DRY

EYES
 Gland of Krause and Wolfring
Menghasilkan air mata

Meibomian Gland
menghasilkan oil untuk mencegah
evaporasi air mata

Gland of Zeis
menghasilkan oil pada bulu mata
 Tear Flow

Air mata di hasilkan oleh lacrimal gland

Saat berkedip air mata akan di

distribusikan ke permukaan
mata
Drainase air mata berawal
dari punctum

Lalu berlanjut kepada lacrimal sac dan

akhirnya tiba pada nasolacrimal duct

Air mata akan menguap atau di

absorbsi kembali
 Tear Film
Mucous/Mucin Layer
Mengikat air mata pada
permukaan mata

Aqueous Layer
Melindungi kornea
Merehidrasi mata
Melindungi dari bakteri

Lipid Layer
Mencegah evaporasi
DRY EYE SYNDROME

Banyak terjadi pada:

• usia tua
(perubahan hormonal)
•post menopause
(perubahan hormonal)
• pengguna contact lens
• Penyakit autoimun
DRY EYE SYNDROME

Low Production

Meibom Gland
Dysfunction
 DRY EYE SYNDROME

Low Production

Hyperosmolarity Inflamasi Kerusakan sel

Goblet

Meibom Gland
Dysfunction
Lacrimomimetics
 TBUT

Hasil TBUT terbaik

pada SH 0,3%

In Cheon Y, Ying L, Rujun J, Min A, Won C, Kyung C. Comparison of 0.1%, 0.18%, and 0.3% hyaluronic acid eye drops
in the treatment of experimental dry eye. Journal of Ocular Pharmacology and
Therapeutics.2018.doi:10.1089/jop.2018.0032
 APOPTOSIS

Apoptosis atau
kematian sel
paling kecil terjadi
pada SH 0,3%

In Cheon Y, Ying L, Rujun J, Min A, Won C, Kyung C. Comparison of 0.1%, 0.18%, and 0.3% hyaluronic acid eye drops
in the treatment of experimental dry eye. Journal of Ocular Pharmacology and
Therapeutics.2018.doi:10.1089/jop.2018.0032
 CORNEAL STAINING

Kerusakan
kornea paling
kecil terjadi
pada SH 0,3%
In Cheon Y, Ying L, Rujun J, Min A, Won C, Kyung C. Comparison of 0.1%, 0.18%, and 0.3% hyaluronic acid eye drops
in the treatment of experimental dry eye. Journal of Ocular Pharmacology and
Therapeutics.2018.doi:10.1089/jop.2018.0032
 Polyethylene Glycol

Kerusakan pada kornea dan

konjungtiva dapat mengakibatkan
PEG mengurangi squamous
kehilangan sel goblet 
metaplasia
squamous metaplasia

Alejandro A, Martin B, Jorge T, Alejandro B. Efficacy of polyethylene glycol-propylene glycol based lubricant
eye drops in reducing squamous metaplasia in patients with dry eyes. Clinical Ophthalmology. 2018.
 Polyethylene Glycol

Corneal Staining score

menurun setelah 90 hari
dengan pemberian
PEG

Alejandro A, Martin B, Jorge T, Alejandro B. Efficacy of polyethylene glycol-propylene glycol based lubricant
eye drops in reducing squamous metaplasia in patients with dry eyes. Clinical Ophthalmology. 2018.
 Polyethylene Glycol

Derajat kerusakan sel goblet

menurun

Alejandro A, Martin B, Jorge T, Alejandro B. Efficacy of polyethylene glycol-propylene glycol based lubricant
eye drops in reducing squamous metaplasia in patients with dry eyes. Clinical Ophthalmology. 2018.
THANKYOU