Professional Documents
Culture Documents
Amiruddin Eso
Department of Physiology
Faculty of Medicine
Halu Oleo University
STRUCTURE
Structure of gastrointestinal system
Gastrointestinal tract; oral cavity, pharynx,
esophagus, stomach, small intestine, large
intestine, rectum, and anal canal
Accessory organs; tongue, teeth, salivary
glands, liver, and gall bladder
FUNCTION
Breaking down food and supplying the body with the
water, electrolytes, and nutrients to sustain life.
Before can be used, food must be:
ingested
digested
absorbed
All of these processes involve coordinated movement
of muscle and secretion of various substances
INGESTION
TONGUE
TEETH
ACCESSORY SALIVARY GLANDS
ORGANS PANCREAS
LIVER
GALL BLADDER
INGESTION
SECRETION
FUNCTION DIGESTION
MOVEMENT
ABSORPTION
MOTILITY OF GI TRACT
The basic mechanisms of GI movement is
peristaltic. Peristaltic is a coordinated pattern of
smooth muscle contraction and relaxation
Peristaltic helps move food through the pharynx
and esophagus and within the stomach. Peristaltic
plays a minor role in propelling food through the
intestine
During peristaltic, contraction of small section of
proximal muscle is followed immediately by
relaxation of the muscle just distal to it. The
resulting wavelike motion.
MASTICATION
Function of Mastication
Functional components
The three functional parts of the stomach are
the fundus, corpus, and antrum
Gastric contents are isolated from other parts
of the GI tract by the lower esophageal
sphincter proximally and by the pylorus
distally
The antrum and pylorus are anatomically
continous and respond to nervous control as a
unit
MOTILITY OF STOMACH
Musculature
Each muscle layer forms a functional
syncytium and therefore acts as a unit
In the fundus, where the layers are relatively
thin, strength of contraction is weak; in the
antrum, where the muscle layers are thick,
strength of contraction is strong
The stomach and duodenum are divided by a
thickened muscle layer called the pyloric
sphincter
MOTILITY OF STOMACH
Innervation
Intrinsic innervation directly responsible for
peristaltis
The myenteric plexus (Auerbach’s) is located
between the layers of the circular and longitudinal
muscles of the stomach
The submucosal plexus (Meissner’s) is located
between the layers of the circular muscle and mucosa
on the luminal surface of the stomach
Extrinsic through autonomic nervous system:
Sympathetic, via the celiac plexus (inhibits motility)
Parasympathetic, via the vagus nerve (stimulates
motility)
Function of Motility
Gastric emptying
Each time the chime pushed against the pyloric
sphincter, a small amount (2-7 ml) may escape
into duodenum
The amount of chyme passing the pylorus
depends on the size of the particles
Liquids empty much faster than solids. The rate
of liquids emptying is proportional to pressure
within the upper portion of stomach, which
increase slowly during the digestive period
Function Disorder of Motility
Vomiting or emesis
Initiation
The vomiting center. Directly activated by afferent
fibers or by irritation due to injury or increases in
intracranial pressure
Chemoreceptor trigger zone. Activated by afferent
nerves originating within the GI tract or by circulating
emetic agents
Mechanical sequence of vomiting
Begins with deep inspirasion followed by the closing
of the glottis
Intestine propels chyme into upper region of stomach
Increase in abdominal pressure forces the chyme into
esophagus and out of the mouth
Vomiting Reflex
INTESTINAL MOTILITY
Contractile activity
Contractile activity of the smooth muscle lining
the small intestine serve two functions:
Mixing the chyme with digestive enzymes and bile to
facilitate digestion and absorption
Propelling the chyme from the duodenum to the colon
It usually takes about 2-4 hours for the chyme to
move from one end of the small intestine to the
other
INTESTINAL MOTILITY
Types of movements
Segmentation is the most common type of
intestinal contraction
Peristaltic contractions is not considered to be
an important component of intestinal transit
INTESTINAL MOTILITY
Segmentation contractions
During segmentation, about 2 cm of the intestinal
wall contracts, forcing the chyme throughout the
digestive period
When the muscle relaxes, the chyme returns to the
area from which it was displaced
This back-and-forth movement enables the chyme
to become mixes with digestive enzymes and to
make contact with the absorptive surface of the
intestinal mucosa
Segmentation occur about 12 times/min in the
duodenum and 8 times/min in the ileum. The
contraction last for 5-6 seconds
INTESTINAL MOTILITY
Regulation of intestinal motility
Segmentation occur only if the slow waves produce
spikes potentials which is controlled by pacemaker
cells within the wall of the intestine and is not
infuenced by neural activity or circulating
hormones
The frequency of segmentation is directly related to
the frequency of the slow wave
The strength of segmentation is proportional to the
frequency of the spike potentials generated by slow
wave
Slow wave amplitude is increased by gastrin, CCK,
motilin, and insulin; and decreased by secretin and
glucagon
SECRETORY FUNCTION OF
GASTROINTESTINAL SYSTEM
INTRODUCTION
• Throughout the gastrointestinal tract secretory
glands serve two primary function;
– To produce digestive enzymes;
– To provide mucus for lubrication and protection
• Most digestive secretions are formed only in
response to the presence of food in the
gastrointestinal tract
• The types of enzyme and its component are
varied according to the types of food present.
