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COLORECTAL CANCER
COLORECTAL CANCER
COLORECTAL CANCER
DEFINITION
is a disease in which cells in Colorectal cancer starts in
the colon or rectum grow out the colon or the rectum.
of control. Sometimes it is These cancers can also be
called colon cancer, for short.
called colon cancer or rectal
The colon is the large
cancer, depending on where
intestine or large bowel. The
they start. Colon cancer and
rectum is the passageway
that connects the colon to the rectal cancer are often
anus (Center for Disease grouped together because
Control and Prevention, they have many features in
2023). common.
Facts:
• Malignancy of colon/rectum
• If the disease is detected and
treated at an early stage, the 5
year survival rate is 90%.
• Only 34% of colorectal cancers
are found at an early stage.
• Colon polyps and early cancer
can have no symptoms.
Therefore, regular screening is
important.
PATHOPHYSIOLOGY
• Arise from preexisting benign
adenomatous colon polyps
• Transformation is slow = 1 cm polyp
take 7 years to progress to invasive
carcinoma
• (Adenomastically round and polypoid)
• Lesions penetrate the colon wall and
extend into surrounding tissue
• Lungs and liver metastasize
• Complications: perforation,
abscess formation, peritonitis,
sepsis, and shock.
RISK FACTORS
• Age > 40, increasing age
• Family history of colon CA or polyps
• Previous colon CA
• Personal hx of ulcerative colitis, Crohn’s disease for more than 10
years
• Onset is 63-67 years old
• Whites than African Americans
• Incidence higher in industrialized western world
• High fat diet, high intake of protein(beef), low fiber diet
• Excess alcohol intake
• Genital CA or breast CA
CLINICAL MANIFESTATIONS
• Change in bowel habits, constipation, diarrhea, and bowel
incontinence
• Hematochezia
• Melena
• Unexplained anemia
• Unusual stomach or gas pain
• Unexplained weight loss
• Fatigue
• Vomiting
SCREENING TEST FOR COLORECTAL CANCER