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Body Fluid Crystalloid (prefer) - small → goes into cell

• Male (60%) > female (50%) Colloid (↑ Cl → SE: acidosis) - max 1 - 1.5 L can be given, then crystalloid
• Most concentrated in skeletal muscle Colloid - bigger → stay in circulation; Ex: Dextran, Gelofusine (gelatin based)
• TBW = 0.6 x BW
• ICF = 0.4 x BW • Isotonic - NaCl 0.9%, Ringer’s lactate
• ECF = 0.2 x BW • Hypertonic - NaCl 1.8%, when diuretic → low Na but adequate body vol → so give small
• 3/4 → Extravascular interstitial fluid vol but high [Na]
• 1/4 → Intravascular plasma • Hypotonic - NaCl 0.18% or 0.45%, when diuretic → high Na & under vol → so give more
water than Na
Fluid regulation
• Renal sympathetic nerves Surgical pts prone to disruption
Fluid Requirement : 40ml/kg/DAY
• Renin-angiotensin-aldosterone system • Nil orally
Electrolytes require :
• Renin secreted when • Anaesthesia
- Na+: 1-2mmol/kg/day
• ↓ BP • Trauma
- K+: 0.5~1.0mmol/kg/day
• ↓ Na delivery to kidney • Sepsis
• ↑ sympathetic tone
Avoid fluid overload, esp in malnutrition, heart failure,
• Ag II → ↑ vascular tone
renal insufficiency
• ↑ catecolamine release
• ↓ renal blood flow
Normal maintenance requirements
• ↑ Na reabsorption
• Use BW formula
• Stimulate aldosterone release
On going losses
• Aldosterone
• Measure all losses in I/O chart
• Release stimutlated by
• Estimate 3rd space losses
• Angiotensin II
Deficits
• ↑K
• Estimate using vital signs & HCT
• ACTH
• Effect - Na and water
After therapy started observe
absorption in distal tubular • Vital signs
segments • Urine output (0.5mls/Kg/hr)
• Atrial natriuretic peptide (ANP)
• Central venous pressure

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Crsytalloid
• Hartmanns, D5%, NS 0.9%, Ringer’s lactate
• Advantage - cheap, easily available, no allergic rxn, isotonic
• Disadvantage - diffuse easily into Interstitial space

Colloid
• Dextran, gelafundin, starch, albumin
• Advantage – stays in intravascular space better
• Disadvantage – expensive, allergic rxn, affects cross-matching

Blood products
• Whole blood, packed cells, FFP
• Advantage – exact blood constituents, O2 carrying capacity 2
• Disadvantage – transfusion rxn, expensive to produce

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