GENERAL PRINCIPLES
• Functions of gastrointestinal secretions
– Transport
– Digestion
– Protection
– Absorption
• The type of secretory glands
– Mucus gland or mucus cells (Goblet cells)
– Pits; invagination of surface lining epithelial
– Tubular glands (stomach and upper duodenum)
– Complex glands (Salivary glands, pancreas and liver)
• Basic mechanism of secretion by glandular cells
– Secretion of organic substances
– Water and electrolyte secretion
• Basic regulatory mechanism of glandular cells
Basic Mechanism of Secretion
Secretion of Organic Substances (proteins)
1. The nutrient material needed for formation of secretion
must diffuse or actively transported from the capillary into
the base of glandular cell
2. ATP from the mitochondria, along with appropriate
substrates, is then used for synthesis of the organic
substances
3. The secretory materials are then transported to the Golgi
complex
4. In the Golgi complex the material are modified before
discharged into the cytoplasm in the form of secretory
vesicles, which are stored in the apical ends of the secretory
cells
5. These vesicles remain stored until nervous or hormonal
stimulation cause them to extrude their contents
Basic Mechanism of Secretion
Secretion of Water and Electrolyte
1. Nerve stimulation on basal portion of the cell membrane,
causing active transport of Cl- ions to the inside the cell
2. The resulting increase in electronegativity inside the cell the
causes positive ions also move to the interior of the cell
3. The excess of both these ions inside the cell creates an
osmotic force that pulls water to the interior, thereby
increasing the hydrostatic pressure inside the cell and
causing the cell to swell
4. The pressure in the cell then results in ruptures of secretory
border of the cell causes flushing of water, electrolyte, and
organic materials out of the glandular cell into the lumen of
the gland
Basic Regulatory Mechanism
of Glandular Cells
• Effect of Local Contact
– The mechanical present of food causes the glands to
secrete moderate to large quantities of digestive juice
• Effect of enteric nervous system
– Tactile stimulation
– Chemical irritation
– Distention of the gut wall
• Autonomic stimulation
– Parasympathetic increase the rate of secretion
– Sympathetic can have dual effect; increase or decrease
the secretion depend on the rate of stimulation
• Hormonal
Basic Regulatory Mechanism
of Glandular Cells
Hormones that regulate secretion
• Gastrin
– Stimulates gastric acid/pepsinogen secretion
• Secretin
– Stimulates pancreatic and bile secretion
• Cholecysokinin (CCK)
– Stimulates pancreatic enzyme secretion and
bile secretion
Basic Regulatory Mechanism
of Glandular Cells
CELLULAR MECHANISMS
• Second messengers
– IP3, calcium, cAMP
• Actions
– alter activity of ion transporters
– alter exocytosis rate of secretory vesicles
– regulate insertion of intracellular
canaliculi
SALIVARY GLANDS AND
SALIVA
Saliva is secreted primarily by three pairs of glands:
1. Parotid, located near the angle of the jaw, are
largest glands and secrete a watery fluid
2. Submandibular, secrete a fluid that contains a
high concentration of proteins and so is
moderately viscous
3. Sublingual, produce viscous fluid
Saliva Function
Hormonal Control
• Secretin (from increased HCl in duodenum)
– stimulates fluid and electrolyte secretion
• CCK (from increased fatty acids, peptides,
amino acids)
– stimulates release of enzymes
Nervous System
• Parasympathetic input
– initiates secretion during cephalic and gastric phases
Thank You