Subclinical Endometritis threatens

the success rate of embryo transfer.

Impact on donor cows
Subclinical Endometritis causes an unpleasant
environment in the endometrium and lowers the
amount of fertilized ova and viable embryos.

Impact on receiving cows

The embryo survival in an inflamed uterus of
cows suffering from Subclinical Endometritis
is significantly lower.
Subclinical Endometritis Detection
with Oculyze Monitoring Uterine Health (MUH)

3 out of 10 Undetected

cows suffer from as there are no typical

Subclinical Endometritis uterus infection symptoms
 Embryo transfer brings efficient breeding to the next level -
we can help to ensure consistent results

Direct on-farm Results Zero laboratory

detection within minutes knowledge needed
 Step 1
take endometrial sample and streak
sample on slide

How it works Step 2

Stain the sample with two drops of
fluorescent dye
Oculyze Monitoring Uterine Health is a quick and easy tool to
detect Subclinical Endometritis through automatically Step 3
identifying inflammatory cells (PMNs).
connect the microscope with your
mobile device
With Oculyze you can turn your smartphone or tablet into a
powerful on-farm laboratory by simply connecting it to our Step 4
mobile fluorescence microscope.
take as many images as you need to
capture about 300 cells

Step 5
immediately review analysis results
directly in the app
Inflammatory cell detection
The Monitoring Uterine Health (MUH)
system is counting and classifying
mucosal- and polymorph nucleus cells
(PMN) in your samples.  and 100% reproducible no matter who is
The results consist of the total number
of cells, the amount of inflammatory
cells (PMNs) and the relation between
the two (%).
With the results you will be able to
quickly detect cows who suffer from
subclinical or cytological endometritis
to implement adequate measures.
Reliable results, every time
The app has built in tools which make it
easy to use with minimal training. The
actual analysis is made by an algorithm
using the device.
Our sharpness indicator and brightness
controller helps you to capture sharp
and contrasting images for the PMN
analysis even if you have never handled
a microscope before.  analyses at any time, from anywhere.
The app will also give you a warning if it
detects any inconsistencies during the
analysis due to unfit samples.
Automated documentation
In app you can add custom tags such as
ear tag numbers to your analyses. This
helps you structure and sort your results
and support your workflows in the best
way possible.
The entire documentation will be gene-
rated automatically and uploaded to our
cloud system. This enables you to get
access to your complete history of
Using our web app will also allow you to
export all your data in a CSV file or
generate custom reports as a PDF
document.
Ensure a consistent breeding
process and prevent poor
conception rates.
For more information, please reach out to us. We are happy to
provide you more insights on Subclinical Endometritis and how
Oculyze can help to detect it to avoid its consequences.

Oculyze Monitoring Uterine Health (MUH) Prototype 2.0

References:

Ismael Fernandez-Sanchez, Monica Barrio-Lopez, Luis A. Quintela-Arias, Juan J. Becerra-Gonzalez, Ana I. Peña-Martinez, Daniel
Martinez-Bello, Pedro J. Garcia-Herradon and Carlos C. Perez-Marín.Use of endometrial cytology and metabolic profiles for selection of
embryo donor cows. Spanish Journal of Agricultural Research 2014 12(3): 664-671

Carvalho PD, Souza AH, Sartori R, Hackbart KS, Dresch AR, Vieira LM, Baruselli PS, Guenther JN, Fricke PM, Shaver RD, Wiltbank MC.
Effects of deep-horn AI on fertilization and embryo production in superovulated cows and heifers. Theriogenology. 2013
Dec;80(9):1074-81. doi: 10.1016/j.theriogenology.2013.08.008. Epub 2013 Sep 29. PMID: 24084230; PMCID: PMC5942213.

Drillich M, Tesfaye D, Rings F, Schellander K, Heuwieser W, Hoelker M. Effects of polymorphonuclear neutrophile infiltration into the
endometrial environment on embryonic development in superovulated cows. Theriogenology. 2012 Feb;77(3):570-8. doi:
10.1016/j.theriogenology.2011.08.033. Epub 2011 Nov 4. PMID: 22056012.

Hill J, Gilbert R. Reduced quality of bovine embryos cultured in media conditioned by exposure to an inflamed endometrium. Aust Vet J.
2008 Aug;86(8):312-6. doi: 10.1111/j.1751-0813.2008.00326.x. PMID: 18673472.