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C O R2
R1
CH3
CH3
HO OH
H R1 = OH or H
R2 = H or NHCH2COOH or NHCH2CH2SO3
C O R2
R1
CH3
CH3
HO OH
H R1 = OH or H
R2 = H or NHCH2COOH or NHCH2CH2SO3
H 2C O C R1 H 2C O C R1
O O O
HC O C R2
H 2O
HC O C R2
O C R3
O
H 2C O C R3 H 2C OH
R C O
Lipid-free
Apolipoprotein A-I
PDB 2A01
A strip of
hydrophobic
residues runs
along one edge of
the amphipathic
-helix. Lipid-binding domain of HDL Apolipoprotein A-I
receptor-mediated
endocytosis
elastic
lamina smooth muscle cells
Cell layers adjacent to the lumen of arterial blood vessel.
Development of an atherosclerotic plaque:
Various conditions can initiate formation of a lesion in the
endothelium lining the arterial lumen.
Inflammatory response, including cytokine production
that may be activated by oxidized lipids present in LDL.
Risk factors include elevated circulating LDL, high
blood pressure, exposure to nicotine, etc.
blood vessel lumen endothelial cells
elastic
lamina smooth muscle cells