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ยาต้านพิษ 2556
ยาต้านพิษ 2556
Antivenoms
Atropine
Pralidoxime, 2-PAM
N-acetylcysteine
Sodium bicarbonate
Polyethylene glycol electrolyte solution
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2556
5,000
270 6 10400
0 2201 1084
0 2201 1085 1
766/36-39 .
10120
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Fax. 0-2688-4842
Email : scanart03@yahoo.com
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()
(.)
Snake antivenoms
Atropine
Pralidoxime (2-PAM)
N-acetylcysteine (NAC)
Sodium bicarbonate
11
14
solution (PEG-ELS)
18
23
24
25
Snake antivenoms
(Indications)
1.
2.
(Contraindications)
(Adverse reactions)
(early reaction)
(late reaction)
1-2
(Drug interaction)
3-5 vials
3-5 vials 3 vials
5 vials
skin test
30
(Formulation)
(vial)
10
Atropine
(Indications)
1.
muscarinic cholinergic
2. (bradycardia)
3. (asystole)
4. (bronchospasm)
(Contraindications)
1.
2. (narrow-angle glaucoma)
(Adverse reactions)
(Drug interaction)
(Formulation)
0.6
Pralidoxime, 2-PAM
(Indications)
(Contraindications)
1. oximes
2.
(absolute contraindication)
(Adverse reactions)
(Drug interaction)
N-acetylcysteine (NAC)
(Indications)
1.
(150
/ )
treatment line Rumack-Matthew Nomogram
2.
(
8 )
150 //
6 /24 ()
48
100 //
4 /24 72
3.
chlorinated hydrocarbon
(Contraindications)
NAC
(Adverse reactions)
1. NAC
2. NAC
anaphylactoid
angioedema
(Drug interaction)
NAC
NAC
(Dosage and administration)
1. : 140 /
70 / 4 17
2. :
2.1 ( 40 )
2.4
NAC 150 /
5% Dextrose in water 1000
24
NAC,
10 / 36
48
(Formulation)
(powder granules)
100, 200
600
(effervescent tablet)
600
(intravenous
infusion) 100 /
10
Sodium Bicarbonate
(Indications)
1. Cardiotoxicity fast sodium channel blockade
(widening QRS complex) tricyclic antidepressants ( amitriptyline, doxepin, imipramine, nortriptyline )
type Ia, Ic antiarrhythmic drugs ( quinidine, f lecainide,
encainide, propafenone, moricizine)
2. Urine alkalinization salicylate, phenobarbital, chlorpropamide overdose severe rhabdomyolysis
3. Metabolic acidosis
4. Hyperkalemia
(Contraindications)
1. Severe alkalemia serum pH> 7.55
2. Severe hypernatremia
3. Severe hypokalemia
4. Severe pulmonary edema, congestive heart failure,
anuria without plan for dialysis
11
(Adverse reactions)
1. Alkalemia hypokalemia, hypocalcemia
2. Hypernatremia volume overload
heart failure, pulmonary edema
3. Inf lflammation necrosis
(Drug interaction)
salicylate, phenobarbital,
chlorpropamide
(Dosage and administration)
1. Cardiotoxicity sodium channel blockade 1-2
/ IV bolus 1-2
(QRS complex widening, wide QRS complex
tachycardia, hypotension) 5
serum pH 7.45-7.55
(continuous IV infusion)
12
(Formulation)
: sodamint 300
: 7.5% sodium
bicarbonate injection (0.89 / 10
50 )
13
14
3.
(Adverse reactions)
diverticulitis (upper gastrointestinal bleeding)
(Drug interaction)
(Dosage and administrations)
9 - 6 500
6 - 12 1,000
1,500-2,000
15
(Formulation)
PEG-ELS
PEG-ELS PEG-ELS, 4000
PEG 4000
sodium and potassium salt
16
17
www.nhso.go.th
1. website (.)
www.nhso.go.th
2.
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5. Login
5.1 US/PW .
US/PW
5.2 US/PW
. activate US/PW
stock online GIS
6.
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6.2 Diagnosis
6.3
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6.5
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E-mail
084-3878045
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