Refarat Fix

REFERAT
AUGUST 2020
DIET IN
DERMATOLOGY
By:
Farra Y. Pattipawae
20 18-84-0 57

Supervisor:
dr . Rita S. Tanamal, Sp.KK
INTRODUCTION
Diet comes from the word "diaeta" which
translates to "prescribed way of life".
Diet is related to one's body

Patients usuallyand minddietary advice
require
from a dermatologist, as many health Many conditions occur due to
problems are associated with the diet deficiency or excess of certain
they consume, including dermatological nutrients, some conditions are related
diseases. to abnormal metabolism of certain
Diet plays a very important role in many nutrients.
dermatological conditions. Diet has a definite role and dietary
changes help to control or prevent
certain conditions including
dermatological conditions.
An unbalanced diet causes
nutritional deficiency
1. Katta R, Samir P, Desai MD. Diet and Dermatology : The Role of Dietary Intervention In Skin Disease. The Journal of Clinical Aesthetic. Baylor College of medicine,
Houston, Texas. 2014; 7(7): 46-51
2. Vora RV, Khushboo MH, Shah AJ, Patel DR. Diet in dermatology : a Review. J Dermatol Venereol. 2020; 40:69-75
LITERATURE
REVIEW
The skin is the largest organ of the active
metabolic system that functions to protect the
body from injury and infection, helps control
temperature and immunoregulation, and acts as a
storage reservoir for certain nutrients. Nutritional imbalances
Poor eating or imbalanced
1 nutritional value,
age factor nutritional diet free radicals climate sunlight
2 Organ functional disorders
high metabolic requirements, the skin has relatively high
requirements for energy, protein and other essential
nutrients.
Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.
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01 VITAMIN A
02 VITAMIN B Complex (Biotin, B-6, B-12,

Niacin, riboflavin)
03 VITAMIN C
04 VITAMIN D
05 VITAMIN E
06 VITAMIN K
07 ZINC
08 SELENIUM
TYPES OF 09 LIKOPEN
NUTRIENTS
VITAMIN A
01 The human epidermis contains a large amount of vitamin A
Vitamin A cannot be synthesized; it must be obtained through the

diet consumed.
Consumption of vitamin A depends on the source of retinoids
(animal sources) and carotene (plant sources) in the diet.
Vitamin A, also called retinol, is associated with intracellular

proteins that direct these nutrients to the cell nucleus, controlling
the synthesis of other proteins.
These nutrients not only stimulate glycoprotein synthesis, ensure
skin protection and maintain moisture, also inhibit the synthesis of
high molecular weight ceratine.
If there is a lack of retinol, there is a high risk of developing
follicular hyperkeratosis
1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

2. Bronsnick T, Murzaku EC, Rao BK. Diet in Dermatology : Part I. Atopic dermatitis, acne, and nonmelanoma skin cancer. J Am Acad
VITAMIN A
01 Vitamin A is available in multivitamins and as a standalone
supplement, often in the form of retinyl acetate or retinyl
palmitate.
Multivitamin supplements typically contain 750-3,000 mcg of
RAE (2,500-10,000 IU) vitamin A, often in the form of retinol
and beta-carotene.
28% -37% of the general population take supplements
containing vitamin A.

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02
VITAMIN B COMPLEX
(BIOTIN, B-6, B-12, RIBOFLAVIN,
AND NIACIN)
Biotin, or vitamin B7, is an Place Your Picture Here And
It is most abundant in whole grains essential coenzyme for 5 Send To Back
and whole grain cereals, as well as carboxylases involved in fatty acid
fortified cereal and grain products. synthesis, amino acid catabolism,
and gluconeogenesis.
Adequate biotin intake is 30ug /
Vitamin B Klompeks is useful for day for adults  balanced diet Your Picture Here
reducing dryness and itching on the including foods containing biotin,
skin. such as meat, eggs, fish, nuts,
seeds, and certain vegetables.
Riboflavin or vitamin B-2  meat,
The benefits of biotin
beans and leafy green vegetables.
supplementation remain
While niacin can also be obtained
unfounded, and its use can lead to
from poultry, fish, beef, peanut butter
misdiagnosis of potentially
and beans.
serious conditions.
2. Bronsnick T, Murzaku EC, Rao BK. Diet in Dermatology : Part I. Atopic dermatitis, acne, and nonmelanoma skin Recommended Dietary Allowances (RDAs) for Bio
cancer. J Am Acad Dermatol. 2014; 71(6): 1039.e1-1039.e12.
Place Your Picture Here

Nicotinamide or niacinamide is a derivative of niacin (vitamin B3) and
Place Your Picture Here
is the water-soluble part of the vitamin B group, which is obtained
through the diet.

