Irreversible cell injury Irreversible cell injury If the damage continues, the injury will be irreversible, in which the cell would not be able to improve themselves and cell death occurs. There are two types of cell death, namely necrosis and apoptosis. Both of these deaths differ in morphology, mechanism, and role in physiological and disease. Irreversible cell injury The most frequent manifestation is characterized by necrosis koagulatif cell swelling, cytoplasmic protein denaturation, and breakdown of cell organelles The mechanism of irreversible cell injury Two events that marked the irreversible state: Inability altering mitochondrial dysfunction The presence of large disturbance function