Professional Documents
Culture Documents
Hippocampus
Sensory Cortices
Somatic NS
Amygdala
Autonomic NS
Thalamus
Endocrine
Sensory Information
Fear Extinction
• Learning not to fear
– Presenting CS without US will lead to extinction
(gradual process)
– Important adaptation that can allow suppression of
previous fear
• New learning and not forgetting
– Context dependent – fear response can still occur
(renewal) in contexts different than where extinction
occurred
– Response of some LA neurons returns to normal after
extinction but others remain elevated
Fear Extinction
• Neural processes involved in extinction
• Less well understood
– Hippocampus (dorsal)
• Reversible inactivation (muscimal) eliminates contextual fear
renewal
• Hippocampus projects to amygdala (basal area) but this
does not explain effect
– Medial Prefrontal Cortex (mPFC)
• Lesions lead to more resistance to extinction
• Hippocampus projects to mPFC
• mPFC projects to LA
• mPFC suppresses fear to CS when in context where
extinction occurred
Amygdala and Fear in Humans
• Fear conditioning leads to amygdala activity
• More active during fear than anger or happiness
• Psychopaths (emotional detachment) show deficits in fear conditioning
(but no clear evidence yet of amygdala involvement)
• Emotional Preservation
– Failure of suppressing (extinguishing negative emotions)
– Can occur in depression, anxiety, fear (posttraumatic stress disorders)
disorders
– Amygdala is overactive (hyper) in these conditions and mPFC is under
active (hypo)
– Inverse relation between mPFC and amygdala activity
• Perception of Fear – Amygdala damage leads to deficits in emotional
(especially fear) facial and voice perceptions
Posttraumatic Stress
• Emotional reaction to extreme trauma
– Last longer than month (shorter is termed acute
stress)
– Comorbid disorders – depression, general anxiety,
substance abuse (sedatives [alcohol] are treatment
for anxiety)
• Diagnostic and Statistical Manual of Mental Disorders-IV
– the person experienced, witnessed, or was confronted
with an event or events that involved actual or
threatened death or serious injury, or a threat to the
physical integrity of self or others
– the person’s response involved intense fear,
helplessness, or horror
Posttraumatic Stress
• Symptoms
– Intrusions – nightmares & flashbacks
– Hyperarousal – startle response
– Avoidance – avoiding contact with
things/others
• Neural Signals
– Hyperactive amygdala
– Lower control from medial prefrontal cortex &
hippocampus
Depression
• Loss of motivation & interest in everyday
activities, pessimistic, etc.
• Important qualities that are low in
depression
– Control
– Self-esteem
• Instrumental Learning
– Learned helplessness – learning that your
actions do not affect outcomes
Depression
• Attributions
– Non-depressed
• Good things – internal cause
• Bad things – external cause
– Depressed
• Good things – external cause
• Bad things – internal cause
• Neural
– Serotonin & norepinephrine
• Tricyclics (Tofranil & Elavil) – block re-uptake of these NTs
• Monoamine Oxidiase Inhibitors, MAOIs (Narplan, Nardil, Parnate) –
block enzyme that destroys these NTs
• Selective Serotonin reuptake inhibitors, SSRIs (Prozac) – blocks re-
uptake of only serotonin
– Effectiveness suggests that serotonin may be the more important NT
Happiness
• Progress toward goals
– Assessment of our goals and progress toward
them
• More difficult to study in non-humans than
negative emotions
– Know less about happiness than negative
emotions (fear, anger, etc.)
Happiness
• Sensory Pleasure
– Pleasure arises from sensory feedback
• Sex
• Homeostasis – food, temperature, etc.
• Liking (opiate) and wanting (dopamine) brain
systems
– Stimuli that are useful are liked more and “consuming”
them leads to pleasure
Happiness
• Is happiness extension of Sensory Pleasure?
– Not clear
• More sensory pleasure does not equate to greater happiness
– Drugs that hijack these systems do not lead to greater
happiness
• Some evidence that lowering dopamine (e.g., drugs for
treating schizophrenia) reduce happiness
– Phasic vs. chronic levels of pleasure brain areas
might explain differences
• Phasic – brief spike in system that signals sensory pleasure
• Chronic – overall background levels that might be associated
with happiness
Happiness
• Individual/genetic differences in happiness
– Twin studies suggest sizable (perhaps 50%) of
happiness has genetic/biological roots
• Big 5 personality dimensions – Extroversion,
Agreeableness, Neuroticism, Openness,
Conscientiousness
– Higher Extroversion higher happiness
• Extrovert: tend to enjoy human interactions, are enthusiastic,
talkative, assertive, and gregarious, take pleasure in
activities that involve large social gatherings
• Introvert: tend to be quiet, low-key, deliberate, and relatively
non-engaged in social situations, take pleasure in solitary
activities such as reading, writing, watching movies, listening
to music, etc.
Happiness
• Big 5 personality dimensions
– Higher Agreeableness relates to higher
happiness
• Agreeable people are empathetic, considerate,
friendly, generous, helpful
• Believe that most people are honest, decent, and
trustworthy
• are more responsive to others than are their peers
– Lower Neuroticism higher happiness
• Tendency to experience negative emotions
(anxiety, fear, guilt, etc.)
Happiness
• Social Networks
– Quantity and quality of social networks important
– May help explain importance of big 5 (extroversion &
agreeableness)
– Secure attachment in children (parents that are sensitive,
responsive, consistent & supportive)
• Self-esteem
– Attitude our view of yourself
• Control
– Self-efficacy – belief that you have the ability to alter and affect
things in your life
– May help explain decreased overall happiness with pleasurable
stimuli (e.g., drugs) that involve loss of control
– Predictability important in absence of complete control
• Uncertainty lowers happiness
Happiness
• External
– Money
• only to a minimum amount – once people have
enough to meet basic life requirements more does
not increase happiness
– Music
• Powerful effects on mood (both happy and
unhappy)
Happiness
• Consequences
– Health
• Happiness influences immune function
– Rats (control/helplessness training) & cancer
– Stress & sickness
– Longevity