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Dr Archna Ghildiyal
Associate Professor
Department of Physiology
KGMU
LECTURE:8
Contents
• Regulation of Respiration: Neural
• Group of Neurons controlling
Respiration
• Breathing rhythm: Ramp Signals
• Lung Receptors
Learning Objectives
• NeuralControl of Respiration :
- Automatic
-Voluntary
• I & E Neurones
• Inspiratory “Ramp” Signal
• Pre-Botzinger Complex
• Lung Receptors
Neural Control of Respiration
Breathing
• Automatic/Spontaneous
• Voluntary
Neural control of Respiration
Groups of Neurons in the Respiratory Center
In medulla
• Dorsal respiratory group
• Ventral respiratory group
In Pons
• Pneumotaxic center
• Apneustic Center?
Dorsal Respiratory Group(DRG)
Controls
• Inspiration
• Respiratory rhythm
Inspiratory “Ramp” Signals
• Rhythmical Inspiratory discharge from
DRG
• Nervous signal that is transmitted to the
inspiratory muscles, mainly the diaphragm
• Begins weakly & increases steadily for
about 2 secs in normal respiration
(inspiration)
• Then ceases abruptly for approx next 3
secs (expiration)
Control of Inspiratory Ramp
1.Control of the rate of increase of the ramp
signal rate of ramp signal - ramp
increases rapidly - fills the lungs rapidly
2.Control of the limiting point at which the
ramp suddenly ceases
• Usual method for controlling the rate of
respiration; shortens the duration of
Inspiration & Expiration(frequency of
respiration )
Contd…
• Chemoreceptors
• Pulmonary irritant receptors-on
stimulation cause
coughing,sneezing,bronchial
constriction
• Lung “J Receptors”
• Hering-Breuer inflation reflex
Lung “J Receptors”
• Indian Physiologist Prof A S Paintal
• Location:Sensory nerve endings in
alveolar walls in juxtaposition to pulmonary
capillaries
• Stimulus: Severe exercise, Engorged
capillaries,Pulmonary oedema
• Effect:Tachypnea,Hypotention,Bradycardia
J-Reflex
• Stimulation (severe exercise)
• Inhibition of gama motor neurons
supplying muscle spindle
• Muscle Tone
• Muscle Weakness & Stoppage of Exercise
Hering- Breuer Inflation Reflex
• Protective reflex
• Lung inflation signals limit inspiration
• Stretch Receptors: In Muscular Walls Of
Bronchi & Bronchioles
• Active when Tidal volume > 1.5 liters/breath
• Inspiratory ramp :“Switches off”
References
• John E. Hall.Guyton & Hall Text book of
Medical Physiology. A south Asian ed:
New Delhi: Elsevier.2013.p. 364-373
• Kim E. Barrett, Heddwen L. Brooks, Scott
Boitano, Susan M. Barman.ed:23rd
Ganong’s Review of Medical
Physiology:Mc Graw Hill
• http://meded.ucsd.edu/ifp/jwest/resp_phys/
student_files.html
Question:1
Respiratory control centers are
located in the :
A) Midbrain and Medulla
B) Medulla and Pons
C) Pons and Midbrain
D) Upper Spinal Cord and Medulla
Question:2
A) Stimulates ventilation
B) Inhibits ventilation
C) Stimulates inhalation but inhibits exhalation
(apneustic breathing)
D) Stimulates exhalation but inhibits inhalation
Question:4
Destruction of which part abolishes
automatic respiration?
A) Pre-Botzinger complex
B) Ventral group of respiratory neurons
C) Dorsal group of respiratory neurons
D) Section at the inferior border of the
pons
Question:5
Which of the following statement is true?
A) Hering Breuer inflation reflex respond to
lung distension by increasing frequency of
respiration.
B) Irritant receptors respond to noxious gases
by reflex bronchodilatation
C) J receptors respond to pulmonary capillary
congestion by rapid shallow breathing
D) DRG neurons initiate expiration
Answers
1-B
2-B
3- A
4- A
5-C