadi protein
(mengalami translasi)

tRNA transfer RNA, membawa asam amino tertentu

yang berhubungan dengan kodon mRNA
yang
bersangkutan

rRNA ribosomal RNA, elemen struktural ribosom,

berperan pada proses pengikatan mRNA
pada
ribosom
 CENTRAL DOGMA
DNA REPLICATION

DNA
TRANSCRIPTION

REVERSE TRANSCRIPTION

RNA TRANSLATION PROTEIN

RNA REPLICATION
 REPLIKASI DNA
Semikonservatif
Primer
DNA template
DNA Polimerase
Topoisomerase
Helikase
SSBP
DNA Ligase
biochemhelp.com
www.tokresource.org
EKSPRESI GEN
TRANSKRIPSI
 TRANSLASI

mRNA

POLIPEPTIDA/PROT
EIN
www.biogem.org
Inisiasi
Elong
asi
Termina
si
www.tokresource.org