1

Sickle Cell
Anemia
Presented by:
LLANDINO, JOY DANIELLE F.
 2

What is Sickle
Cell Disease?
 3

A Sickle Cell Disease is…

• An inherited disease of red blood cells (erythrocytes)
• A disease that affects a protein inside the red blood cells called
hemoglobin.
• Sickle-shaped red cells that interrupts blood flow by blocking small
blood vessels.
• Where the tissue that has no blood flow can be damaged and can
cause pain.
 4

○ A person with sickle cell disease has one different

substance in the way it makes hemoglobin. This
What is Sickle
substance is the amino acid valine in one spot where
Cell Disease?
there should be glutamic acid.

○ This one change causes the chemical to form long

strings when it lets loose of its' oxygen. This causes
the red cell to become deformed into a "sickle"
shape.
 Anemia 5

Sickle Cell Normal Blood Cell

Abnormal Normal
Hemoglobin Hemoglobin

Sickle cells blocking blood flow

 6

o Sickle cell disease is a genetic disorder caused by

mutations in the beta globin gene that leads to faulty
hemoglobin protein, called hemoglobin S. Hemoglobin S
changes flexible red blood cells into rigid, sickle-shaped
cells. These sickle cells can block blood flow, and result in
pain and organ damage.
 7

Vision
Stroke
problems

Complications from
Sickle Cell Disease
Pain Acute
episodes Chest
syndrome

Swelling
Increased
of hands
infections
and feet
 8
Managing Sickle Cell
Fluids Antibiotics Pain Medication
1 3 5

2 4 6

Rest Prevention of Healthy lifestyle

infections