03 VITAMIN C
destroy free radicals inside and outside cells. Helps in the formation of tissue particles,
wound healing and absorption of iron. Helps prevent bruising and keeps teeth healthy.
Vitamin C can also be obtained from oranges, berries, peppers, potatoes, garlic,
onions, leafy green or dark green vegetables (spinach), apples, cabbage, sprouts and
melons.
Vitamin C is important because of its antioxidant content, as well as its antihistamine
effect, can prevent skin infections and heal wounds, produce collagen and elastin to
tighten skin, support healthy gums and supple blood vessels.

Supplements usually contain
vitamin C ascorbic acid,
which has a bioavailability
equivalent to ascorbic acid that
occurs naturally in foods, such
as orange juice and broccoli.
Other forms of vitamin C

supplements include sodium
ascorbate; calcium ascorbate;
other ascorbate minerals;
ascorbic acid with
bioflavonoids; and combination
products
Recommended Dietary Allowances (RDAs) for

VITAMIN C
Vitamin C
04
Pla
ce
Yo
ur
VITAMIN
D
P ict
ure
He
re
An
dS
en Vitamin D is a fat-soluble vitamin that is naturally available in
d To
B ac
k small amounts from food and is available as a dietary
supplement.
Vitamin D is also produced endogenously when ultraviolet light
from sunlight strikes the skin and triggers the synthesis of
vitamin D.
Vitamin D obtained from sun exposure, food, and supplements
Vitamin D has other roles in the body, including modulation of

cell growth, neuromuscular and immune function, and reduction
of inflammation.

VITAMIN D
Recommended Dietary Allowances (RDAs) for
Vitamin D
05 VITAMIN
E Dosage RDA (Recommended Dietary
Allowance), for supplementation used a dose
of 400 IU per day.Vitamin E deficiency: 40-
50 mg per day, children 10 mg / kg per day, 1
month-18 months: 2-10 mg / kg / day, up to
20 mg / kg.
Useful as a protector of fatty
essences in red blood cells and
cell membranes.
This vitamin also acts as an anti-
inflammatory and strengthens the
immune system.
This vitamin, which is often said to be very important for the skin, can Drinking rules: 1-3 capsules per day.
be found in leafy green vegetables, vitamin E is also contained in Store at 25-30 C and protected from
peanuts, red peppers, olives, brown rice, apples, whole grains, sweet light. Discontinue use if allergic
potatoes and legumes.1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604. reactions occur.
VITAMIN 06
K
Vitamin K is essential in the process of
blood clotting and improves blood
circulation, which may help the body heal
areas injured during surgery.
Several forms of vitamin K are used in
dietary supplements, including vitamin K1
as phylloquinone or phytonadione
(synthetic form of vitamin K1) and vitamin
K2 as MK-4 or MK-7.
One study found that phytonadione and
MK-7 supplements were well absorbed, but
MK-7 had a longer half-life.

ZINC
07 meat, seafood, eggs, milk. You can also get zinc from apricots,
cocoa onions.
as it works with vitamin A to maintain and repair skin, supporting
skin strength, elasticity and firmness.
Zinc supplements can be given via zinc sulfate (23% zinc) or zinc
gluconate (14% zinc) Although zinc sulfate has a higher trace
element content of zinc, zinc gluconate is reported to have a less
bitter taste.
Zinc supplementation has also been shown to play a role in the
wound healing process. A controlled study of 20 young men who
underwent pilonidal sinus excision found that the group treated
with zinc sulfate 220 mg 3 times per day recovered at a much
faster rate.

