DRUG UTILIZATION REVIEW OF ORAL- ANTIHYPERLIPIDEMIC DRUGS IN THE TREATMENT OF 50

DYSLIPIDEMIA IN A PRIVATE HOSPITAL

SHASHIDHARAN MENON1 ,TAN MIN , JAASMINERJIIT KAUR11

Department of Clinical Pharmacy, School of Pharmacy, KPJ Healthcare University College, Kota Seriemas, Nilai, NS, Malaysia.
BACKGROUND OF STUDY METHODOLOGY RESULTS & DISCUSSION
Study Design Retrospective Observation Demographic January February March Total The number of male patients much
Dyslipidemia is a group of disorders of lipoprotein
higher than the female ratio of 2 to 1.
metabolism include elevated triglycerides, Low Density Study Population Outpatient Pharmacy Patient Variables n (%) n (%) n (%) (N)
Range of 45 to 64 years old patient
Lipoprotein (LDL) cholesterol,, and/or low High-Density Study Location KPJ Seremban Specialist Centre Gender contributed the highest mainly high rick
Lipoprotein (HDL) and increment of hepatic secretion of Study Duration January 2019 to March 2019 Male 297 (65.6) 284 (64.1) 353 (62.9) 934 for cardiovascular complication. Malays
large triglyceride-rich Very Low-Density Lipoprotein Inclusion Criteria  Patients aged above 18 years Female 156 (34.4) 159 (35.9) 208 (37.1) 523 were highest this mainly due to
(VLDL). Hence in order to treat or used as prophylaxis distribution of population by Aris., 2018.
 New and existing cases prescribed lipid modifying drug. Age
treatment, anti-hyperlipidaemia drugs are prescribed to
control the dyslipidemia condition . Exclusion Criteria  Patients with incomplete information such as age, 25-44 59 (13.0) 65 (14.7) 94 (16.8) 218 Lipitor 80mg had highest rate 5 DDD per
gender, race, medication taken and others. user per day due to 1 & 2 line prevention
45-64 302 (66.7) 296 (66.8) 353 (62.9) 951
treatment for reducing cholesterol and
Throughout these years, the. use of anti-hyperlipidemic  Duplicate prescription in the same month. 65-84 90 (19.9) 81 (18.3) 112 (20.0) 283 minimize the risk of cardiovascular events
drugs therapy had increase progressively and the cost of  Walk in prescription from other hospitals. ≥85 2 (0.4) 1 (0.2) 2 (0.4) 5 compliance to practice guidelines
the anti-hyperlipidemic drugs had increased which may Tools  Data Collection Form regarding use of statins. (Sim et al., 2007).
Race
be due to several reasons which including the availability  IBM SPSS Statistics Version 20
of latest generation drugs in combination form which Malay 355 (78.4) 344 (77.7) 435 (77.5) 1134 Ezetrol 10mg is lowest rate per residents
 Microsoft Word 2013 Chinese 35 (7.7) 30 (6.8) 53 (9.4) 118 per day 0.077 DDD per 1000 population
may cause the price of the medication increase.
Data Collection & The out-patient pharmacy prescriptions screened, filtered per day mainly medication cost increase
Indian 57 (12.6) 68 (15.3) 65 (11.6) 190 the financial burden for the patient due
Hence analysis of drug utilization review is important to Management based inclusion and exclusion and arranged categorically Others 6 (1.3) 1 (0.2) 8 (1.4) 15 to the long therapeutic duration.
identify the prescribing pattern especially in private based type of anti-hyperlipidemic drugs, Medical Record
hospital. Number was recorded and traced in KPJ Clinical
Information System for patient demographic data, dosage
OBJECTIVE form, dose, frequency and quantity supplied transcribed to
 To identify the demographic patent (age, gender, data collection form.
race and clinics) prescribed with anti-hyperlipidemic Data Analysis Data was tabulated in SPSS, analysed as below
agent in outpatient pharmacy department in KPJ
Seremban Specialist Hospital.

 To compare monthly Defined Daily Dose (DDD)

prescribed anti-hyperlipidemic drugs with WHO
DDD standard dispense in outpatient pharmacy
department in KPJ Seremban Specialist Hospital.
SIGNIFICANT OF STUDY
The outcome enables private hospital to determine their
compliance to World Health Organization Defined Daily
Dose standard and help them in development of drug
policy related to anti-hyperlipidemic drug usage.
Ethical Clearance KPJUC/RMC/SOP/EC/2019/193
CONCLUSION
In a conclusion, the drug usage pattern of the anti-hyperlipidemic drugs was
greatly impacted based on individual’s demographic characteristics, Defined
Daily Dose of anti- hyperlipidemic drugs, prescribing characteristics and cost
of the medication. Its concluded the prescribing pattern of anti- REFERENCES ACKNOWLEDGEMENT
hyperlipidemic drugs was in range to WHO DDD level but more intensive  Aris, T., Nik Abd Rashid, N. R., Ariffin, M. A. I., & Ismail, I. (2018). National Health and
Morbidity Survey (NHMS) 2017, (April). I also wish to thank KPJUC for assisting advancement of my
study in-term of duration, cost analysis and policies of patient prescribe  Sim, D. S., Jeong, M. H., Cho, K. H., Ahn, Y., Kim, Y. J., Chae, S. C., ... & Cho, M. C. (2013). research and my heartfelt thanks to pharmacists in-
Effect of early statin treatment in patients with cardiogenic shock complicating acute
should be review for concrete compliance towards the guideline. myocardial infarction. Korean circulation journal, 43(2), 100-109. charged of KPJ Seremban Specialist Hospital, Mr. Shafiq.