Dr .

Nelly, Mked (Ped)SpA

 > 5mm  positif pada
imunocompromised, pasien HIV,
kanker, gizi buruk, kontak erat TB
aktif

 10 mm pasien dgn risiko Tb dan

daerah prevalensi tinggi Tb

 15 mm positif pada pasien kondisi

apapun
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 Dosage of antituberculosis drug
2 Time/week
Daily dose
Drugs (mg/Kg/day)
dose Adverse reactions
(mg/Kg/dose))
Isoniazid 5-15 15-40 Hepatitis, peripheral neuritis,
(INH) (300 mg)) (900 mg)) hypersensitivity
Gastrointestinal upset,skin reaction,
Rifampicin 10-15 10-20 hepatitis, thrombocytopenia,
(RIF) (600 mg)) (600 mg) hepatic enzymes, including orange
discolouraution of secretions

Pyrazinamide 15 - 40 50-70 Hepatotoxicity, hyperuricamia,

(PZA) (2 g) (4 g) arthralgia, gastrointestinal upset

Optic neuritis, decreased visual

Ethambutol 15-25 50 acuity, decreased red-green colour
(EMB) (2,5 g) (2,5 g) discrimination, hypersensitivity,
gastrointestinal upset

Streptomycin 15 - 40 25-40
Ototoxicity nephrotoxicity
(SM) (1 g) (1,5 g)

When INH and RIF are used concurrently, the daily doses of the drugs are reduced

9/4/2019 National consensus of tuberculosis in children, 2001

39
 WHO IDAI
 H : 30 mg  H : 50 mg
 R : 60 mg  R : 75 mg
 Z : 150 mg  Z : 150 mg

9/4/2019 40
  WHO:
 INH: 4-6 mg/kgBW
 BW grouping: too many
 not practical
 hard to remember
 a gap for BW 30-33 kg
 IDAI
 INH: 5-10 mg/kgBW
 simple BW grouping
 more friendly both for doctor and patient

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