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Nervous System
Master control and communication system
Nervous System: Functions
Three overlapping functions
– Sensory receptors monitor changes inside and
outside the body
Change – a stimulus
Gathered information – sensory input
– CNS Processes and interprets sensory input
Makes decisions – integration
Integration
– interpretation of sensory
signals within processing
centers
Motor output
– conduction of signals to
effector cells (i.e. muscles,
gland cells)
The Nervous System
• Components
– Brain, spinal cord, nerves, sensory receptors
• Responsible for
– Sensory perceptions, mental activities,
stimulating muscle movements, secretions of
many glands
• Subdivisions
– Central nervous system (CNS)
– Peripheral nervous system (PNS)
Central Nervous System
• Consists of
– Brain
– Spinal cord
• Brain and spinal
cord
– Continuous with
each other
Peripheral Nervous System
• Two subcategories
– Sensory or afferent
– Motor or efferent
• Divisions
– Somatic nervous
system
– Autonomic nervous
system (ANS)
» Sympathetic
» Parasympathetic
Basic Divisions of the Nervous
System: PNS
Peripheral nervous
system (PNS)
– Outside the CNS
– Nerves extending
from brain and spinal
cord
Cranial nerves
Spinal nerves
– Link all regions of the
body to the CNS
Nervous System Organization
Sensory Input and Motor
Output
Sensory signals picked up by sensory
receptors
– Carried by afferent nerve fibers of PNS to the
CNS
Motor signals are carried away from the CNS
– Carried by efferent nerve fibers of PNS to
effectors
– Innervate muscles and glands
Sensory Input and Motor
Output
Divided according to region they serve
– Somatic body region
– Visceral body region
Results in four main subdivisions
– Somatic sensory
– Visceral sensory
– Somatic motor
– Visceral motor
Somatic Sensory
Somatic sensory
– General somatic senses – receptors are widely
spread
Touch, pain, vibration, pressure, and temperature
Proprioceptive senses – detect stretch in tendons and
muscle
Body sense – position and movement of body in
space
– Special somatic senses
Hearing, balance, vision, and smell
Visceral Sensory
Visceral sensory
– General visceral senses – stretch, pain,
temperature, nausea, and hunger
Widely felt in digestive and urinary tracts,
reproductive organs
– Special visceral senses – taste
Somatic Motor
Somatic motor
– General somatic motor – signals contraction of
skeletal muscles
Under voluntary control
Often called “voluntary nervous system”
Visceral Motor
Visceral motor
– Regulates the contraction of smooth and
cardiac muscle and gland secretion
– Makes up autonomic nervous system
– Controls function of visceral organs
– Often called “involuntary nervous system”
Peripheral Nervous System
Summary
Figure 12.3
Types of Sensory and Motor
Information
Figure 12.3
Types of Sensory and Motor
Information
Figure 12.3
Nervous Tissue
• Cell Body
• Dendrites
• Axon
• Presynaptic Terminals
Each region is specialized
for its particular function
Information flows in a single
direction
The Cell Body or Soma (also
called Perikaryon)
– Size varies from 5–140µm
– Contains nucleus, organelles plus other
structures
Chromatophilic bodies (Nissl bodies)
– Clusters of rough ER and free ribosomes
– Stain darkly and renew membranes of the cell
Neurofibrils – bundles of intermediate filaments
– Form a network between chromatophilic bodies
Nissl Body Staining
The Cell Body
Most neuronal cell bodies
– Located within the CNS (clustered in nuclei)
– Protected by bones of the skull and vertebral
column
Ganglia – clusters of cell bodies in PNS
Cell Body Structure
Figure 12.4
Neuron Cell Body Location
Extensions
outside the cell
body
Dendrites –
conduct
impulses toward
the cell body
Axons – conduct
impulses away
from the cell
body (only 1!)
