ABSTRACT

Sugesti, Nanda. 2014. Chromosome Analysis As The Cause Of Intellectual

Disability On Student Of Special School (Slb) C Alpa Kumara Wardhana II
Surabaya. Final Assignment, Faculty of Medicine, Wijaya Kusuma
Surabaya University. Supervisor: drg. Retno Dwi M., M.kes.

Introduction: Mental retardation or which currently called the intellectual

disability is a intellectual function disorder which is showed functional deficits in
adaptive behavior, social and communication skills in everyday life. In the most
cases, individuals with intellectual disability has an IQ below 70. Many cause
factors of intellectual disability which is influence each other and continuesly
such as, malnutrition or drugs consumed by pregnant mother, neuro toxic
substances, premature birth, cerebral ischemia, pre- or post-natal infection, and
genetic disorders.
Method of the Study: This research is a descriptive observational
research. The sample is student of Special School (SLB) C Alpa Kumara
Wardhana II Surabaya with suspected of intellectual disability. The number of
sample is 1 person.
Result of the Study: Phenotypes are found in patients such as the oval
face, prominent forehead, hypertelorism (distance between the eyes), a high and
narrowed palate, pes planus o(flat feet), on the genitalia found signs of secondary
sex and there is a hernia in the testes. The result of karyotiping is 46, XY.
Conclusion: The result of chromosome analysis shows that there is no
abnormality of chromosome structure and number. This study needs to be
continued with molecular test to determine abnormalities that occurat the level of
DNA and chromosome abnormalities in submicroscopic level.
Keywords: intelectual disability, chromosome analysis, phenotype