GROUP VI

1. BENI DANIL 1620008B

2. DARMA TRI SAMUDRA 1620009B
3. DWI RAHMAWATI 16220063B
4. ANWAR ALIUDIN 1620006B
5. TRUBUS SRIYANTO 1620037B
6. DEDDY RIO SHANGRELA 1620010B
 PRELIMINARY
Systemic infection of Salmonella
germs Acute
Endemic disease in Indonesia
75% of cases> 5 years old
Clinical symptoms of children are lighter than adults
 Factors Affecting the Travel of Salmonella
Infectious Diseases
Barier pejamu
Local : Local: pH, motility TGI, intestinal flora
General: humoral & cellular immunity
Organism
Amount Bactery
Virulensi (serotipe)
Resistance to antibiotics
 CLINICAL SYMPTOMS
CLINICAL SYMPTOMS ARE NOT TYPICAL (CHILD)
Fever 7 days
Gastrointestinal symptoms
gag
diarrhea / obstipation
bloated Delirium
consciousness decreases The big boy
RESEMBLES AN ADULT LOOKS
toxic, dehydrated,
Tifoid tongue,
hepatomegaly, splenomegaly
 LABORATORIUM
Peripheral blood
leukopenia, an-eosinophilia,
relative lymphocytosis
When Platelet is severe
Improved LED,
Increased transaminase enzyme
Serological Test IgM & IgG
Salmonella typhi cultures
 DIAGNOSTIC TESTS

Widal Test,
DNA tracker (DNA probe),
IgG protein outer membrane,
Immunoblotting (Typhi-dot),
PCR (polymerase chain reaction)
 WIDAL TEST

Detect anti-body O & H with agglutination,

Aglutinin 0,
Increasing the end of Week I (hr 6-8),
Disappear 6-12 months,
Diagnostics:
- Titer 1/40
- Titer 1/200
- Titer convalesens> 4X acute
 COMPLICATION

INSIDE THE OUTSIDE THE

GASTROINTESTINAL TRACT GASTROINTESTINAL TRACT

peritonitis, encephalitis,
bleeding, pneumonia,
meningitis,
perforation osteomyelitis,
hepatitis
 TREATMENT

Supportive.
fluids, diet.
electrolyte.
acid base
Causal treatment
medicamentous (antibiotics, corticosteroids)
surgery (treatment of complications)
 SUPPORTIVE TREATMENT
Fluid maintenance,
solution D5: NaCl 0.9% (3: 1)
added 12.5% every 10 temperature increase.
Diet.
eat soft.
reduce fiber,
a stimulating substance.
not too tight.
Acid base correction.
Electrolyte correction.
 ANTIBIOTIC TREATMENT

Chloramphenicol
100mg / kgBB / day orally, maximum 2 grams, 10
hr (no leukocyte <2000 / Ul)
Cotrimoxazole
6mg / kgBB / day, 10 days
Amoxicillin
100 mg / kgBW / day, 10 days
 KAUSAL TREATMENT
Ceftriaxone (3rd generation cephalosporins)
80 mg / kg / day
intravenous, intramuscular, per-infusion
long treatment 5 days i
Cefixime (3rd generation cephalosporins)
20 mg / kgBW / day
per-oral,
long treatment 10 days
Quinolones
not recommended <14 years (experimental animals: cartilage
arthropathy), FDA 1997
 COMPLICATION TREATMENT
Encephalopathy
dexamethasone 1-3 mg / BB / day, 3-5 days
Peritonitis, gastrointestinal bleeding fasting,
parenteral nutrition, blood transfusion (on indication)
Perforation
laparatomi
Supportive
Liquids, dehydration correction, acidosis,
hypoelecrolithemia
 PREVENTION

Individual hygiene,
Environmental hygiene,
Eradicate careers,
Hygiene in child care,
Transmission in hospital (nosokomial),
Vaccinations.
 ACTIVE IMMUNIZATION
Capsular Vi polysaccharide
injection of Typhim Vi,
intramuscularly
polysaccharide vaccine, conjuncture
given at age> 2 years
repeat every 3 years
Ty 21-a
Oral, Vivotive: 3 doses interval of a day interval
given at age> 6 year
 CONCLUSION
Typhoid fever of children is especially found in children> 5
years
Clinically lighter than adults,
The younger the child's age, the clinically invisible
Sensitive, specific, easy and inexpensive investigations are
required
The drug of choice: chloramphenicol
Prevention: improving hygiene & vaccines