Dendrites of Motor Neurons
• Short, tapering, and
diffusely branched
processes
• They are the
receptive, or input,
regions of the
neuron
• Electrical signals
are conveyed as
graded potentials
(not action
potentials)
Neuron Processes: Dendrites
Dendrites
– Extensively branching from
the cell body
– Transmit electrical signals
(graded potentials) toward
the cell body
– Chromatophilic bodies – only
extend into the basal part of
dendrites
– Function as receptive sites
Dendritic Spines
• Slender processes of Axons: Structure
uniform diameter arising
from the hillock
• Long axons are called
nerve fibers
• Usually there is only one
unbranched axon per
neuron
• Rare branches, if present,
are called axon collaterals
• Axonal terminal –
branched terminus of an
axon
Neuron Processes: Axons
Axons
– Neurofilaments, actin
microfilaments, and
microtubules
Provide strength along
length of axon
Aid in the transport of
substances to and
from the cell body
– Axonal transport
Neuron Processes
Axons
– Branches along length are
infrequent
– Multiple branches at end of axon
Terminal branches (telodendria)
– End in knobs called axon
terminals (also called end
bulbs or boutons)
Neuron Structure
Neuron Nerve
Processes:
impulse (action Action
potential)
–Potentials
Generated at the initial segment of the
axon
– Conducted along the axon
– Releases neurotransmitters at axon
terminals
– Neurotransmitters – excite or inhibit
neurons
– Neuron receives and sends signals
Axons: Function
• Generate and
transmit action
potentials
• Secrete
neurotransmitters
from the axonal
terminals
• Whitish, fatty Myelin Sheath
(protein-lipid),
segmented sheath
around most long
axons
• It functions in:
– Protection of the axon
– Electrically insulating
fibers from one
another
– Increasing the speed of
nerve impulse
transmission
Myelin
• CNS: oligodendroglia
or oligodendrocytes
Formation of myelin
sheath in cns.
Figure 12.15b
Myelin Sheaths in the PNS –
unmyelinated axons
Figure 12.15b
Myelin Sheaths in the CNS
Oligodendrocytes form
the myelin sheaths in
the CNS
– Have multiple processes
– Coil around several
different axons
Nodes of Ranvier
• Gaps in the
myelin sheath
between
adjacent
Schwann cells
• They are the
sites where
collaterals can
emerge
• Saltatory
conduction
Myelin Sheath and Neurilemma: Formation
• Formed by Schwann cells in the PNS
• A Schwann cell:
– Envelopes an axon in a trough
– Encloses the axon with its plasma membrane
– Concentric layers of membrane make up the myelin
sheath
• Neurilemma – remaining nucleus and cytoplasm
of a Schwann cell
Myelin
Sheath and
Neurilemma:
Formation
Figure 11.5a-d
Unmyelinated Axons
• A Schwann cell surrounds nerve fibers but
coiling does not take place
• Schwann cells partially enclose 15 or more axons
Axons of the CNS
• Both myelinated and unmyelinated fibers are
present
• Myelin sheaths are formed by oligodendrocytes
• Nodes of Ranvier are widely spaced
• There is no neurilemma
Terminal Ending
Synapses
Site at which neurons communicate
Signals pass across synapse in one direction
Presynaptic neuron
– Conducts signal toward a synapse
Postsynaptic neuron
– Transmits electrical activity away from a
synapse
Two Neurons Communicating
at a Synapse
Figure 12.6
Classification of Neurons
Structural Classification
Functional Classification
Structural Classification of
Neurons
Classification based on number of processes
– Multipolar
– Bipolar
– Unipolar (pseudounipolar)
By Neurite Shape or Number
(axons and dendrites)
Figure 12.10a–c
Bipolar Neurons
Figure 12.10a–c
Unipolar (Pseudounipolar)
Neurons
Figure 12.10a–c
Functional Classification of
Neurons
Classification based on direction of action
potential propagation
– Afferents –– from CNS to periphery
– Efferents from periphery to CNS
– Interneurons – within CNS
Afferent neurons
Afferent (sensory) neurons –
transmit impulses toward the CNS
– Virtually all are pseudounipolar neurons (some
true bipolar)
– Cell bodies in ganglia outside the CNS
Short, single process divides into
– The central process – runs centrally into the
CNS
– The peripheral process – extends peripherally to
the receptors
Periphery CNS
Afferent Neurons
Axon terminals
Sensory receptors
Functional Classification of
Neurons
Sensory (afferent) neurons
Carry impulses from the sensory receptors
Cutaneous sense organs
Proprioceptors – detect stretch or tension
Figure 12.11
Functional Classification of
Neurons
Sensory Motor
Interneuron
Neuron Classification
2. Classification and Function of Nerve
Fibers
•Function: conducting action potential
1)Characteristic
insulation,
two direction
no fatigue
2). Conducting velocities of AP propagation:
0.5~120m/s.
The factors that influence the AP propagation:
~The diameter of NF: 0.2 -20 mm, The larger the
diameter is , The faster A.P. propagates.
~ Myelin sheath:
~Temperature:
3). The general classification of NF
Electrical physiological classification (efferent
nerve): A, A, A, A; B, C.
