Professional Documents
Culture Documents
1
Learning objectives
2
Nervous system
PNS CNS
Somatic NS ANS
3
02/23/2022 3
Peripheral Nervous System -PNS
4
PNS….cont’d
6
Enteric nervous system
7
Comparison of SoNS VS. ANS
ANS
SoNS
1. Controls involuntary activities
1. Controls contraction of the
such as CVS, GIT, sweat glands
sk/muscle.
2. Nerve fibres are originated from
2. Nerve fibres are originated the lateral horn of the spinal
from the anterior horn of cord.
the spinal cord. 3. Autonomic fibres contain two
3. The motor nerve contains neurons( pre- and
single, long, thick and postganglionic)
myelinated axon. 4. There are both cholinergic and
4. The NT is always Ach and adrenergic fibres acting on
the receptor is always cholinergic and adrenergic
nAchR receptors
8
The Cranial Nerves-PSNS components
9
Cranial nerves (I-VI)
Nerve Name Sensory Motor Autonomic
Parasympathetic
I Olfactory Smell
II Optic vision
Pupillary constriction
4 Extrinsic Eye
III Oculomotor Proprioception Accommodation
muscles
Focusing
1 Extrinsic Eye
IV Trochlear Proprioception muscle
(Sup. Oblique)
Somatic senses
(Face, tongue),
V Trigeminal Chewing
corneal
sensitivity
1 Extrinsic Eye
VI Abducens Proprioception muscle
(Lateral rectus)
10
Cranial nerves (VII-XII)
Autonomic
Nerve Name Sensory Motor
Parasympathetic
Taste Muscles of facial Salivary glands
VII Facial
Proprioception expression Tear glands
Auditory
Hearing.&
VIII (Vestibulo
Balance
cochlear)
Glossopharyn Taste Swallowing
IX Salivary glands
geal Blood gases Gagging
Many visceral
Blood pressure
Speech organs
X Vagus Blood gases
Swallowing Gagging (heart, gut, lungs)
Taste
Neck muscles:
Spinal
XI Proprioception Sternocleidomastoid
accessory
Trapezius
Tongue muscles
XII Hypoglossal Proprioception
Speech 11
Cranial nerve ….. cont’d
Cranial Nerves Mediate 5 Special Senses: Smell, Vision,
Hearing, Taste, Equilibrium
Smell: CN-I (Olfactory)
Vision: CN- II (Optic)
Hearing: CN-VIII (Cochlear division)
Equilibrium: CN-VIII (vestibular division)
Taste: CNs -VII, IX, X (minor) (Facial, Glossopharyngeal,
Vagus respectively)
Most of the Nerves Carry Somatic (Skin & Muscle) Sense
The trigeminal (V) is the sensory nerve for the face &corneal
sensitivity.
The nerves which are primarily motor also have fibers for
muscle sense (proprioception): III, IV, VI, VII, XI, XII
12
Cranial nerve ….. cont’d
Three Nerves Are Concerned With Eyeball Movements
Oculomotor (III): superior rectus, medial rectus, inferior
rectus, inferior oblique
Trochlear (IV): superior oblique
Abducens (VI): lateral rectus
Several of the Nerves Innervate Skeletal Muscles
The Facial nerve (VII) controls muscles of facial expression
The Spinal accessory (XI) stimulates the trapezius and
sternocleidomastoid muscles
Chewing muscles (masseter, temporalis) are innervated by
the Trigeminal (V)
Speech muscles (larynx) are under the control of the Vagus
(X)
The Hypoglossal (XII) moves the tongue
13
Cranial nerve ….. cont’d
14
Spinal nerves
31 pairs of spinal nerves
All contain afferent and efferent
8 cervical
12 thoracic
5 lumbar
5 sacral
1 coccygeal
Afferent
Sensory receptors relay to CNS
Long part of the axon is found out side CNS
Afferent neurons are 1st order neurons
Efferent
Carry signals from CNS to muscles & glands
More complicated than the afferent division
15
Spinal nerves.….cont’d
16
Functions, properties and Organizations of ANS
Controls most visceral functions such as
Heart and lungs in thorax
Gastrointestinal, genital, urinary system in the abdomen
Orchestrates the continuous adjustments in
Respiration
Circulation
Digestion
Body temperature
Rapidity and intensity of changes on effectors functions
With in 3-5 seconds it doubles the heart rate
With in 10-15 sec it doubles the ABP
17
Functions of ANS….cont’d
Spinal cord
Brain stem
Hypothalamus
18
Functions of ANS….cont’d
Autonomic Nervous
System
Can be divided into:
Sympathetic Nervous
System
• “Fight or Flight”
Parasympathetic
Nervous System
• “Rest and Digest”
19
There are two neurons in the ANS :
• A preganglionic neuron
• Postganglionic neuron
CNS CNS
Preganglionic
Neuron
Sympathetic Parasympathetic
Ganglion Ach
Ach
Postganglionic Ganglion
20
Neuron
NA Ach
Effector
Anatomical Differences in Sympathetic and Parasympathetic
Divisions
l io n
Preganglionic fiber Autonomic ng
tga
ganglion Pos iber
f
Ach
Ach
Sympathetic pathway NE
ut o nomic Postganglion
A
on
Preganglionic gangli fiber
fiber
Ach Ach
Parasympathetic pathway
02/23/2022 21
21
Criteria for distinguishing between:
• Sympathetic
and
• Parasympathetic
22
Sympathetic division
Originates in lateral horns of T1-T12 and L1-L2 region of
spinal cord
Components of the Sympathetic neurons
1. Cell bodies of preganglionic motor neurons are located in
the thoracic and lumbar part of the spinal cord
2. Preganglionic axons synapse in lateral/collateral ganglia,
which are located near the spinal cord far away from the
organs being innervated
3. Contains short preganglionic neurons which are
cholinergic.
