TRANSPORT OKSIGEN

OLEH SISTEM
PERNAFASAN
Sri Redjeki Prasetyo
Dept. of Biomedical Sciences
Fac. Of Medicine Universitas Kristen Indonesia
Topics
1) Functions of respiratory passage ways
2) Mechanics of pulmonary ventilation (movement of air)
3) Respiratory volumes
4) Physical principles of gas exchange
5) Transport of oxygen and carbon dioxide in blood and tissue fluids
6) Regulation of respiration
1) Functions of Respiratory Passage ways
2) Mechanics of Pulmonary Ventilation
Inspiration Expiration
Thoracic cavity
Movement of air
3) Respiratory Volumes
Lung volume
4) Physical Principles of Gas Exchange
 Gas exchange

Types of trans membrane transport:

simple diffusion

Factors:
• Partial pressure difference of the gas
• Distance (membrane thickness)
• Surface area of the membrane
• Diffusion coefficient of the gas in the
substance of the membrane
5) Transport of Oxygen and Carbon Dioxide in Blood and Tissue fluids
The role of RBC (hemoglobin) – 97% O 2
Oxygen-Hemoglobin dissociation curve
Key concept
Compared with CO2 affinity of O2 is lower
• what is the consequence of the fact on the transport of both gases in
lung capillaries and tissue capillaries?

Increased H+ would decrease oxygen affinity with hemoglobin.

• Does the fact have physiologic function?
6) Regulation of Respiration

Nervous system adjusts the rate of alveolar ventilation:

PO2 and PCO2 in arterial blood are hardly altered even in heavy exercise

Adjustment of respiratory rate (frequency) and respiratory volume

Respiratory center

Dorsal respiratory group: basic

rhythm

Pneumotaxic center: limit

inspiration – increase rate of
breathing

Ventral respiratory group: heavy

respiration
Chemical control: H+
Peripheral chemoreceptors
Reference
• Guyton and Hall. Textbook of Medical Physiology 12th ed. 2011.
Saunders Elsevier
 TERIMA KASIH

TASK
1. Define:
lung ventilation (the formula/rumus)
Alveolar ventilation (the formula/rumus)
2. What is Hering – Breuer reflex? Define: the receptor – afferent –
integrating center – efferent – effector.