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Helps maintain healthy hair and nails, increases immunity,
works together with vitamin E to protect cells from damage 
Garlic, brazil nuts , meat, eggs, poultry, seafood.
Selenium is important for reproduction, thyroid gland function,

DNA production, and protects the body from damage caused by
free radicals and from infection.
08
SELENIUM Recommended Dietary Allowances (RDAs) for
Selenium
a carotenoid found in tomatoes and other red fruits and
vegetables.
Lycopene has the most efficient effect on the biological
carotenoid singlet oxygen.
Studies with supplementation of
lycopene oral showed that lycopene has
the effect photoprotective and
prevent erythema are induced by UV.
09LIKOPEN
Apart from vitamins and minerals, to create healthy
skin the body also requires good macro nutrients
Carbohydrate
substance of this nutrient contained in bread, rice
(preferably brown rice) and oatmeal.
Protein
Meat, poultry, eggs, fish, nuts and tofu are the best
sources of protein.
Fat
Found in vegetable oil, poultry fat, soybean oil,
nuts and seeds.
Water
Water is the best source, but you should also get
good fluid intake from fruits, vegetables
and dairy products .

DIET IN
DERMATOLOGICA
L CONDITIONS
01
ATOPIC DERMATITIS
A 2008 Cochrane review assessed food

A 2012 Cochrane review analyzed the
elimination for the treatment of AD  Data
administration of dietary supplements
from 9 trials were reviewed: 6 egg
in patients with atopic dermatitis  The
and milk elimination studies , 1 low-diet diet
studies reviewed were low quality and too
study, and 2 elemental diet studies.
small to provide conclusive evidence on
the benefits of dietary supplements in An egg-free diet increased the severity of
atopic dermatitis. AD in patients with egg-specific serum IgE
Studies investigated the impact of vitamin positive.
D supplementation in patients with AD  For patients with AD and a proven food
In 1 randomized trial, vitamin D allergy, food elimination is appropriate as
supplementation of 1600 IU daily for 2 it can reduce the severity of AD.
months significantly improved the atopic
dermatitis score (SCORAD) and the 3- For patients without a proven food allergy,
item severity score compared to placebo. food elimination is not necessary for the
1. Bronsnick T, Murzaku EC, Rao BK. Diet in Dermatology : Part I. Atopic dermatitis, acne, and
nonmelanoma skin cancer. J Am Acad Dermatol. 2014; 71(6): 1039.e1-1039.e12.
management of AD, as there is no evidence
2. Fomin DA, Handfield K. The Ketogenic Diet and Dermatology: A Primer on Current Literature. J to suggest a benefit.
Cutis. 2020; 105:40-43
Table I. Modification of diet for atopic dermatitis patients and their recommendations and
levels of evidence
Vora RV, Khushboo MH, Shah AJ, Patel DR. Diet in dermatology : a Review. J
Dermatol Venereol. 2020; 40:69-75
02ACNE
Smith et al published 4 intervention studies examining the effects of a low GI / GL diet

versus a high GI / GL diet on acne. In 2 RCTs, the low GI / GL group experienced a
significant reduction in the number of pimples and the free androgen index as well as a
significant increase in insulin sensitivity and IGFBP compared to the high GI / GL
group.
Observational studies have also shown a link between glycemic load and acne. A case-
control study revealed a significant comparison of the high glycemic load between acne
patients and healthy controls, including a multivariate analysis of body mass index
calculations.
The community-based case-control study found that patients consuming a Mediterranean
diet, another low GI diet, were less likely to develop acne.
Dermatol. 2014; 71(6): 1039.e1-1039.e12.
2. Fomin DA, Handfield K. The Ketogenic Diet and Dermatology: A Primer on Current Literature. J Cutis. 2020; 105:40-43
3 SERIES OF STUDIES
Abedamowo et al investigated the association between acne and milk
consumption
retrospective cohort study of 47,355 Prospective cohort study including 6094
women, using data from the Nurses' women with self-reported acne, was
Health Study II, self-reported history of positively associated with total
S W
patients diagnosed with severe acne was consumption of low-fat milk, and
positively related to consumption of skim milk.
total consumption frequency . milk and
skimmed milk.
study on 4273 boys, self-reported

acne was positively associated
O
with skim milk intake alone.
1. Kaimal S, Thappa DM. Diet in Dermatology: Revisited. Indian Journal of Dermatology, Venerology and Leprology. 2010; 76(2): 103-115
2. Dhar S, Srinivas SM. Food allergy in atopic dermatitis. Indian J Dermatol. 2016; 61:645–648.
Table II. Diet modifications for acne patients along with recommendations and levels
of available evidence
Vora RV, Khushboo MH, Shah AJ, Patel DR. Diet in dermatology : a Review. J Dermatol Venereol. 2020; 40:69-75
03
NONMELANOMA SKIN CANCER
A randomized trial found no significant effect of a low-fat diet
on nonmelanoma skin cancer, therefore limiting fatty foods do not need to be
recommended for the prevention of nonmelanoma skin cancer.
Animal studies have shown that the intake of fatty foods

