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  • Deriving Henderson Hasselbach

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    The document derives the Henderson-Hasselbach equation, which relates the pH of a weak acid solution to the acid dissociation constant (Ka) and the concentration of the acid and its conjugate base. It starts with the chemical equilibrium of a weak acid dissociating into a hydrogen ion and conjugate base ion. Taking the negative log of both sides of the Ka expression and substituting pH for -log[H+] and pKa for -log Ka yields the final Henderson-Hasselbach equation relating pH to pKa and the log of the concentration ratio of the acid and its conjugate base.

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    How to derive Henderson Hasselbach equation

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    The document derives the Henderson-Hasselbach equation, which relates the pH of a weak acid solution to the acid dissociation constant (Ka) and the concentration of the acid and its conjugate base. It starts with the chemical equilibrium of a weak acid dissociating into a hydrogen ion and conjugate base ion. Taking the negative log of both sides of the Ka expression and substituting pH for -log[H+] and pKa for -log Ka yields the final Henderson-Hasselbach equation relating pH to pKa and the log of the concentration ratio of the acid and its conjugate base.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    22 views1 page

    Deriving Henderson Hasselbach

    Uploaded by

    Anonymous Sfcml4GvZ
    The document derives the Henderson-Hasselbach equation, which relates the pH of a weak acid solution to the acid dissociation constant (Ka) and the concentration of the acid and its conjugate base. It starts with the chemical equilibrium of a weak acid dissociating into a hydrogen ion and conjugate base ion. Taking the negative log of both sides of the Ka expression and substituting pH for -log[H+] and pKa for -log Ka yields the final Henderson-Hasselbach equation relating pH to pKa and the log of the concentration ratio of the acid and its conjugate base.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Deriving the Henderson-Hasselbach Equation

    HA

    H+ + A

    H +

    Ka=
    *Rearrange Ka to find [H+]
    H +

    *Take log of both sides of equation


    H +

    log
    *substitute pH for log[H+] and pKa for log Ka
    pH= pKalog

    [ HA ]
    [A]

    *Henderson Hasselbach equation


    A

    pH= pKa+ log

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