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PHYSICS OF TABLET
COMPRESSION AND
COMPACTION
UNNATI GARG
M. Pharm (Pharmaceutics)
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INTRODUCTION
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COMPACTION:
Compaction of a powder is a general term used to describe
a situation in which powdered material is subjected to some
level of mechanical force.
COMPRESSION:
Compression of a powder means reduction in the bulk
volume of a material as a result of displacement of the
gaseous phase under pressure.
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STAGES OF TABLET
COMPACTION Amity Institute of Pharmacy
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PHYSICS OF TABLET
COMPACTION Amity Institute of Pharmacy
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PARTICLE
REARRANGEMENT Amity Institute of Pharmacy
• Energy evolved
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DEFORMATION
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Elastic Deformation:
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Plastic Deformation:
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Brittle Fracture:
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BONDING OF
PARTICLES Amity Institute of Pharmacy
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EJECTION Amity Institute of Pharmacy
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FORCE
DISTRIBUTION Amity Institute of Pharmacy
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COMPACTION
EQUATION Amity Institute of Pharmacy
HECKEL EQUATION
The Heckel equation is based on the assumption that
densification of the bulk powder under force follows first-order
kinetics. It is expressed as:
𝟏
𝒍𝒐𝒈 = 𝒌𝒚 𝑷 + 𝒌𝑹
𝑬
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• The two regions of the Heckel plot are thought to represent the
initial repacking stage and the subsequent deformation
process, the point of intersection corresponding to the lowest
force at which a coherent tablet is formed.
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REFERNCES Amity Institute of Pharmacy
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