MALFUNCTION OF THE CELL CYCLE: DISORDERS AND DISEASES

INTRODUCTION TO
THE CELL CYCLE

• Brief overview of the cell

cycle (phases: interphase,
mitosis, and cytokinesis)
• Importance of proper cell
cycle regulation for normal
cell functioning
NORMAL Cancer is a result of uncontrolled
cell growth and division.
CELL CYCLE
PHASES
Down syndrome is caused by
abnormal cell division during
meiosis.

Alzheimer's disease is linked to

abnormal cell division in the
brain.
 Cancer is caused due to
CAUSES OF uncontrolled cell division.
CELL CYCLE
MALFUNCTION
Down Syndrome is caused
by an extra chromosome
during cell division.

Progeria is caused by a
genetic mutation during
DNA replication.
DISORDERS AND Cancer is the most common
DISEASES disease resulting from cell cycle
RESULTING FROM malfunction.
CELL CYCLE
MALFUNCTION Down Syndrome is a genetic
disorder caused by an extra
chromosome during the cell
division process.

Progeria is a rare genetic disorder

that causes premature aging due to
defective cell division.
GENETIC
DISORDERS
Genetic disorders like cancer,
Down syndrome, and sickle cell
anemia are caused by abnormal
cell division and replication
during the cell cycle.
PROGERIA
Is a genetic condition that
causes rapid aging in
children due to a specific
gene mutation. It affects
both their appearance and
health, leading to various
challenges.
Autoimmune Diseases

Occur when the immune

system attacks healthy
cells and tissues in the
body, resulting in chronic
inflammation and tissue
damage.
Methods of Studying
Cell Cycle Disorders
Studying Cell
Cycle Disorders
Understanding DNA
replication, regulation, and
repair mechanisms are crucial
to studying cell cycle
disorders. Advanced imaging
techniques are also used.
 Microscopy
Techniques
• Fluorescence microscopy is used
to visualize the cell cycle in living
cells.
• Confocal microscopy is used to
create detailed 3D images of cells.

• Electron microscopy is used to

visualize the ultrastructure of cells.
Flow Cytometry
• Flow cytometry is a method of
studying cell cycle and is used to
sort cells based on their physical
and chemical properties.

• It is a fast and efficient way to

analyze a large number of cells.
• Flow cytometry can be used to
diagnose various cell cycle
disorders.
Conclusion

Malfunctions in the cell cycle can

lead to various disorders and
diseases such as cancer,
Alzheimer's, and Huntington's
disease. Understanding the cell
cycle is crucial for early detection
and treatment of these diseases.