Conversion of dose from mg/kg to mg/m2

Species Wt (kg) K Km SAE

Human 60 10.6 37 1:1
Mouse 0.02 9.0 3 12 : 1
Rat 0.10 9.0 5.2 7:1
Hamster 0.05 9.1 4.1 9:1
Monkey 2.5 11.8 11.5 3 :1
Dog 7- 8 10.1 19 -19.8 2 :1

Conversion factor : Km = 100 (W)0.33 (K) -1

For 60 kg human : Km = 100 (60)0.33 (10.6) -1 = 37

• Dose (mg/m2) = Km. Dose (mg/kg)

Example:
ED50 of drug in rat = 50 mg/kg = 5.2 x 50 = 260 mg/m2

Km animal
• Human dose (mg/kg) = Animal dose (mg/kg) x --------------
Km human
Example:
Mouse dose
Human dose (mg/kg) = -------------------- (mg/kg)
12
• Example:

LD10 (or MTD) in mice = 100 mg/kg

Then MTD for 60 kg human = 100/12 = 8.3 mg/kg
= 37 x 8.3 = 307 mg/m2

Dose in 100 g rat = 7 mg = 70 mg/kg

Then, dose in 60 kg human = 70/7 = 10 mg/kg
= 37 x 10 = 370 mg/m2

Dose in 100 g rat = 10 mg = 100 mg/kg

Then, dose in 8 kg dog = 100 mg/kg x 7/2 = 350 mg
= 350/8 = 44 mg/kg
= 19.8 x 44 = 866 mg/m2