Brand Name: Ponstan

Generic Name: Mefenamic Acid

Indications: Mild to moderate pain in rheumatic disease and other musculo-skeletal
disorders, reduce high body temperature, lessen the pain of menstrual
problems.
Drug Classification: Anti-inflammatory, analgesic
Mechanism of Action: It works by blocking the action of a substance in the body called
cyclo-oxygenase. Cyclo-oxygenase is an enzyme that is involved in the
production of various chemicals in the body, some of which are known as
prostaglandins. Prostaglandins are produced in response to injury or certain
diseases and cause pain, swelling and inflammation. As mefenamic acid
stops the production of prostaglandins, it is effective at relieving pain and
inflammation.
Mefenamic acid may also works by preventing the action of prostaglandins
after they have already been formed.
Dosage: initially 500 mg, followed by 250 mg q 6 hrs prn.
Special Precautions: Patients with any allergic condition (including asthma).
Pregnancy Risk Category: B
Adverse Reactions:
GI: Nausea, GIT disturbances may eventually result in ulceration,
CNS: drowsiness, dizziness
Contraindications: Patients with inflammations in the intestines, peptic ulcers, or
impaired liver or kidney function, or who are pregnant.
Forms: Capsules – 250mg, 500 mg; tablets; soluble tablets; children’s suspension for
dilution;
Nursing Responsibilities:
 Administer with meals, food, or milk to minimize GI adverse effects.
 Diabetic patients may show increased need for insulin.
 Children under 12 years of age should be prescribed mefenamic acid
liquid, rather than tablets or capsules, as this allows a more accurate
dose to be given.
 Advise client to notify physician if persistent GI discomfort, sore
throat, fever, or malaise occur.