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Statistical analysis

R Core Team (2014). R: A language and environment for statistical computing. R Foundation for
Statistical Computing, Vienna, Austria. URL http://www.R-project.org/.

Data collection

Shapiro Wilk <50 Normality analysis ? Kolmogorov Smirnof >50

Parametric Test Non Parametric Test

ANOVA Test of outlayer

▪ Kruskal-Wallis ▪ Dunn´s
Berlanga, V., & Rubio Hurtado, M. J. (2012) ▪ Friedman ▪ Holm-Sidak 1
• Physical and
neurological
Intervention design Consults examination
• Review of diary
• Blood test
Start of
protocol
2nd line of Tx
Randomize
1st line of Tx 1st line of Tx VPA+CLB+Stiripentol
d
Max. doses
VPA+CLB VPA+CLB+CBD
VPA+CLB
SD Indetermined Indetermined 4 previous
VPA+CLB+CBD+THC
period period weeks
Indetermined period

Weeks EEG
1 week 2 week 3 Week 4 Week
QVEE-50
# Sz # Sz # SZ # SZ

10
11
12
13
14
15
16
1`
2
3
4
5
6
7
8
9
• Invitation of protocol
• Informed consent • EEG
• Training of Diary • QVCE-50

Consults Consults Consults

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