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histology #06

histology #06

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Published by hamza jassar

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Published by: hamza jassar on Aug 02, 2008
Copyright:Attribution Non-commercial

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06/16/2009

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UNIVERSITY
Of
J01IDAN
FacultyOF
Medicine
Lectureno:6
DATE:
15-7-2008
DONE
BY:
Bayan
AI-Khdoor
'------l
DR.:
F
ara
j
Al-
Bustami
 
By The Name Of Allah
 
Page 18 
Ossification =bone formationHow the bone is formed by (replacement) of preexisting connective tissue NOT by conversionThis connective tissue could be :*primitive mesenchymal connective tissue occurs by process calledintramembranous ossification *cartilage ( removal of cartilage by process called Endochondral ossification ) In these 2 process the essential process is the same ,and the very essential process is the presence of osteoblast(bone forming cell)Any connective tissue is rich in mesenchyme which rich with mesenchymalcell or from the cells that derived from it such as osteoprogenitor cellMinimal bones in our body are develop by intramembranous ossificationexamples (clavicle& most of the mandible &bone of the skull) , the majoritydeveloped by endochondral ossification examples ( bone of the extremities"bone of the lower limp "& vertebral column & base of the skull & face )Very important noteOsteoplast doesn’t form calcified bone directly, first it forms uncalcified bonematrix (osteoid)which rich with collagen type I& proteoglycanIf you are a nerd and remember that we find the osteoblast on the surface of existing bone tissue & on calcified cartilage during endochondral ossificationIf we want to remove the cartilage that be able by calcification the matrix of cartilage no more diffusion & arrival of nutrientsThen the cartilage will suicide
♫♫
 
 
 Page 17 Page 18 Primary center ossification appears in the embryo at the end of 8 week ( theend of the second month of intrauterine life )These changes appears in the middle of hyaline cartilaginous model (the futureshaft) By the way:Calcified matrix of cartilage is basophilic ( blue )*After calcification of cartilage the lacunae open ( large spaces ) and betweenit there are (divisions )which are the remnants of the calcified cartilage*in the middle of cartilage there are cavities & dead cell that make it moreweak soooooooo we need compensatory mechanism periostealcollar 
The cartilage are covered by perichondrium& in its innerlayer has chondrogenic cell which differentiate into osteoprogenitor cell ((NOW the perichondrium become known as periosteum)) then the osteoprogenator cell differentiate into osteoblast All these steps occur outside the cartilageThen form bone ( periosteal collar ) by intramembranous ossification
All newly formed bone isspongy bone whether it formby intramembranous orendochondral ossification thenit may converted into compactbone

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