Generic Name: Amoxicillin Brand Name: Amoxil, Polymox Classification: Non-narcotic analgesic, Antipyretic,Antibiotic

Uses 1. Ear, nose, and throat infections due to Streptococcus species. 2. GU Infections due to Escherichia coli, Proteus miribalis, Enterococcus facecalis. 3. Skin infections due to Streptococcus, S. pneumonia, Staphylococcus, or H. haemophilus 4. Acute uncomplicated gonococcal infections due to Neisseria gonorrhoeae. 5. In combination with omeprazole or lansoprazole to treat duodenal ulcers by eradicating Helicobacter pylori. Actions: This drug is a semi-synthetic broad spectrum penicillin closely related to Ampicillin. It binds to Penicillin-binding proteins in the cytoplasmic membranes of bacteria, thus inhibiting cell-wall synthesis. It also inhibits cell growth and cell division. It is better absorbed than Ampicillin. Contraindications: 1. Hypersensitivity 2. Use of the 875mg tablet in clients with a GFR less than 30mL/minute. Special Concerns: 1. Safe use during pregnancy has not been established. 2. Drug may decrease effectiveness of oral contraceptives. Side-Effects: 1. Hypersensitivity 2. Nausea 3. Vomiting 4. Gastritis 5. Stomatitis

Dosage: Per Orem: usual dose of 500mg q8h or 500mg q12h. For gonococcal infections: 3 grams single dose. Nursing Considerations: 1. Note for any hypersensitivity reaction 2. Instruct clients that therapeutic regimen must be completed even if symptoms subside. 3. Childs dose should not exceed maximum adult dose. 4. Clients with GFR of 10-30 mL/min should receive 250-500mg q12h. 5. Monitor CBC, renal and liver function tests. 6. May be taken with food. 7. Antibiotic resistance may occur if used without practitioner consultation as duration of therapy may not be completed. Report: bleeding, sore throat, rash, diarrhea, worsening of symptoms, lack of response.

Generice Name: Mefenamic Acid Brand Name:Ponstan, Ponstel Classifications:central nervous system agent; analgesic; nsaid; antipyretic Pregnancy Category:C Availability 250 mg tablets Actions Anthranilic acid derivative. Like ibuprofen inhibits prostaglandin synthesis and affects platelet function. No evidence that it is superior to aspirin. Therapeutic effects Analgesic, antiinflammatory, and antipyretic actions similar to those of ibuprofen. Uses Short-term relief of mild to moderate pain including primary dysmenorrhea. Contraindications Hypersensitivity to drug;GI inflammation,or ulceration.Safety in children <14 y, during pregnancy (category C), or lactation is not established. Cautious use History of kidney or liver disease;blood dyscrasias;asthma;diabetes mellitus;hypersensitivity to aspirin. Long term use increases risk of serious adverse events. Route & Dosage Mild to Moderate Pain adult: PO Loading Dose 500 mg PO Maintenance Dose 250 mg q6h prn Administration Oral Give with meals, food, or milk to minimize GI adverse effects.Do not use drug for a period exceeding 1 wk (manufacturers warning). Adverse effects CNS:Drowsiness, insomnia, dizziness, nervousness,

confusion, headache. GI:Severe diarrhea, ulceration, and bleeding; nausea, vomiting, abdominal cramps, flatus, constipation, hepatic toxicity. Hematologic:Prolonged prothrombin time, severe autoimmune hemolytic anemia (long-term use), leukopenia, eosinophilia, agranulocytosis, thrombocytopenic purpura, megaloblastic anemia, pancytopenia, bone marrow hypoplasia. Urogenital:Nephrotoxicity, dysuria, albuminuria, hematuria, elevation of BUN. Skin:Urticaria, rash, facial edema. SpecSenses:Eye irritation, loss of color vision (reversible), blurred vision, ear pain. BodyWhole:Perspiration. CV:Palpitation. Respiratory:Dyspnea; acute exacerbation of asthma; bronchoconstriction (in patients sensitive to aspirin). Nursing implications Assessment & Drug Effects Assess patients who develop severe diarrhea and vomiting for dehydration and electrolyte imbalance. Lab tests: With long-term therapy (not recommended) obtain periodic complete blood counts, Hct and Hgb, and kidney function tests. Patient & Family Education Discontinue drug promptly if diarrhea, dark stools, hematemesis, ecchymoses, epistaxis, or rash occur and do not use again. Contact physician. Notify physician if persistent GI discomfort, sore throat, fever, or malaise occur. Do not drive or engage in potentially hazardous activities until response to drug is known. It may cause dizziness and drowsiness. Monitor blood glucose for loss of glycemic control if diabetic. Do not breast feed while taking this drug without consulting physician.