PENIS

ACCESSORY GLANDS
EXCRETORY GENITAL
DUCTS

INTRATESTICULAR DUCTS

TESTES of the

MALE

SYSTEM
HISTOLOGY

REPRODUCTIVE
 DUCTS
ACCESSORY GLANDS
GENITAL

TESTES
PENIS

INTRATESTICULAR
DUCTS
EXCRETORY

***Interstitial tissue
***Spermatogenesis
***Clonal nature of Male Germ Cells
***Spermiogenesis
***Sertoli cellls
 PENIS
ACCESSORY GLANDS
EXCRETORY GENITAL
DUCTS

INTRATESTICULAR DUCTS

TESTES
 PENIS
ACCESSORY GLANDS

EXCRETORY GENITAL
DUCTS

INTRATESTICULAR DUCTS

TESTES
 PENIS

ACCESSORY GLANDS
EXCRETORY GENITAL
DUCTS

INTRATESTICULAR DUCTS

TESTES
 PENIS
ACCESSORY GLANDS
EXCRETORY GENITAL
DUCTS

INTRATESTICULAR DUCTS

TESTES
 END 
Thank You
for listening!

PENIS
ACCESSORY GLANDS
EXCRETORY GENITAL
DUCTS

INTRATESTICULAR DUCTS

TESTES
 a

b
c

e
Interstitial Outside the seminiferous tubules
Tissue *Leydig cells→*testosterone
*connective tissue
 Spermatogenesis

Begins at puberty
*Sertoli cells
*blood-testis barrier (BTB)
*Spermatogonium(2n)→mitosis
*type A(dark) (stem /progenitor)
type B (Pale)
(B→P…Proceed)
(type B…crosses the BTB)
*Primary Spermatocyte(2n)
-prophase I
*Secondary Spematocytes(n)
-meiosis 2
*Spermatids(n)
→will undergo
spermiogenesis
to form LH→Leydig→testosterone
sperms/spermatozoa(n) FSH→Sertoli→ABP
The Clonal Nature of
Male Germ Cells

*Incomplete cytokinesis
*Cytoplasmic/ intercellular bridges
*Spermatogenic syncytium

***Cells at different stages of

development are typically grouped
together along the tubule,
 Spermiogenesis

*final phase of sperm production

Spermatids→sperm/spermatozoa
*temperature-sensitive process
(***Clinical importance/ descent
Scrotal area is about 2o lower
than body temp)
*no cell division
*near the lumen(surface of Sertoli)

This will result/produce

Mature but not functional/mobile
sperms

Nagiging functional na pag daan sa

epididymal duct
 Sertoli Cells

*sustentacular, columnar, large,

(pale) oval nucleus (perpendicular to
basal mem), visible nucleolus

*tight jxns (claudin/occluding)

adherens jxn (cadherin)
*Blood-testis barrier
*basal & adluminal compartment

3 General fxn:
a. Support, protection, and
nutrition of the developing
spermatogenic cells
b. Exocrine and endocrine secretion
Exo(water, nutrients and ABP)
Endo (glycoprotein-inhibin,
fetal→MIS
c. Phagocytosis…
lysosomes….residual bodies
 Seminiferous
Tubules

Site of sperm production

*(spermatogenesis)
Myoid cells
collagenous basement membrane

*Sertoli cells &

Spermatogenic Lineage of cells
-Spermatogonia
-Primary spermatocytes (largest)
-Secondary spermatocytes (rarely seen)
-Spermatids
Straight Tubules
Rete Testis
Efferent Duct/
Vasa efferentia
 Epididymal Duct

Occurs important changes

within
sperm while passing through
the epididymis include:
■ Development of the
competence for independent
forward motility,
■ Maturation of the
acrosome
■ Biochemical and
organizational changes within
the cell
membrane.

(Fluid within the epididymis

contains glycolipid
“decapacitation
factors”)
Vas Deferens
Ejaculatory Duct
 Seminal Vesicles

*mucosal folds are lined with simple

or pseudostratified columnar
epithelial cells rich in secretory
granules
*Presence of mucosal crypts
*The folds extend far into the lumen
of the seminal vesicle.
*LP: primary and secondary folds
*muscularis: inner and outer
horizontal layer and circular in the
middle
*surrounded by adventitia
*makes up about 60-70% of the
ejaculate…includes:
■ Fructose,(nutrition)
■ Prostaglandins(stimulate activity in
the female reproductive tract)
■ Fibrinogen (allow coagulation,
latches on the sperm to the vaginal
wall)
 Prostate Gland

*dense organ, surrounds the

Prostatic urethra
*30-50 tubuloacinar glands
Lined with pseudostratified
columnar epith.
*3 major Zones:
-Transition (5%)-mucosal
-central (25%)- submucosal
-peripheral (about 70%)-main
glands

*PSA(Prostate specific antigen)

*liquefaction
↑PSA indicate BPH
*fibrinolysin

*corpora amylacea
dense amounts of calcified
materials that are protein based
in nature
 Bulbourethral/
Cowper’s Gland

*location: urogenital diaphragm

*several lobules with
Tubuloacinar glands
*Lined with mucus secreting
pseudostratified or stratified
columnar (DI Fiore’s)
***or Simple columnar
epithelium (Jungquiera’s)

*fluid/musus secreted is fro

preparation for the imminent
passage of sperm