Chronic inflammation

1. Chronic inflammation with acute onset:

In case of bacteria infection ,if bacteria survived inflammation
progress to chronic stage.
e.g bacillary dysentry (infection of colon)
bone infection
2. Chronic inflammation of isidious onset:
Caused by inflammatory agent and leads to chronic tissue
injury.
a.Particulate material:
Carbon dust….in lung……mass of macrophages.
Silica…….silicic acid by lysosomes.
b.Microbial infections:
In case of Leishmaniasis and bacillus……tissue injury and
necrosis.
c.Hypersensitivity reaction:
Chronic inflammation of an organ (gastritis) induce
hypersensitivity in the surrounding tissue………
destruction.
Appearance of chronic inflammation

1.Fluide exudate.
2.Active suppression
3.Infiltration by leucocytes.
4.Necrosis.
5.Formation of granuloma.
Inflammatory Endarteritis
The arteries in inflammed area showed proliferation of intima.

Inflammatory
Endophlebitis
The arteries in inflammed area
showed proliferation of intima.
 Types of cells in inflammatory
lesions
1. In blood:
a.Neutrophils b.Eosinophils
c.Lymphocytes d.Plasma cells
2. In body system:
a.Kupffer cells (liver)
b.Reticular cells (lymph nodes)
c.Histiocytes (connective tissue)
d.Alveolar macrophages (lung)
e.Osteoclasts ( bone).
f. Microglial cells (central nervous system).
Neutrophil
Polymorph
 Effect of Chronic inflammation
1.Fluide exudate.

2.Granuloma:
Act as a barrier to bacteria and toxins.