Morphological classification (afferent nerve): I,
II, III, IV.
Neuron Internal Structure
Common structures
Organelles – smaller parts of
the cell with specific funtions
Cell membrane – acts as a
gatekeeper
Cytoplasm
Organelles are surrounded by a
jelly like substance
Primary component is water
Nucleus
Largest and most identifiable
part of the cell
Nucleus
Brain of the cell
Site of much of the
manipulation done in
biotechnology
Nucleus
Controls activity of the cell
Round or oval structure
Typically found in the middle of
the cell
Appears darker than
surrounding material
Nucleus
Surrounded by a membrane that
controls passage of materials in
and out of the area
Nucleus
Contains DNA
DNA is located on
chromosomes
Most organisms are diploid –
have tow chromosomes for each
trait
Other organelles
Ribosomes
Mitochondria
Golgibodies
Endoplasmic reticulum
Cytoplasmic
Organelles
Organelles are required for proper
cell function
Ribosome – make proteins for
cellular use and communication
May be attached to endoplasmic
reticulum
Endomembrane System
Endomembrane system
-a series of membranes throughout the
cytoplasm
-divides cell into compartments where different
cellular functions occur
1. endoplasmic reticulum
2. Golgi apparatus
3. lysosomes
90
Endoplasmic
reticulum
Layeredmembraneous
Make and transport proteins
Endomembrane System
Rough endoplasmic reticulum (RER)
-membranes that create a network of
channels throughout the cytoplasm
-attachment of ribosomes to the membrane
gives a rough appearance
-synthesis of proteins to be secreted, sent to
lysosomes or plasma membrane
92
Endomembrane System
Smooth endoplasmic reticulum (SER)
-relatively few ribosomes attached
-functions:
-synthesis of membrane lipids
-calcium storage
-detoxification of foreign substances
93
Smooth & Rough Endoplasmic
Reticulum
Smooth ER lacks
ribosomes &
makes proteins
USED In the cell
Rough ER has
ribosomes on its
surface & makes
proteins to
EXPORT
Endomembrane System
95
Lysosome
Contain digestive
enzymes
Break down food and
worn out cell parts for
cells
Programmed for cell
death (lyse & release
enzymes to break down
& recycle cell parts)
Vacuole
Large organelle, without
specific shape
Store waste or raw materials
used in synthesis of proteins
Golgi Bodies
Stacks of flattened
sacs
Have a shipping side
& a receiving side
Receive & modify
proteins made by ER
Transport vesicles
with modified proteins
pinch off the ends Transport
vesicle
Golgi Bodies
Golgi apparatus
Similar to endo. Ret.
Look like a thick elastic band
that has been folded several
times
Golgi Bodies
Adds modifications to
unfinished proteins
Makes lysosomes
101
Lysosome
Small round
Store enzymes that break down
food into chemical compounds
Destroy cell organelles and the
cell itself
Eukaryotic Cells
Ribosomes
-the site of protein synthesis in the cell
-composed of ribosomal RNA and proteins
-found within the cytosol of the cytoplasm
and attached to internal membranes
103
Mitochondria
Energy factories
Rod shaped
Change food into molecules
that can be used for energy
Mitochondria
Contain DNA
Can replicate themselves
Mitochondria
-surrounded by 2 membranes
-smooth outer membrane
-folded inner membrane with layers called
cristae
-matrix is within the inner membrane
-intermembrane space is located between the
two membranes
-contain their own DNA
106
Mitochondria
107
Cytoskeleton
Cytoskeleton
-network of protein fibers found in all
eukaryotic cells
-supports the shape of the cell
-keeps organelles in fixed locations
-helps move materials within the cell
108
The soma
– Nucleus
Gene expression
– Rough Endoplasmic reticulum (ER)
Major site for protein synthesis
– Ribosomes
– Smooth ER and Golgi Apparatus
Sites for preparing/sorting proteins for
delivery to different cell regions
(trafficking) and regulating substances
– Mitochondria
Site of cellular respiration (inhale and
exhale)
Krebs cycle
ATP- cell’s energy source
– Lysosomes
Glial Cells (Supporting Cells)
Six types of glial cells
– Four in the CNS
– Two in the PNS
Provide supportive functions for neurons
Cover nonsynaptic regions of the neurons
Supporting Cells (Neuroglial
Cells) in the CNS
Neuroglia – usually only refers to
supporting cells in the CNS, but can be used
for PNS
– Glial cells have branching processes and a
