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    Janet AnaIs López Arciniega
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    This document presents the key findings of a study that determined the 3.3 angstrom resolution crystal structure of an RNA polymerase II elongation complex from yeast. The structure provides insights into the transcription bubble, closure of the RNA polymerase clamp, downstream DNA mobility, and other aspects of RNA synthesis and exit from the active site. It represents the first near-atomic resolution view of an elongating eukaryotic transcription complex.

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    This document presents the key findings of a study that determined the 3.3 angstrom resolution crystal structure of an RNA polymerase II elongation complex from yeast. The structure provides insights into the transcription bubble, closure of the RNA polymerase clamp, downstream DNA mobility, and other aspects of RNA synthesis and exit from the active site. It represents the first near-atomic resolution view of an elongating eukaryotic transcription complex.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    5 views17 pages

    Structural Basis of Transcription

    Uploaded by

    Janet AnaIs López Arciniega
    This document presents the key findings of a study that determined the 3.3 angstrom resolution crystal structure of an RNA polymerase II elongation complex from yeast. The structure provides insights into the transcription bubble, closure of the RNA polymerase clamp, downstream DNA mobility, and other aspects of RNA synthesis and exit from the active site. It represents the first near-atomic resolution view of an elongating eukaryotic transcription complex.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    of 17

    Structural Basis of Transcription: An

    RNA Polymerase II Elongation Complex


    at 3.3 Å Resolution

    Averell L. Gnatt,Patrick Cramer, Jianhua Fu,


    David A. Bushnell, Roger D. Kornberg

    2008
    Introducción
    Structure of a pol II
    transcribing complex

    ✴ DNA template(Blue)

    ✴Nontemplate strands
    (Green)

    ✴RNA i(red)
    Structure of a pol II transcribing complex
    Structure of a pol II transcribing complex
    Closure of the clamp
    Closure of
    the clamp
    Downstream DNA mobility
    Transcription bubble
    Transcription bubble
    Transcription bubble
    DNA-RNA hybrid
    DNA-RNA hybrid
    RNA synthesis
    RNA exit
    Conclusions and prospects
    1) Introducción Humberto
    2)Structure of a pol II transcribing
    complex Itzel
    3)Closure of the clamp Pilar
    4)Downstream DNA mobility Ismael
    5)Transcription bubble Cristy
    6)DNA-RNA hybrid Vero
    7)RNA synthesis Janet
    8)RNA exit Liset
    9)Conclusions and prospects Juan

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