4.Sympathetic postganglionic axons travel from the
lateral/collateral ganglia to the target organ
5. Contains long postganglionic neurons
23
Sympathetic neurotransmitters
Pregangilnic – Ach
Postganglionic –NE, except sympathetics innervating sweat
glands, blood vessels in skeletal muscle, and piloerection muscles
are cholinergic.
Sympathetic outflow/ origin (Fig-1 )
T1 head
T2 neck
T3-T6 thorax
T7-T11 abdomen
T12, L1&L2 legs 24
02/23/2022
Sympathetic division….cont’d
25
Sympathetic division….cont’d
26
Sympathetic division….cont’d
Function:
Sympathetic mass discharge during emergency" situations (flight
or fight response)
Sympathetic mass discharge: simultaneous activation of various
organs
The sympathetic neurons have excitatory effects on almost all body
tissues. Their effect is excitatory on CVS and inhibitory on the GIT
Catabolic, increases MR and energy output
Tonic discharge of impulse to the heart and blood vessels
27
Two classes of adrenoceptors are distinguished
• - Receptors
• β - Receptors
Alpha receptors
Constriction of gastric intestinal and bladder sphincter
Vasoconstriction
Contraction of pupillary dilator
Beta receptors
Increase in cardiac rate and strength of contraction
Inhibition of gastric motility
28
02/23/2022 28
Stimulation of Sympathetic nerve to a Smooth Muscle
with Different Receptors
Smooth Muscle
Alpha receptor
Contraction
Beta receptor
Relaxation
02/23/2022 29 29
Parasympathetic Division
30
Parasympathetic Division… cont’d
31
Parasympathetic Division… cont’d
Components of the parasympathetic neurons
33
Parasypatatic neurotransmitter
• Both Pregangilnic and Postganglionic – Ach
Found at:
1. Postganglionic parasympathetic neuroeffector junctions
2. All autonomic ganglia
3. At the neuromuscular endplate
Types (Based on selective activation and antagonism)
1. Muscarinic receptors
2. Nicotinic receptors
34
Ach
Agonists
Curare Nicotine
Antagonists
Muscarine Atropine
02/23/2022 35
Summary Effector Organ
Nicotinic
α,β1 β2
receptor
receptors
Sympathetic
Preganglionic Postganglionic
ACh Noradrenaline
Effector Organ
Nicotinic Muscarinic
receptor receptors
Parasympathetic
Preganglionic Postganglionic
ACh ACh
02/23/2022 36
Summary Cont. Nicotinic
receptor
Adrenalin (80%)
Noradrenalin (20%)
Adrenal gland
ACh
Skeletal
muscle
Somatic
ACh
Nicotinic
receptor
02/23/2022 37
37
Autonomic ganglia
38
Major sympathetic ganglia and their effectors
39
39
Autonomic ganglia.....cont’d
40
Effects of ANS on various organs
41
Effects of ANS on various organs
42
Effects of Autonomic innervation
43
Clinical disorder of ANS
2. Excessive sweating
3. Disturbance of sexual functions
4. Pupillary and salivatory disturbances
44
Clinical disorder … cont’d
polyneuropathy)
Relatively rare condition
Both sympathetic and parasympathetic systems are
affected mainly at the postganglonic level.
Anhidrosis, hypotension, paralysis of pupillary reflexes.
Loss of lacrimation and salivation impotence,
45
Clinical disorder … cont’d
2. Excessive Sweating:
It is a sympathetically mediated disorder.
Its cause is not known
One variety, presumably of congenital origin, affects the
palms
46
3. Disturbances of Sexual Function:
Sexual function in the male:
Ejaculation
By sympathetic neuron.
47
02/23/2022 47
Assignment (presentation)
Reflex action g1
Autonomic reflexes
Component of reflex
The Baroreceptor reflex
The chemoreceptor reflex
Defecation reflex
Micturition reflex
Water and electrolyte balance g5
Water balance
Electrolyte balance
Special sense
Physiology of hearing and balance g 4
Physiology Vision g2
Physiology Taste
Physiology Smell g3
48
Thanks !
49