central cell body
– Outnumber neurons 10 to 1
– Make up half the mass of the brain
– Can divide throughout life
Types
Astrocytes
of Glial Cells in the
Microglia CNS
Ependymal Cells
Oligodendrocytes
Astrocytes
– Astrocytes – most abundant glial cell type
Take up and release ions to control the environment
around neurons
Recapture and recycle neurotransmitters
neural tissue
Produce molecules necessary for neural growth
(BDTF)
Propagate calcium signals that may be involved in
memory
Astrocytes
Figure 12.12a
Microglia
Microglia – smallest and
least abundant
Phagocytes –
the macrophages
of the CNS
Engulf invading
microorganisms and dead
neurons
Derived from blood cells
called monocytes
Figure 12.12b
Ependymal Cells
– Ependymal cells
Line the central cavity of the spinal cord and brain
Figure 12.13
Oligodendrocytes
Nerves
Nerves – cordlike organs in the PNS
Consists of numerous axons wrapped in
connective tissue
Axon is surrounded by Schwann cells
Nerves
Endoneurium – layer of
delicate connective tissue
surrounding the axon
Nerve fascicles – groups of
axons bound into bundles
Perineurium – connective tissue
wrapping surrounding a nerve
fascicle
Epineurium – whole nerve is
surrounded by tough fibrous
sheath
Simplified Design of the
Nervous
Sensory neurons System
– located dorsally
– Cell bodies outside the CNS in sensory ganglia
– Central processes enter dorsal aspect of the spinal
cord
Motor neurons – located ventrally
– Axons exit the ventral aspect of the spinal cord
Interneurons – located centrally
– Provide communication between sensory and
motor neurons and between levels of the CNS
Gray versus White Matter in
Gray matter
the Central Nervous
– Cell bodies
•White matter
System
•Axons (myelin)
– Dendrites
– Synapses
Gray
Matter in the
Gray matter in the spinal cord
Spinal Cord
– H-shaped (butterfly) region – surrounds central cavity
– Dorsal half contains cell bodies of interneurons
– Ventral half contains cell bodies of motor neurons
– Cell bodies are clustered in the gray matter
White Matter in the Spinal
White matter in the spinal cord
Cord
– Located externally to the gray matter
– Contains no neuronal cell bodies, but millions of
axons
– Myelin sheath – white color
Consists of axons running between different parts of
the CNS
Tracts – bundles of axons traveling to similar
destinations
CortexGray Matter
and nuclei in Brain
White
Pathways, Matter
tracts in Brain
and commissures
Types of Synapses
Axodendritic
– Between axon terminals of one neuron and dendrites
of another
– Most common type of synapse
Axosomatic
– Between axons and neuronal cell bodies
Axoaxonic, dendrodendritic, and dendrosomatic
– Less common types of synapses
– Function not as well understood
Types of Synapses
Figure 12.7
Synapses
Axodendritic synapses – representative type
Synaptic vesicles on presynaptic side
– Membrane-bound sacs containing neurotransmitters
– Mitochondria abundant in axon terminals
Synaptic cleft separates the plasma membrane of
the two neurons
Structure of a Synapses
PLAY Synapse
Figure 12.8a, b
Synapse
4) Axoplasmic transport
The concept: Various organelles and materials must
be moved from the cell body, where they are made, to
the axon and its terminals in order to maintain the
structure and function of the cell axon.
The mechanisms: Cytoskeletal filaments in the
axon and cell body, which serve as the rails along
which the transport occurs, are linked by proteins to
the substances and organelles being moved.
Anterograde axoplasmic transport
~ fast axoplasmic transport: 410mm/day,
mitochondria, vesicles, secretory granule.
~ slow axoplasmic transport:1-12 mm/d, cytoskeletal
elements & soluble proteins
Retrograde axoplasmic transport : Axon
transport of certain materials are from the axon
terminals to the cell body. 205mm/d,
Fig. Axopasmic transport
II Supporting Cells: Neuroglia
Ependymlal
Cell
Microglia
Oligod
endro
cyte Astrocyte
• Astrocytes
– Regulate extracellular brain fluid composition
– Promote tight junctions to form blood-brain barrier
• Ependymal Cells
– Line brain ventricles and spinal cord central canal
– Help form choroid plexuses that secrete cerebrospinal fluid (CSF)
Neuroglia of CNS
• Microglia
– Specialized macrophages
• Oligodendrocytes
– Form myelin sheaths if surround axon
Neuroglia of PNS