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CELIAC DESEASE
Celiac Desease
Celiac disease is a digestive disease that damages the
small intestine and interferes with absorption of
nutrients from food. People who have celiac disease
cannot tolerate a protein called gluten, which is found
in wheat, rye, and barley. When people with celiac
disease eat foods containing gluten, their immune
system responds by damaging the small intestine.
Specifically, tiny fingerlike protrusions, called villi, on
the lining of the small intestine are lost. Nutrients from
food are absorbed into the bloodstream through these
villi. Without villi, a person becomes malnourished--
regardless of the quantity of food eaten.
Sign and Symptoms of Celiac
Disease
Can begin at any age
Will persist for life
Can involve and affect multiple organs
May have varied symptoms or no symptoms
at all
Will always disappear once the patient
follows a gluten-free diet
Digestive Symptoms
Diarrhea
Abdominal Pain
Abdominal Bloating
Pale stool
Foul-smelling stool
Flatulence
Pallor
Weakness
Behavioral Symptoms
Depression
Irritabilityparticularly in children
Inadequate Nutrition
Symptoms
Weight Loss
Delayed growth
Failure to thrive
Anemia
Fatigue
Missed Menstrual periods
Unclassified symptoms
Gas
Bone pain
Joint pain
Seizures
Muscle Cramps
No symptoms
Ambiguous symptoms
Ambiguous symptoms
Tingling (in the legs from nerve damage)
Numbness (in the legs from nerve damage)
Mouth sores
Skin Rash
Dermatitis Herpetiformis
Tooth discoloration and enamel loss
Miscarriages
POSSIBLE COMPLICATION:
Damage to the small intestines and the
resulting problems with nutrient absorption
put a person with celiac disease at risk for
several diseases and health problems.
Lymphoma and adenocarcinoma are types
of cancer that can develop in the intestine.
Osteoporosis is a condition in which the
bones become weak, brittle, and prone to
breaking. Poor calcium absorption is a
contributing factor to osteoporosis.
Miscarriage and congenital malformation of the
baby, such as neural tube defects, are risks for
untreated pregnant women with celiac disease
because of malabsorption of nutrients.
Short stature results when childhood celiac disease
prevents nutrient absorption during the years when
nutrition is critical to a child's normal growth and
development. Children who are diagnosed and
treated before their growth stops may have a catch-
up period.
Seizures, or convulsions, result from inadequate
absorption of folic acid. Lack of folic acid causes
calcium deposits, called calcifications, to form in the
brain, which in turn cause seizures.
EXPECTED OUTCOME:
Research is needed to obtain data for
recommendations on the age at which to begin
screening, and the frequency of repeat screening,
of asymptomatic at-risk individuals. Additional
research is required to determine whether
serologic tests in specific clinical settings are
sufficient to confirm the diagnosis of celiac disease
without the need for a biopsy. Most cases with
positive EMA and TG2 autoantibodies have celiac
disease with a manifest gluten-dependent
mucosal lesion, and are DQ2- or DQ8-positive.
In future, a diagnosis of genetic gluten
intolerance may include patients with gluten-
dependent symptoms or signs of celiac disease,
a positive test for the autoantibodies, and the
correct celiac-type HLA DQ type, even though
they have an equivocal or normal small
intestinal mucosa on biopsy. A multicenter
study within the Federation of International
Societies for Pediatric Gastroenterology,
Hepatology and Nutrition.should determine the
natural history of celiac disease in such patients
who choose to remain untreated.
This study could provide the experimental
basis for new diagnostic criteria that combine
autoantibody positivity with correct genetics
without the need for invasive small intestinal
biopsy. However, while it is important to
diagnose celiac disease correctly, it is equally
important to avoid a false-positive diagnosis
and unnecessary treatment with a gluten-free
diet.
NURSING RESPONSIBILITIES
-Prepared the client for the diagnostic test
-Explain the procedure of the diagnostic test
-Assist the patient
Assesment and Diagnostic
Findings
Blood tests for four different antibodies. The
antibodies are IgA endomysial antibodies (EMA),
IgA tissue tranglutaminase (tTG), IgG tissue
transglutaminase, and total IgA antibodies.