CHOLESTASIS

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• Cholestasis is: stagnation of bile due to
impairment of bile flow along its outflow tract.
accumulation of bile components in the
blood.
• Bile componenets are bilirubin and bile acids.
BILIRUBINOSTASIS: Retention of bilirubin.
CHOLATESTASIAS:Retention of bile acids

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 Types of cholestasis

• CYTOPLASMIC CHOLESTASIS: Presence of bile in

form of fine yellow pigment throughout the
cytoplasm of hepatocytes
• CANALICULAR CHOLESTASIS: Presence of bile
thrombi in bile canaliculi.
• DUCTULAR CHOLESTASIS: Stagnation of bile in
periportal bile ductules (ducts of Hering) which are
increased in number and are dilated.

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CYTOPLASMIC
CHOLESTASIS: Presence of
yellow pigment
throughout the
cytoplasm.

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- CANALICULAR
CHOLESTASIS: There are
bile thrombi in bile
canaliculi.

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- DUCTULAR CHOLESTASIS:
Periportal bile ductules
are hyperplastic, dilated
and contain bile stained
concrements.

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