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  • Blood Clotting

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    Hemostasis is the process by which bleeding is prevented through a combination of vascular constriction, platelet plug formation, and blood clotting via a complex cascade of chemical reactions involving coagulation factors. This process occurs rapidly through a balance of procoagulant and anticoagulant factors, and can be disrupted by deficiencies in coagulation factors, diseases of the liver, or medications like warfarin that prevent clotting.

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    Hemostasis is the process by which bleeding is prevented through a combination of vascular constriction, platelet plug formation, and blood clotting via a complex cascade of chemical reactions involving coagulation factors. This process occurs rapidly through a balance of procoagulant and anticoagulant factors, and can be disrupted by deficiencies in coagulation factors, diseases of the liver, or medications like warfarin that prevent clotting.

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    19 views12 pages

    Blood Clotting

    Uploaded by

    Apple Computers
    Hemostasis is the process by which bleeding is prevented through a combination of vascular constriction, platelet plug formation, and blood clotting via a complex cascade of chemical reactions involving coagulation factors. This process occurs rapidly through a balance of procoagulant and anticoagulant factors, and can be disrupted by deficiencies in coagulation factors, diseases of the liver, or medications like warfarin that prevent clotting.

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    of 12

    R.

    Hemalatha
    19UBC10
    MLT
     Hemostasis – prevention of blood loss
     Mechanisms:
    1) Vascular constriction
    2) Formation of a platelet plug
    3) Formation of a blood clot
    4) Growth of fibrous tissue
     Fast process
     Procoagulants and anticoagulants
     Complex cascade of chemical reactions
     Blood coagulation factors
     Formation of prothrombin activator
     Extrinsic pathway
     Intrinsic pathway
     Endothelial surface factors (smoothness,
    glycocalyx, thrombomodulin)
     Antithrombin III - heparin cofactor
     Coumarin (warfarin)
     Citrate ion, oxalate
     Vitamin K deficiency
     Diseases of the liver
     Hemophilia
     Thrombocytopenia
     Hemophilia A - abnormality or deficiency of
    Factor VIII
     Recessive sex-linked, X chromosome
    disorder
     Guyton, Hall: Textbook of Medical Physiology

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