significantly affects the occurrence of Non Melanoma Skin
Cancer (NMSC)  Higher dietary fat reduces the time interval
between ultraviolet (UV) exposure and tumor onset and
increases the number of tumors in mice.
One case-control study revealed lower serum b-carotene and
vitamin A levels in cases with NMSC than in controls, and a
significant inverse association between dietary intake of b-
carotene and NMSC.
case-control study found that vitamin A intake was associated
with a reduced risk of basal cell carcinoma (BCC)
1. Katta R, Samir P, Desai MD. Diet and Dermatology : The Role of Dietary Intervention In Skin Disease. The Journal of Clinical Aesthetic. Baylor College of
medicine, Houston, Texas. 2014; 7(7): 46-51
2. Vora RV, Khushboo MH, Shah AJ, Patel DR. Diet in dermatology : a Review. J Dermatol Venereol. 2020; 40:69-75
Table III. Dietary modifications for patients with nonmelanoma skin cancer and
recommendations and levels of available evidence
Vora RV, Khushboo MH, Shah AJ, Patel DR. Diet in dermatology : a Review. J Dermatol Venereol. 2020; 40:69-75
04PSORIASIS
Diet plays an important role in psoriasis as a supan energy in psoriasis also have
a positive correlation with BMI, which means that psoriasis patients more
severely affected tend to be obese; therefore, weight loss is recommended in
obese psoriatic patients.
Alcohol stimulates the release of histamine, increases your intake of fatty foods,
and reduces your consumption of fresh vegetables and fruits  alcohol intake
should be limited in psoriasis. Your Picture Here
Consumption of fresh fruit and vegetables, such as carrots, tomatoes, broccoli,

oranges and peppers may be beneficial for psoriasis as carotenoids,
flavonoids and vitamin C is high .
A diet containing good sources of folic acid ( fresh green leafy vegetables ,
fruits, organ meats, dry nutritional yeast) and vitamin B12 (yeast, liver, beef,
eggs, kidney) is recommended.
1. Jaros J, Katta R, Shi VY. Dermatonutrigenomics: Past, Present, and Future. Department of Dermatology, McGovern Medical School, UT Texas, Bellaire, TX,
USA. 2019
2. Cassano N, Vestita M, Apruzzi D, Vena GA. Alcohol, psoriasis, liver disease, and anti-psoriasis drugs. Int J Dermatol 2011;50:1323–1331.
3. Wolters M. Diet and psoriasis: experimental data and clinical evidence. Br J Dermatol 2005; 153:706–714.
Mustifah EF, Hastuti R, Sari ARP, Mulianto N. Peran Diet
pada Tatalaksana Psoriasis. J Continuing Professional
Development. 2017; 44 (10).
CONCLUSION
Diet is a habit that is allowed in terms of food and
drinks that a person eats from day to day, especially
those specifically designed to achieve the goal and to
enter or remove certain food ingredients .
The body's metabolic balance can be supplied with the materials

needed
Dietary intervention may be recommended as therapy, as in

dermatology cases.
Vitamin and minerals, necessary for me achieve skin healthy by

providing supplements that are good for the body.
THANK YOU

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REFERAT

Diet is related to one's body

02 VITAMIN B Complex (Biotin, B-6, B-12,

Vitamin A cannot be synthesized; it must be obtained through the

Vitamin A, also called retinol, is associated with intracellular

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

Other forms of vitamin C

Recommended Dietary Allowances (RDAs) for

Vitamin D has other roles in the body, including modulation of

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

Your Picture Here

1. Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

Selenium is important for reproduction, thyroid gland function,

Danby FW. Nutrition and acne. Clin Dermatol.2010; 28(6):598–604.

A 2008 Cochrane review assessed food

Smith et al published 4 intervention studies examining the effects of a low GI / GL diet

study on 4273 boys, self-reported

Animal studies have shown that the intake of fatty foods

Consumption of fresh fruit and vegetables, such as carrots, tomatoes, broccoli,

The body's metabolic balance can be supplied with the materials

Dietary intervention may be recommended as therapy, as in

Vitamin and minerals, necessary for me achieve skin healthy by

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